Genetic Mutation Which Delays Alzheimer’s Disease? (NHS Choices / Molecular Psychiatry)

Summary

A study of 71 persons from an extended family (comprising around 5,000 people) in northern Colombia, who carry a mutation in a gene called PSEN1 (the so-called the Paisa mutation, which causes a rare, severe form of early-onset Alzheimer’s disease), has identified a genetic variation called APOE*E2 which appears to delay the start of Alzheimer’s Disease – at least in people with the mutated PSEN1 gene – by around 12 years.

Note: It is uncertain whether these findings might apply to people beyond this family group carrying the mutated PSEN1 gene causing this specific unusual form of Alzheimer’s Disease.

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Reference

Scientists find ‘gene that delays Alzheimer’s’. London: NHS Choices Behind the Headlines, December 2nd 2015.

This relates to:

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Reference

Vélez, JI. Lopera, F. [and] Sepulveda-Falla, D. [et al] (2015). APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer’s disease. Molecular Psychiatry. December 1st 2015. [Epub ahead of print]. (Click here to view the PubMed abstract).

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About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
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