Health Technology Assessment Study into the Use of Antidepressants for Depression in Dementia (HTA-SADD)

[A version of this item appears in: Dementia: the Latest Evidence Newsletter (RWHT), Volume 2 Issue 1, August 2011].

Summary

Research into the efficacy and safety of two of the most commonly prescribed drugs, sertraline and mirtazapine, has found that these treatments have little advantage compared with placebo (i.e. no treatment) for the treatment of depression in Alzheimer’s Disease. The use of these antidepressants needs to be reconsidered, given the absence of benefit compared to placebo and the increased risk of adverse events for people prescribed these medicines while suffering from depression and Alzheimer’s Disease.

Full Text Link. (Access requires an Athens password or journal subscription).

Reference

Banerjee, S. Hellier, J. [and] Dewey, M. [et al] (2011). Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial. Lancet, July 30th 2011, Vol.378(9789), pp.403-11. (Click here to view the PubMed abstract).

Full Text Link. (Access requires an Athens password or journal subscription).

Reference

Brodaty, H. (2011). Antidepressant treatment in Alzheimer’s disease. Lancet, July 30th 2011, Vol. 378(9789), pp. 375-6. (Click here to view the PubMed citation).

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
This entry was posted in Acute Hospitals, Community Care, Depression, For Doctors (mostly), For Researchers (mostly), In the News, Management of Condition, Pharmacological Treatments, Quick Insights, Universal Interest and tagged , , , , , , , . Bookmark the permalink.

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