Giant Steps: Re-Tracing the Development of a Promising Research Approach


Following the announcement earlier this week of a probable (if still early-stage) historic breakthrough in finding a potential approach to preventing neurodegeneration across Alzheimer’s, Parkinson’s and Huntington’s Diseases, readers may be interested in viewing the publication history of research team’s lead researcher Prof Giovanna Mallucci. Some of these articles are available freely. The full-text of the other articles may need a suitable Athens password, a journal subscription or payment for access.

The Bibliographic Citations

Firstly, the free articles:

In the interests of tracing the history of ideas and developments, the following articles are presented in reverse chronological order (most recent first):


Moreno, JA. Halliday, M. [and] Molloy, C. [et al] (2013). Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. Science Translational Medicine. October 9th 2013; 5(206): 206ra138.

Halliday, M. [and] Mallucci, GR (2013). Targeting the unfolded protein response in neurodegeneration: a new approach to therapy. Neuropharmacology. September 10th 2013. [Epub ahead of print].

Halliez, S. Chesnais, N. [and] Mallucci, GR. [et al] (2013). Targeted knock-down of cellular prion protein expression in myelinating Schwann cells does not alter mouse prion pathogenesis. Journal of General Virology. June 2013; 94(Pt 6): 1435-40.


Radford, HE. Verity, NC. [and] Martin, MG. [et al] (2012). Removal notice to “acute depletion of the prion protein may abrogate Aβ oligomer toxicity” [Toxicology 290 (2011) 124]. Toxicology. December 16th 2012; 302(2-3): 320.

Moreno, JA. Radford, H. [and] Peretti, D. [et al] (2012). Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature. May 6th 2012; 485(7399): 507-11. Full Text Link.


Verity, NC. [and] Mallucci, GR (2011). Rescuing neurons in prion disease. Biochemical Journal. January 1st 2011; 433(1): 19-29.


Moreno, JA. [and] Mallucci, GR. (2010). Dysfunction and recovery of synapses in prion disease: implications for neurodegeneration. Biochemical Society Transactions. April 2010; 38(2): 482-7. Review.

Radford, HE. [and] Mallucci GR. (2010). The role of GPI-anchored PrP C in mediating the neurotoxic effect of scrapie prions in neurons. Current Issues in Molecular Biology. 2010; 12(2): 119-27. Review. Full Text Link.


Mallucci, GR. (2009). Can mutations of prion protein shed light on its normal function? Journal of Neurology Neurosurgery and Psychiatry. December 2009; 80(12): 1303. Full Text Link.

White, MD. [and] Mallucci, GR. (2009). RNAi for the treatment of prion disease: a window for intervention in neurodegeneration? CNS and Neurological Disorders Drug Targets. November 2009; 8(5): 342-52. Review.

Mallucci, GR. (2009). Prion neurodegeneration: starts and stops at the synapse. Prion. – October – December 2009; 3(4): 195-201. Review. Full Text Link.

White, MD. [and] Mallucci, GR. (2009). Therapy for prion diseases: Insights from the use of RNA interference. Prion. July – September 2009; 3(3): 121-8. Full Text Link.


White, MD. Farmer, M. [and] Mirabile, I. [et al] (2008). Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease. Proceedings of the National Academy of Sciences of the United States of America. July 22nd 2008; 105(29): 10238-43. Full Text Link.

2007 and Earlier:

Further  citations are available via PubMed.

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
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