Alzheimer’s Disease Genetics Research: Two New Susceptibility Genes (PloS One)

Summary

An international collaboration of geneticists investigating susceptibility genes for Alzheimer’s Disease has identified two additional genes (chromosome 8 TP53INP1 and chromosome 14 IGHV1-67). These two genetic susceptibility loci appear to be involved in energy metabolism, protein degradation and the immune system.

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Reference

Escott-Price, V. Bellenguez, C. [and] Wang, LS. [et al] (2014). Gene-wide analysis detects two new susceptibility genes for Alzheimer’s disease. PloS One, June 12^th 2014, Vol.9(6), pp.e94661. (Click here to view the PubMed abstract).

Genetics of Schizophrenia

Possibly also of interest, researchers have found 80 previously unknown genes which appear to increase the risk of developing schizophrenia:

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Reference

Mundasad, S. (2014). ‘Eighty new genes linked to schizophrenia’. London: BBC Health News, July 22^nd 2014.

The following NHS Choices Behind the Headlines critical appraisal offers more information about this research:

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Reference

Study offers insight into genetics of schizophrenia. London: NHS Choices Behind the Headlines, July 22^nd 2014.