Given earlier research showing familial aggregation in Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) separately, the authors of this systematic review decided to investigate the extent of any familial co-occurrence of AD and PD. Only a modest degree of familial coaggregation of AD and PD became apparent, implying that any co-occurrence of dementia and parkinsonism is caused primarily by factors other than shared familial risk.
Feldman, AL. Johansson, AL. Lambert, PC. [et al] (2014). Familial coaggregation of Alzheimer’s disease and Parkinson’s disease: systematic review and meta-analysis. Neuroepidemiology. February 2014; 42(2): 69-80. (Click here to view the PubMed abstract).