Rapid eye movement (REM) sleep behaviour disorder is caused by the loss of the normal muscle paralysis during REM sleep. This tendency to “act out dreams” can appear three decades or more before a formal diagnosis of dementia with Lewy bodies in males, which makes it a potential indicator of DLB which could facilitate early diagnosis of the condition.
Researchers at the Mayo Clinic have found that patients are five times more likely to have – or to be developing – dementia with Lewy bodies if they experience rapid eye movement (REM) sleep behavior disorder than if they have one of the indicative risk factors used currently to make a DLB diagnosis, such as parkinsonism, fluctuating cognition or hallucinations.
These findings were presented at the annual meeting of the American Academy of Neurology in San Diego. The researchers have also found that the link between dementia with Lewy bodies and this sleep disorder is not as strong in women.
Read more and view the video: Acting Out Dreams Linked to Development of Dementia. Mayo Clinic News.
Readers may also be interested in articles on related developments from the same research teams:
Full Text Link (a) (Note: This article requires a suitable Athens password, a journal subscription or payment for access).
Boeve, BF. Silber, MH. [and] Ferman, TJ. [et al] (2013). Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder. Sleep Medicine, March 6th 2013. , [Epub ahead of print]. (Click here to view the PubMed abstract).
Full Text Link (b) (Note: This article requires a suitable Athens password, a journal subscription or payment for access).
Kantarci, K. Ferman, TJ. [and] Boeve, BF. [et al] (2012). Focal atrophy on MRI and neuropathologic classification of dementia with Lewy bodies. Neurology, August 7th 2012, Vol.79(6), pp.553-60. (Click here to view the PubMed abstract).
Full Text Link (c) (Note: This article is available free).
Dugger, BN. Boeve, BF. [and] Murray, ME. [et al] (2012). Rapid eye movement sleep behavior disorder and subtypes in autopsy-confirmed dementia with Lewy bodies. Movement Disorders: Official Journal of the Movement Disorder Society, January 2012, Vol.27(1), pp.72-8. (Click here to view the PubMed abstract).
[A brief reference to this item features in Dementia and Elderly Care: the Latest Evidence Newsletter (RWNHST), Volume 3 Issue 7, May 2013].