This systematic review investigates the efficacy and safety of combination therapy with N-methyl-D-aspartic acid antagonists (memantine) and cholinesterase inhibitors (ChEIs) for treatment of dementia, compared to monotherapy with either memantine or a ChEI. Combination therapy appears to offer statistically significant improvements in moderate to severe Alzheimer’s Disease, but it remains unclear whether clinically significant outcomes result from combination therapy. More research is required.
Muayqil, T. Camicioli, R. (2013). Systematic review and meta-analysis of combination therapy with cholinesterase inhibitors and memantine in Alzheimer’s disease and other dementias. Dementia and Geriatric Cognitive Disorders Extra, January 2013, Vol.2(1), pp.546-72. (Click here to view the PubMed abstract).
[A version of this item features in Dementia: the Latest Evidence, Volume 3 Issue 6, February 2013].