Alzheimer’s Disease Genetics Research: Two New Susceptibility Genes (PloS One)

Summary

An international collaboration of geneticists investigating susceptibility genes for Alzheimer’s Disease has identified two additional genes (chromosome 8 TP53INP1 and chromosome 14 IGHV1-67). These two genetic susceptibility loci appear to be involved in energy metabolism, protein degradation and the immune system.

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Reference

Escott-Price, V. Bellenguez, C. [and] Wang, LS. [et al] (2014). Gene-wide analysis detects two new susceptibility genes for Alzheimer’s disease. PloS One, June 12th 2014, Vol.9(6), pp.e94661. (Click here to view the PubMed abstract).

Genetics of Schizophrenia

Possibly also of interest, researchers have found 80 previously unknown genes which appear to increase the risk of developing schizophrenia:

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Reference

Mundasad, S. (2014). ‘Eighty new genes linked to schizophrenia’. London: BBC Health News, July 22nd 2014.

The following NHS Choices Behind the Headlines critical appraisal offers more information about this research:

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Reference

Study offers insight into genetics of schizophrenia. London: NHS Choices Behind the Headlines, July 22nd 2014.

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About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
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