Combination Therapy with Cholinesterase Inhibitors and Memantine (Dementia and Geriatric Cognitive Disorders Extra)

Summary

This systematic review investigates the efficacy and safety of combination therapy with N-methyl-D-aspartic acid antagonists (memantine) and cholinesterase inhibitors (ChEIs) for treatment of dementia, compared to monotherapy with either memantine or a ChEI. Combination therapy appears to offer statistically significant improvements in moderate to severe Alzheimer’s Disease, but it remains unclear whether clinically significant outcomes result from combination therapy. More research is required.

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Reference

Muayqil, T. Camicioli, R. (2013). Systematic review and meta-analysis of combination therapy with cholinesterase inhibitors and memantine in Alzheimer’s disease and other dementias. Dementia and Geriatric Cognitive Disorders Extra, January 2013, Vol.2(1), pp.546-72. (Click here to view the PubMed abstract).

[A version of this item features in Dementia: the Latest Evidence, Volume 3 Issue 6, February 2013].

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About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
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