Exposure of Aged Mice to Young Blood Plasma Improves Age-Related Cognitive Impairment? (BBC News / NHS Choices / Nature Medicine / Science)

Summary

Researchers at Stanford University believe they might have discovered a novel method of slowing, or even reversing, a range of ageing processes (mental and physical). Their work, based on mice so far, involved injecting the blood of young mice into older rodents. The injected mice performed better on memory tests.

It appears that exposure of an ageing animal to young blood can counteract and reverse certain pre-existing effects of brain ageing “at the molecular, structural, functional and cognitive level”. Researchers plan further studies to discover the active agent(s) at work. Early trials in people are also planned, to determine whether new treatments for dementia might be developed.

This is early research at present, and some caution may be necessary when assessing the potential significance of such disease-modifying treatments for humans.

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Reference

Briggs, H. (2014). New blood ‘recharges old brain’, mouse study suggests. London: BBC Health News, May 5th 2014.

This research is explored in more detail, and put into perspective, by an NHS Choices Behind the Headlines critical appraisal:

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Reference

Could young blood ‘slow’ ageing? London: NHS Choices Behind the Headlines, May 6th 2014.

This relates to:

Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access).

Reference

Villeda, SA. Plambeck, KE. [and] Middeldorp, J. [et al] (2014). Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine. May 4th 2014. [Epub ahead of print]. (Click here to view the PubMed abstract).

Also of interest:

Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access).

Reference

Katsimpardi, L. Litterman, NK. [and] Schein, PA. [et al] (2014). Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. May 5th 2014. [Epub ahead of print]. (Click here to view the PubMed abstract).

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
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