Auditory Event-Related Potentials (Future Directions in the Diagnosis and Assessment of Dementia?)


This review examines event-related potentials (ERPs) as under-utilised clinical and research instruments which could play a role in the diagnosis and evaluation of neurological / psychiatric disorders, including dementia. ERPs are noninvasive and reflect cortical neuronal activity directly.

Previous studies using the P300 (Parietocentral Positivity), P3a (Frontocentrally Maximal Positive ERP), and MMN (Mismatch Negativity) components of the ERP to study dementia are reviewed. It appears that the P300 brain potential is particularly sensitive to Alzheimer’s Disease in its early stages, and that simple stimulus discrimination tasks are most useful clinically. The evidence suggests that the P300 ERP could be used in the diagnosis of dementia and in the assessment of early Alzheimer’s Disease.

Full Text Link


Vecchio, F. [and] Määttä, S. (2011).  The use of auditory event-related potentials in Alzheimer’s disease diagnosis. International Journal of Alzheimer’s Disease, May 15th 2011. [Epub ahead of print]. (Click here to view the PubMed abstract).

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
This entry was posted in Diagnosis, For Researchers (mostly), International, Systematic Reviews and tagged , , , , , , , , , , , , . Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.