Blood-based protein biomarkers to predict the onset and progression of Alzheimer’s Disease (AD) would assist in timely diagnosis and would also be beneficial for clinical trials in helping with the selection of subjects for preventative trials. This systematic review considers 163 candidate biomarkers. Four candidate biomarkers appear to be AD-related: α-1-antitrypsin, α-2-macroglobulin, apolipoprotein E, and complement C3. A large-scale replication study has been performed on 94 of the 163 candidate biomarkers..
Kiddle, SJ. Sattlecker, M. Proitsi, P. [et al] (2014). Candidate blood proteome markers of Alzheimer’s Disease onset and progression: a systematic review and replication study. Journal of Alzheimer’s Disease: JAD. 2014; 38(3): 515-31. (Click here to view the PubMed abstract).