Reversing Certain Aspects of the Ageing Process in Mice (BBC News / NHS Choices / Cell)


Researchers in the USA would appear to have identified a new mechanism of ageing, based on the functional decline in the mitochondria inside muscle cells. The also claim to have discovered how to reverse this specific process.

Levels of a chemical called NAD+ drop naturally in cells as the body ages. It has been found, based on experiments with mice, that increasing NAD+ levels – by giving the mice a chemical which is converted into NAD+ – appears to improve mitochondrial functioning and thereby reverse the ageing process in question.

Expert reviewers of this research remind readers that ageing is a multi-factorial process, so the effect observed here (while potentially important) would be unlikely to be a “magic bullet” with the potential to cure-all the aspects of ageing, even at the cellular level.

BBC News. Youth-drug can reverse ageing in animal studies.


Gallagher, J. (2013). Youth-drug can ‘reverse’ ageing in animal studies. London: BBC Health News, December 20th 2013.

This subject is explored further by the following NHS Choices Behind the Headlines critical appraisal:

Full Text Link


Another cell study spun as ‘age-reversing miracle’. London: NHS Choices Behind the Headlines, December 20th 2013.

This relates to:

Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access).


Gomes, AP. Price, NL. [and] Ling, AJ. [et al] (2013). Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell, December 19th 2013, Vol.155(7), pp.1624-38. (Click here to view the PubMed abstract).

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
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