Centrally Acting ACE Inhibitors Reduce Rate of Cognitive Decline in Dementia? (BMJ Open)


It has been found that taking angiotensin-converting enzyme (ACE) inhibitors, a class of drugs which help to reduce blood pressure by relaxing the walls of blood vessels, may help to slow mental decline in people diagnosed with dementia.

The short and small study in question discovered that patients taking centrally acting ACE inhibitors had slightly slower rates of mental decline than those who were not taking them over a six-month period. Further, the mental ability of patients newly prescribed ACE inhibitors appeared to improve slightly.

This NHS Choices “Behind the Headlines” critical appraisal helps to place this research into perspective.

Note: ACE inhibitors may accelerate certain forms of dementia, and not everyone might benefit.

Full Text Link (a)


Blood pressure drug may help treat dementia. London: NHS Choices; Behind the Headlines, July 26th 2013.

This relates to:

Full Text Link (b)


Gao, Y. O’Caoimh, R. [and] Healy, L. [et al] (2013). Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia. BMJ Open, July 25th 2013, Vol.3(7), e002881. (Click here to view the PubMed abstract).

[A brief reference to this item features in Dementia and Elderly Care: the Latest Evidence Newsletter (RWNHST), Volume 3 Issue 9, August 2013].

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
This entry was posted in For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), Hypertension, In the News, International, Management of Condition, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, Universal Interest and tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , . Bookmark the permalink.

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