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Monthly Archives: January 2014
DDT (Pesticide): Potential Link with Alzheimer’s Disease (BBC News / JAMA Neurology)
Summary Exposure to the pesticide DDT, which was used commonly after WW2, may increase the risk of developing Alzheimer’s Disease, according to research published in JAMA Neurology. Patients with Alzheimer’s Disease, statistically, had four times more residual DDT lingering in … Continue reading
Posted in BBC News, For Doctors (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Statistics, Universal Interest
Tagged Amyloid Precursor Protein (APP), Apolipoprotein E, Apolipoprotein E (APOE) e4 Allele, Apolipoprotein E (APOE) Gene, BBC Health News, Behind the Headlines, Critical Appraisals, DDE, DDT (Pesticide), Department of Environmental and Occupational Medicine: Rutgers Robert Wood Johnson Medical School, Department of Neurology and Alzheimer's Disease: Emory University School of Medicine, Department of Pathology: Emory University School of Medicine, Department of Psychiatry: University of Texas Southwestern Medical Center, Dichlorodiphenyldichloroethylene (DDE), Dichlorodiphenyltrichloroethane (DDT), Elevated Serum Pesticide Levels, Emory University, Environmental and Lifestyle Factors, Environmental and Occupational Health Sciences Institute: Rutgers University, Epidemiology, Epidemiology and Statistics, JAMA Neurology, Pesticides, Pesticides and Dementia, Risk Factors, Risk Factors for Alzheimer's Diseease, Rutgers University, Serum Pesticide Levels
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CQC Monitoring of the Mental Health Act (BBC News / CQC)
Summary The number of people in England detained under the Mental Health Act has risen by 12% during the past five years, according to the Care Quality Commission (CQC). The Mental Health Act was used over 50,000 times to detain patients … Continue reading
Posted in Acute Hospitals, BBC News, Community Care, CQC: Care Quality Commission, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), In the News, Mental Health, National, NHS, Quick Insights, Standards, Statistics, UK, Universal Interest
Tagged Access and Advocacy, Access to Mental Health Services, Adult Social Care Provision (CQC), Advocacy, Advocacy and Advice Services, Assessment of Inpatient Mental Health Services, Breakthrough, Care Quality Commission (CQC), Commissioning Older People’s Mental Health Services, Community Care, Community Mental Health Services, Community Treatment Orders (CTOs), Community-Based Interventions, Community-Based Mental Health and Social Care Services, Community-Based Services, Complaints, Complaints Handling, Complex Transitions, Coventry and Warwickshire Partnership NHS Trust, CQC MHA Complaints System, De Facto Detention, Detained Patients, Devon Partnership NHS Trust, Dudley and Walsall Mental Health Partnership NHS Trust, Engagement, Experts by Experience, Independent Mental Capacity Advocacy (IMCA) Service, Independent Mental Health Advocate (IMHA) Services, Inpatient Mental Health Services, Mental Health Act (MHA), Mental Health Act 1983, Mental Health Act and Community Treatment Orders, Mental Health Crisis, Mental Health Service User Reference Panel (SURP), MHA Monitoring, Optional Protocol to the Convention against Torture (OPCAT), Patient Complaints, Patient Engagement, Physical Restraint, Physical Restraint in Hospital Settings, Physical Restraint in Mental Healthcare, Police Custody, Positive Practice in Mental Health Awards, Quality and User Involvement, Regulation and Inspection of Mental Health Services, Restraint in Health and Adult Social Care, Restriction, Restrictive Practices, Sectioning under the Mental Health Act, Service User Experience in Adult Mental Health Services, Service User Involvement, Solent NHS Trust, South West London and St George’s Mental Health NHS Trust, United Nations Optional Protocol to the Convention Against Torture (OPCAT), User Complaints, User Involvement
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Eldest Age Group’s Ambulance Trips to Accident and Emergency Rising Disproportionately (BBC News)
Summary The number of over-90s taken to A&E by ambulance in England has risen by 81% over the past three years, rising from approximately 165,910 in 2009-10 to 300,370 during 2012-13. Overall 999 trips to A&Es, for all age-groups, rose by 11% … Continue reading
Posted in Acute Hospitals, BBC News, Commissioning, Community Care, For Carers (mostly), For Nurses and Therapists (mostly), For Social Workers (mostly), In the News, Integrated Care, National, NHS, Quick Insights, Standards, Statistics, UK, Universal Interest
Tagged Accident and Emergency Departments, Accident and Emergency Statistics, Age and Ageing, Ageing, Ageing and Society, Ageing Population, Avoidable Admissions, Avoidable Rehospitalisations, BBC Health News, Care Integration, Care of Frail Older People With Complex Needs, Coordinated Care, Emergency Admission Rates in UK, Emergency Admissions, Emergency Ambulance Services, Emergency and Urgent Care Services, Emergency Care, Emergency Departments, Frail Elders, Frail Older People With Complex Needs, Health and Social Care Information Centre (HSCIC), Hospital Episode Statistics: Accident and Emergency Statistics, Hospital Episodes Statistics (HES), HSCIC: Health and Social Care Information Centre, Inappropriate Accident and Emergency Department Attendances, Labour Party, Oldest Old, Oldest Old in the United Kingdom, Preventable Hospital Admissions, Primary Care, Primary Care Alternatives to Emergency Hospital Admissions, Primary Care Service Interventions, Reducing Inappropriate Accident and Emergency Department Attendances, Reducing Unnecessary Admissions, Reducing Unscheduled Admissions, Unnecessary Hospital Admissions, Unplanned Hospital Admissions, Unscheduled Admissions, Urgent and Emergency Care, Urgent and Emergency Services, Wellbeing and an Ageing Population
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Bapineuzumab Trials Results in Mild-to-Moderate Alzheimer’s Disease (New England Journal of Medicine)
Summary Bapineuzumab is an anti-amyloid-beta monoclonal antibody, which had shown promise for the treatment of Alzheimer’s Disease. Two double-blind, randomised, placebo-controlled, phase 3 trials have been conducted, involving 2204 patients with mild-to-moderate Alzheimer’s disease. One trial involved 1121 carriers of … Continue reading
Posted in For Doctors (mostly), For Researchers (mostly), International, Pharmacological Treatments
Tagged Alzheimer's Disease Assessment Scale (ADAS-Cog11), Amyloid, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Apolipoprotein E, Apolipoprotein E (APOE) e4 Allele, Apolipoprotein E (APOE) Gene, Bapineuzumab 301, Bapineuzumab 302, Bapineuzumab for Mild-to-Moderate Alzheimer's Disease, Bapineuzumab Trials, Beta-Amyloid, Beta-Amyloid Plaques, Brigham and Women's Hospital: Boston, Butler Hospital, Cerebrospinal Fluid Phosphorylated Tau (Phospho-Tau) Concentrations, Cleo Roberts Center for Clinical Research, Clinical Trials Number NCT00574132, Clinical Trials Number NCT00575055, Columbia University, Disability Assessment for Dementia-DAD, EudraCT Number 2009-012748-17, Institute of Neurology: University College London, Janssen Alzheimer Immunotherapy and Pfizer, Janssen Alzheimer Immunotherapy Research and Development, New England Journal of Medicine, New York University Langone Medical Center, Pfizer, Pittsburgh Compound B (PIB-PET), Sahlgrenska University Hospital, Sun Health Research Institute, Sweden, University College London, University of California, University of Göteborg, University of Pittsburgh, University of Rochester School of Medicine and Dentistry, Veterans Affairs Medical Center
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Solanezumab Trials Results for Mild-to-Moderate Alzheimer’s Disease (New England Journal of Medicine)
Summary Solanezumab is a monoclonal antibody which binds soluble amyloid preferentially and had shown some promise of promoting better clearance of amyloid-beta from the brain in pre-clinical studies. Two placebo controlled trials (EXPEDITION 1 and EXPEDITION 2) of 1012 and … Continue reading
Posted in For Doctors (mostly), For Researchers (mostly), International, Pharmacological Treatments
Tagged Alzheimer's Disease and Memory Disorders Center: Baylor College of Medicine (Houston), Alzheimer's Disease Assessment Scale (ADAS-Cog11), Alzheimer's Disease Cooperative Study Steering Committee, Alzheimer's Disease Cooperative Study-Activities of Daily Living scale (ADCS-ADL), Alzheimer's Disease Cooperative Study: University of California at San Diego, Amyloid, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Baylor College of Medicine, Beta-Amyloid, Beta-Amyloid Plaques, Center for Human Experimental Therapeutics: University of Rochester Medical Center, Centre Hospitalier Universitaire Toulouse, Clinical Trials Number: NCT00904683, Clinical Trials Number: NCT00905372, Department of Neuropathology: University of Tokyo, Eli Lilly, Gerontopole: Unité Mixte de Recherche, Gliosis, Indiana Alzheimer Disease Center: Indiana University, Indiana University, β-amyloid, Neurofibrillary Tangles, Neuronal Loss, New England Journal of Medicine, Solanezumab for Mild-to-Moderate Alzheimer’s Disease, Solanezumab Study Group, Solanezumab Trials, Solanezumab: Humanised Monoclonal Antibody, University of California at San Diego, University of Pennsylvania, University of Rochester Medical Center
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