This article discusses recent progress, and problems remaining, in the clinical diagnosis of Dementia with Lewy Bodies (DLB). The sensitivity of accurate clinical diagnosis of DLB is said to be low. It seems likely that it may be possible to increase diagnostic accuracy using a combination of cellular pathologies including:
- β-amyloid deposition.
- Dopamine denervation.
Novel techniques may soon advance understanding of the pathogenesis of DLB and help clarify clinical and pathologic diagnostic criteria. The pathogenesis of DLB is still understood imperfectly.
Huang, Y. Halliday, G. (2013). Can we clinically diagnose dementia with Lewy bodies yet? Translational Neurodegeneration, February 11th 2013, Vol.2(4), pp.1-9. (Click here to view the PubMed abstract).
[A brief reference to this item features in Dementia and Elderly Care: the Latest Evidence Newsletter (RWNHST), Volume 3 Issue 7, May 2013].
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Gore, RL. Vardy, ER. O’Brien, JT. (2015). Delirium and dementia with Lewy bodies: distinct diagnoses or part of the same spectrum? Journal of Neurology, Neurosurgery and Psychiatry. January 2015; 86(1): 50-59.