Dementia Drug Effective in Helping Avoid Transitions into Care Homes (MRC / BBC News / Lancet Neurology)


Analysis of data from the DOMINO-AD Trial indicates that the drug Donepezil may be effective in avoiding care home admissions in more advanced cases of Alzheimer’s Disease. Discontinuation of donepezil appears to be associated with an increased risk of nursing home admissions in community-living patients with moderate-to-severe Alzheimer’s Disease during the first 12 months following drug cessation.

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Withdrawing dementia drug doubles risk of nursing home placement. London: Medical Research Council (MRC), October 26th 2015.

See also:

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Triggle, N. (2015). Dementia drug ‘keeps patients out of nursing homes’. London: BBC Health News, October 27th 2015.

This relates to:

Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access).


Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer’s Disease (DOMINO-AD) trial: secondary and post-hoc analyses. The Lancet Neurology. [Epub ahead of print].

Background information on the DOMINO-AD trial:

Full Text Link


Jones, R. Sheehan, B. [and] Phillips, P. [et al] (2009). DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer’s disease – a multicentre RCT. Trials, July 24th 2009, 10, 57. (Click here to view the PubMed abstract).

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
This entry was posted in Alzheimer's Society, BBC News, Commissioning, Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), In the News, Integrated Care, Management of Condition, Mental Health, Models of Dementia Care, National, Patient Care Pathway, Patient Information, Person-Centred Care, Pharmacological Treatments, Practical Advice, Quick Insights, Scotland, Statistics, UK, Universal Interest and tagged , , , , , , , , , , . Bookmark the permalink.

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