A study by US researchers, and published in the Neurology journal, has linked hormone replacement therapy (HRT) in women to both an increased and a decreased risk of Alzheimer’s Disease, depending on the type of hormones used and the timing of the therapy.
The study examined whether the association of hormone therapy (HT) with Alzheimer’s Disease (AD) varies with timing or type of hormone replacement therapy use. The Cache County Study followed 1,768 women, between 1995 and 2006, who had provided a detailed history on age at menopause and use of HT. During this period, 176 women developed Alzheimer’s Disease.
Statistical analysis showed that women who used any type of HT within 5 years of menopause had a 30% lower risk of AD, especially if use was for 10 years or more. In contrast, risk of AD was not reduced among women who initiated HT 5 or more years after menopause.
The researchers conclude that the association between HT use and risk of AD may depend on the timing of use in relation to menopause. HT is apparently more beneficial if taken during a critical window near menopause, whereas HT (especially opposed compounds) initiated in later life may be associated with increased risk of women developing Alzheimer’s Disease. Further studies are required.
Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access).
Shao, H. Breitner, JC. Whitmer, RA. [et al] (2012). Hormone therapy and Alzheimer disease dementia: New findings from the Cache County Study. Neurology, October 30th 2012, Vol.79(18), pp.1846-1852. (Click here to view the PubMed abstract).
Full Text Link (b) (Note: This article requires a suitable Athens password, a journal subscription or payment for access).
Henderson, VW. Rocca, WA. (2012). Estrogens and Alzheimer disease risk: Is there a window of opportunity? Neurology, October 30th 2012, Vol.79(18), pp.1840-1. (Click here to view the PubMed record).
See also an earlier article:
Dye, RV. Miller, KJ. [and] Singer, EJ. [et al] (2012). Hormone replacement therapy and risk for neurodegenerative diseases. International Journal of Alzheimer’s Disease, Epub April 4th 2012. (Click here to view the PubMed abstract).