Pharmacological Treatment for Agitation in Alzheimer’s Disease? (JAMA)

Summary

Combination dextromethorphan-quinidine shows early signs of being a safe and effective treatment option for Alzheimer’s Disease-related agitation.

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Reference

Cummings, JL. Lyketsos, CG. [and] Peskind, ER. [et al] (2015). Effect of dextromethorphan-quinidine on agitation in patients with Alzheimer Disease dementia: a randomized clinical trial. JAMA: Journal of the American Medical Association. September 22^nd – 29^th 2015, Vol.314(12), pp.1242-54. (Click here to view the PubMed abstract).

There is a related JAMA editorial, but this is not freely available; a suitable Athens password, a journal subscription or payment is required for access:

Ballard, C. Sharp, S. [and] Corbett, A. (2015). Dextromethorphan and quinidine for treating agitation in patients with Alzheimer Disease dementia. JAMA: Journal of the American Medical Association. September 22^nd – 29^th 2015, Vol.314(12), pp.1233-5.