Issues in the Clinical Diagnosis of Dementia with Lewy Bodies (Translational Neurodegeneration)


This article discusses recent progress, and problems remaining, in the clinical diagnosis of Dementia with Lewy Bodies (DLB). The sensitivity of accurate clinical diagnosis of DLB is said to be low. It seems likely that it may be possible to increase diagnostic accuracy using a combination of cellular pathologies including:

  1. α-synuclein.
  2. β-amyloid deposition.
  3. Dopamine denervation.

Novel techniques may soon advance understanding of the pathogenesis of DLB and help clarify clinical and pathologic diagnostic criteria. The pathogenesis of DLB is still understood imperfectly.

Full Text Link


Huang, Y. Halliday, G. (2013). Can we clinically diagnose dementia with Lewy bodies yet? Translational Neurodegeneration, February 11th 2013, Vol.2(4), pp.1-9. (Click here to view the PubMed  abstract).

[A brief reference to this item features in Dementia and Elderly Care: the Latest Evidence Newsletter (RWNHST), Volume 3 Issue 7, May 2013].

Possibly also of interest:

Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access).


Gore, RL. Vardy, ER. O’Brien, JT. (2015). Delirium and dementia with Lewy bodies: distinct diagnoses or part of the same spectrum? Journal of Neurology, Neurosurgery and Psychiatry. January 2015; 86(1): 50-59.

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
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