Copper Disrupts Brain Amyloid-β Production and Clearance? (NHS Choices / PNAS)


This NHS Choices “Behind the Headlines” critical appraisal of recent research in the news is about a laboratory study carried out on mice and human brain cells, investigating whether copper may reduce the capacity of the brain to get rid of a protein linked to Alzheimer’s Disease called amyloid beta. Increased copper levels in blood plasma or the blood vessels in the brain appears to be associated with development of Alzheimer’s Disease, presumably by copper influencing and partially preventing the clearance of amyloid beta.

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Dietary copper intake may be linked to Alzheimer’s. London: NHS Choices; Behind the Headlines, August 20th 2013.

This relates to:

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Singh, I. Sagare, AP. [and] Coma, M. [et al] (2013). Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance. Proceedings of the National Academy of Sciences of the United States of America, August 19th 2013. [Epub ahead of print]. (Click here to view the PubMed abstract).

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
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