[This abstract first appeared in: Dementia: the Latest Evidence Newsletter RWHT Volume 1 Issue 7 February 2011].
This US prospective cohort study looked into whether statins (simvastatin, lovastatin, pravastatin and atorvastatin) reduce the risk of Alzheimer’s Disease (AD), and investigated the influence of age and presence of the apolipoprotein E (APOE) e4 allele.
Over 3,000 participants were tested for probable AD. Overall, use of statins reduced the risk of probable AD after adjusting the data for demographic characteristics and vascular risk factors. When taking age into account, the effects of statins were significant only in patients aged 65-80 years and not in patients older than 80 years. Statin use appeared to reduced risk of AD in those with an e4 allele but not in patients without.
Rosenberg, PB. (2011). Exposure to statins in early old age but not in late old age may be associated with a lower risk of developing Alzheimer’s disease. Evidence Based Mental Health, January 26th 2011, Vol.14(1), p.14.
Li, G. Shofer, JB. Rhew, IC. [et al] (2010). Age-varying association between statin use and incident Alzheimer’s disease. Journal of the American Geriatric Society, July 2010, Vol.58(7), pp.1311-7.