The authors performed a systematic review and meta-analysis of randomised controlled studies comparing the outcomes of antipsychotics discontinuation (versus their continuation) in people with dementia. Changes to the severity of behavioural and psychological symptoms of dementia (BPSD) was the primary outcome.
The evidence indicates that antipsychotic discontinuation did not result in a statistically significant difference in BPSD severity change or mortality. A significantly higher proportion of subjects with BPSD did, however, have worse symptoms compared to the continuation group. The authors recommend that further studies are needed to explore the effects of antipsychotic discontinuation on BPSD.
Pan, YJ. Wu, CS. Gau, SS. [et al]. Antipsychotic discontinuation in patients with dementia: a systematic review and meta-analysis of published randomized controlled studies. Dementia and Geriatric Cognitive Disorders. October 19th 2013; 37(3-4): 125-140. [Epub ahead of print].