Summary
Cancer, heart disease, type-2 diabetes, infections and obesity have been linked to insufficient and / or disrupted sleep.
Reference
Gallagher, J. (2014). ‘Arrogance’ of ignoring need for sleep. London: BBC Health News, May 12th 2014.
Irregular sleep patterns have been linked to higher cancer risk in mice.
Reference
Gallagher, J. (2015). Poor sleeping patterns link to cancer. London: BBC Health News, July 21st 2015.
This relates to:
Reference
Van Dycke, KC. Rodenburg, W. [and] van Oostrom, CT. [et al] (2015). Chronically alternating light cycles increase breast cancer risk in mice. Current Biology: CB, July 20th 2015, Vol.25(14), pp.1932-7. (Click here to view the PubMed abstract).
A related appraisal:
Reference
Night shifts ‘linked to increased breast cancer risk’. London: NHS Choices Behind the Headlines, July 21st 2015.
Chronotherapy
There is said to be growing interest in the science of chronotherapy i.e. the better alignment of medical treatments to circadian rhythms:
Reference
Gallagher, J. (2014). Chronotherapy: the science of timing drugs to our Body Clock. London: BBC Health News, May 13th 2014.
More on Circadian Rhythms and the Potential for Chronotherapy
An animal study monitoring the levels of cell functioning in 12 tissues through the day discovered changes in activity just before dawn and dusk. This understanding might help with chronotherapy; potentially enabling better timing in the administration of medications to hit sweet-spots in the body clock.
Reference
Gallagher, J. (2014). Body clock: ‘Rush hour’ transformation discovered. London: BBC Health News, October 28th 2014.
This relates to:
Reference
Zhang, R. Lahens, NF. [and] Ballance, HI. [et al] (2014). A circadian gene expression atlas in mammals: implications for biology and medicine. Proceedings of the National Academy of Sciences of the United States of America. October 27th 2014. [Epub ahead of print].
See also:
Reference
Gallagher, J. Buchanan, R. [and] Gill, V. [et al] (2014). Body clock: what makes you tick? London: BBC Health News, May 2014.
Possibly also of interest:
Reference
Gallagher, J. (2014). Night work ‘throws body into chaos’. London: BBC Health News, January 21st 2014.
This relates to:
Reference
Archer, SN. Laing, EE. [and] Möller-Levet, CS. [et al] (2014). Mistimed sleep disrupts circadian regulation of the human transcriptome. Proceedings of the National Academy of Sciences of the United States of America. February 11th 2014, 111(6), pp.E682-91. (Click here to view the PubMed abstract).
Type 2 diabetes is more common among shift workers:
Reference
Gallagher, J. (2014). Shift workers ‘face type 2 diabetes risk’. London: BBC Health News, July 25th 2014.
The link between long working hours and type 2 diabetes tends to be more prevalent among individuals of low socioeconomic status:
Kivimäki, M. Virtanen, M. Kawachi, I. [et al] (2014). Long working hours, socioeconomic status, and the risk of incident type 2 diabetes: a meta-analysis of published and unpublished data from 222 120 individuals. Lancet, Diabetes and Endocrinology. January 2015; 3(1): 27-34. Full Text Link.
The Role of Sleep in Learning / Memory Formation
Researchers at New York University School of Medicine and Peking University Shenzhen Graduate School may have uncovered sleep’s role in the mechanisms of memory.
Reference
Gallagher, J. (2014). Sleep’s memory role discovered. London: BBC Health News, June 6th 2014.
This relates to:
Reference
Yang, G. Lai, CS. [and] Cichon, J. [et al] (2014). Sleep promotes branch-specific formation of dendritic spines after learning. Science, June 6th 2014, 344(6188), pp.1173-8. (Click here to view the PubMed abstract).
More circumstantial evidence indicating an association between poor sleep quality, impaired memory formation and possibly the risk of Alzheimer’s Disease is discussed elsewhere.
According to research at Northwestern University, Chicago, it may be possible to reduce levels of unconscious racist or sexist bias by manipulating how the brain learns during sleep.
Reference
Gallagher, J. (2015). Sleep training ‘may reduce racism and sexism’. London: BBC Health News, May 29th 015.
Possibly also of interest:
Reference
Sleep deprivation may affect memory. London: NHS Choices Behind the Headlines, July 23rd 2014.
Learning in early life (and just possibly in later life), too, appears to benefit from regular and lengthy naps:
Reference
Gallagher, J. (2015). Regular naps are ‘key to learning’. London: BBC Health News, January 13th 2015.
This relates to:
Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access).
Reference
Seehagen, S. Konrad, C. Herbert, JS. [and] Schneider, S. (2015). Timely sleep facilitates declarative memory consolidation in infants. Proceedings of the National Academy of Sciences. January 12th 2015. [Epub ahead of print].
See also:
Reference
Napping ‘key’ to babies’ memory and learning. London: NHS Choices Behind the Headlines, January 13h 2015.
Napping and Cardiovascular Disease (CVD)
Inconclusive evidence on the relationship between daytime napping and the probability of having a heart attack or stroke.
Reference
Afternoon naps may lower heart attack and stroke risk. London: NHS Digital Behind the Headlines, September 11th 2019.
This relates to:
Reference
Häusler, N. Haba-Rubio, J. [and] Heinzer, R. [et al] (2019). Association of napping with incident cardiovascular events in a prospective cohort study. Heart. September 9th 2019. [Epub ahead of print].
Editorial commentary:
Reference
Leng, Y. [and] Yaffe, K. (2019). To nap or not to nap: more questions than answers. Heart. September 9th 2019. [Epub ahead of print].
Official Statistics (HSCIC)
People working shifts (in England) tend to have higher rates of obesity and long-term health problems than the general population (i.e. those working normal hours), according to HSCIC Health Survey for England statistics on shift work:
Reference
Gallagher, J. (2014). Shift workers ‘sicker and fatter’. London: BBC Health News, December 15th 2014.
An appraisal, and some practical advice, from NHS Choices:
Reference
Shift workers more likely to report poor health. London: NHS Choices; Behind the Headlines, December 18th 2014.
Blue Light and Electronic Entertainment
Research at Harvard Medical School has shown that blue light, the wavelength commonly used by smartphones, tablets and LED lighting, is able to disrupt the body clock. Blue light in the evening / bed-time is able to reduce or prevent the production of the sleep hormone melatonin. It can take longer to get to sleep using an e-reader than a paper book, resulting in poorer quality sleep and more tiredness the following morning.
Reference
Gallagher, J. (2014). E-readers ‘damage sleep and health,’ doctors warn. London: BBC Health News, December 23rd 2014.
This relates to:
Reference
Chang, AM. Aeschbach, D. [and] Duffy, JF. [et al] (2014). Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness. Proceedings of the National Academy of Sciences (PNAS). December 22nd 2014. [Epub ahead of print].
More recently:
Reference
Gallagher, J. (2015). Phones need ‘bed mode’ to protect sleep. London: BBC Health News, November 15th 2015.
This relates to:
Reference
Gringras, P. Middleton, B. [and] Skene, DJ. (2015). Bigger, brighter, bluer-better? current light-emitting devices – adverse sleep properties and preventative strategies. Frontiers in Public Health. October 13th 2015, Vol.3, pp.233. (Click here to view the PubMed abstract).
Possibly of interest, the Royal Society for Public Health in 2018 launched the “Scroll Free September” campaign.
Sleep Deprivation / Sleep Cycles / Purpose of Sleep
Reference
Who, what, why: Is surviving on 20-minute naps bad for you?. London: BBC Health News / BBC NewsMagazine, May 13th 2015.
Reference
Ghosh, P. (2015). Why do we sleep? London: BBC Health News / BBC NewsMagazine, May 15th 2015.
Sporting Ability
The body clock has an impact of up to 26% on sporting ability:
Reference
Gallagher, J. (2015). Bedtime ‘has huge impact on sport’. London: BBC Health News, January 30th 2015.
This relates to:
Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access).
Reference
Facer-Childs, E. [and] Brandstaetter, R. (2015). The impact of circadian phenotype and time since awakening on diurnal performance in athletes. Current Biology. January 29th 2015. [Epub ahead of print].
Susceptibility to Common Colds?
Shorter sleep duration / sleep deprivation appears to be associated with increased susceptibility to the common cold:
Reference
Does lack of sleep make you susceptible to common cold?. London: NHS Choices Behind the Headlines, September 1st 2015.
This relates to:
Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access).
Reference
Prather, AA. Janicki-Deverts, D. [and] Hall, MH. [et al] (2015). Behaviorally assessed sleep and susceptibility to the common cold. Sleep, September 2015; 38(9): pp.1353-9. (Click here to view the PubMed abstract).
Coffee and the Body Clock
Caffeine delays the human circadian clock and modifies cellular timekeeping via an adenosine receptor-dependent mechanism. Drinking the equivalent of a double espresso three hours before sleep can “turn back” the body clock by about one hour. This may have implications for various sleep conditions.
Reference
A coffee in the evening turns the body clock back by around an hour. London: Medical Research Council (MRC), September 16th 2015.
See also:
Reference
Gallagher, J. (2015). Coffee has secret trick to stop sleep. London: BBC Health News, September 17th 2015.
Circannual Rhythm (Body Calendar)
On the annual clock, known as the circannual rhythm:
Reference
Gallagher, J. (2015). Body’s ‘chemical calendar’ discovered. London: BBC Health News, September 25th 2015.
Global Sleep Patterns
Global sleeping patterns are being investigated using data harvested by the Entrain app:
Reference
Gallagher, J. (2016). Global sleeping patterns revealed by app data. London: BBC Health News, May 7th 2016.
This relates to:
Reference
Walch, OJ. Cochran, A. [and] Forger, DB. (2016). A global quantification of “normal” sleep schedules using smartphone data. Science Advances. May 6th 2016, 2016; 2 : e1501705.
The Economic Costs of Sleep Deprivation
A report by Rand Europe estimates a loss equivalent to 1.86% of economic growth:
Reference
Hope, K. (2016). Sleep deprivation ‘costs UK £40bn a year’. London: BBC Health News / BBC Business News, November 30th 2016.
Adverse Effects in Heart Surgery Depend on Circadian Rhythm?
Open heart surgery may be safer in the afternoon, apparently because the heart is stronger / better able to withstand surgery in the afternoon than in the morning:
Reference
Gallagher, J. (2017). Heart surgery survival chances ‘better in the afternoon’. London: BBC Health News, October 27th 2017.
This relates to:
Reference
Montaigne, D. Marechal, X. [and] Modine, T. [et al] (2017). Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study. Lancet. October 26th 2017. [Epub ahead of print].
Possibly of also of interest:
Reference
Afternoon open heart surgery ‘leads to fewer complications’, study reports. London: NHS Choices; Behind the Headlines, October 27th 2017.
Heart Disease Risk Increased By Night-Time Eating?
Animal research on the impact of circadian rhythm upon the management of blood triglyceride levels:
Reference
Night-time eating linked to heart disease. London: NHS Choices; Behind the Headlines, November 8th 2017.
Speed of Wound Healing?
Wounds appear to heal more quickly after occurring during the day (17 days) rather than at night (28 days).
Reference
Gallagher, J. (2017). Daytime wounds ‘heal more quickly’. London: BBC Health News, November 9th 2017.
See also:
Reference
Daytime wounds may heal faster. London: NHS Choices; Behind the Headlines, November 9th 2017.
Lunar Influences on Sleep?
Possible influence of the moon?
Reference
Wright, K. (2018). Can a full Moon really affect your sleep? London: BBC Health News, May 1st 2018.
Association Between Chronotype, Morbidity And Mortality
Late-nighters (“night-owls”) may be more likely to suffer poor mental and physical health (and die sooner).
Reference
Therrien, A (2018). Should we sleep and wake early to boost our health? London: BBC Health News, May 13th 2018.
This relates to:
Reference
Knutson, KL. [and] von Schantz, M. (2018). Associations between chronotype, morbidity and mortality in the UK Biobank cohort. Chronobiology International: the Journal of Biological and Medical Rhythm Research. April 11th 2018: 1-9. [Epub ahead of print].
Rules of Thumb for Better Sleep
Reference
Therrien, A (2018). Sleep tips: six ways to boost the chances of a good night’s rest. London: BBC Health News, May 16th 2018.
Disruptions to Body Clock Associated With Mood Disorders?
Reference
Gallagher, J. (2018). Body clock linked to mood disorders. London: BBC Health News, May 16th 2018.
This relates to:
Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access).
Reference
Lyall, LM. Wyse, CA. [and] Graham, N. [et al] (2018). Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91,105 participants from the UK Biobank. Lancet Psychiatry. May 15th 2018. [Epub ahead of print].
See also, the NHS Choices Behind the Headlines coverage of this research:
Reference
Body clock disruptions linked to mood disorders. London: NHS Choices, Behind the Headlines, May 16th 2018.
Insights From ChronoNutrition
The discipline of chrono-nutrition tends to confirm an old adage:
“Breakfast like a king, lunch like a prince and dine like a pauper”.
Reference
Therrien, A (2018). Are we eating at the wrong time for our body clocks? London: BBC Health News, May 20th 2018.
BBC Reality Check
Myth-buster (festive and light-hearted) on short-term sleep disruption:
Reference
Schraer, R. (2018). Reality Check: Do you sleep worse at Christmas? London: BBC Health News / BBC Reality Check Team, December 25th 2018.
