Discontinuation of Antipsychotics in Patients with Dementia (Dementia and Geriatric Cognitive Disorders)


The authors performed a systematic review and meta-analysis of randomised controlled studies comparing the outcomes of antipsychotics discontinuation (versus their continuation) in people with dementia. Changes to the severity of behavioural and psychological symptoms of dementia (BPSD) was the primary outcome.

The evidence indicates that antipsychotic discontinuation did not result in a statistically significant difference in BPSD severity change or mortality. A significantly higher proportion of subjects with BPSD did, however, have worse symptoms compared to the continuation group. The authors recommend that further studies are needed to explore the effects of antipsychotic discontinuation on BPSD.

Full Text Link


Pan, YJ. Wu, CS. Gau, SS. [et al]. Antipsychotic discontinuation in patients with dementia: a systematic review and meta-analysis of published randomized controlled studies. Dementia and Geriatric Cognitive Disorders. October 19th 2013; 37(3-4): 125-140. [Epub ahead of print].

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
This entry was posted in Acute Hospitals, Antipsychotics, Community Care, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Management of Condition, Mental Health, Models of Dementia Care, Pharmacological Treatments, Quick Insights, Systematic Reviews and tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , . Bookmark the permalink.

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