Extracellular Tau Proteins Can Spread Tau Pathology (NHS Choices / Journal of Biological Chemistry)


A recent NHS Choices critical appraisal has covered research into the role and development of Tau protein and speculating whether traumatic brain injury might provide opportunities for Tau proteins to spread. This research found that short exposure to Tau proteins outside of neural cells can lead to the infection of healthy cells, and initiate the aggregation of endogenous Tau. The resulting Tau aggregates can subsequently be released back into the extracellular medium, where they are in turn capable of infecting other cells and causing a neurodegenerative chain reaction.

This research has been misinterpreted (or over-interpreted) by the media as implying that footballers and boxers could be more likely to develop Alzheimer’s Disease.

Full Text Link


Footballers ‘no more likely’ to get Alzheimer’s disease. London: NHS Choices; Behind the Headlines, November 28th 2013.

This relates to:

Full Text Link


Michel, CH. Kumar, S. [and] Pinotsi, D. [et al] (2013). Extracellular monomeric Tau is sufficient to initiate the spread of Tau pathology. The Journal of Biological Chemistry, November 14th 2013, [Epub ahead of print]. (Click here to view the PubMed abstract).

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
This entry was posted in For Doctors (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, UK, Universal Interest and tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , . Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.