Psoriasis Drug May Halt Alzheimer’s Disease?: “Behind the Headlines” Appraisal (NHS Choices / Nature Medicine)


The NHS Choices “Behind the Headlines” service produces regular critical appraisals of recent research about elderly care and dementia-related topics which have appeared in the news. Here is one more of these master-class evaluations.

Animal Research on Psoriasis Drug to Slow or Reverse Progression of Alzheimer’s Disease?

Immune system proteins IL-12 and IL-23 play a potential role in Alzheimer’s Disease, according to mouse models. Research published in Nature Medicine, based on animal research using mice, suggests that blocking these proteins with antibodies against a component called p40 could reduce the formation of amyloid beta plaque and might apparently reverse some of the associated behavioural problems in a mouse model of Alzheimer’s Disease.

NICE already recommends treatment of severe psoriasis that has not responded to standard therapy with a drug containing an antibody against p40 (ustekinumab), so there could be shorter delays before human trials. More research is required.

Full Text Link (a)


Psoriasis drug could hold key to dementia treatment. London: NHS Choices; Behind the Headlines, November 26th 2012.

This relates to:

Full Text Link (b) (Note: This article requires a suitable Athens password, a journal subscription or payment for access).


Vom Berg, J. Prokop, S. [and] Miller, KR. [et al] (2012). Inhibition of IL-12/IL-23 signaling reduces Alzheimer’s disease-like pathology and cognitive decline. Nature Medicine. Epub ahead of print. November 25th 2012.

[A brief reference to this item features in Dementia and Elderly Care: the Latest Evidence Newsletter (RWNHST), Volume 3 Issue 5, January 2013].

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
This entry was posted in Animal Studies, BBC News, For Doctors (mostly), For Researchers (mostly), In the News, International, Models of Dementia Care, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, Universal Interest and tagged , , , , , , , , , , , , , , , , , , , , . Bookmark the permalink.

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