A study of 71 persons from an extended family (comprising around 5,000 people) in northern Colombia, who carry a mutation in a gene called PSEN1 (the so-called the Paisa mutation, which causes a rare, severe form of early-onset Alzheimer’s disease), has identified a genetic variation called APOE*E2 which appears to delay the start of Alzheimer’s Disease – at least in people with the mutated PSEN1 gene – by around 12 years.
Note: It is uncertain whether these findings might apply to people beyond this family group carrying the mutated PSEN1 gene causing this specific unusual form of Alzheimer’s Disease.
Scientists find ‘gene that delays Alzheimer’s’. London: NHS Choices Behind the Headlines, December 2nd 2015.
This relates to:
Vélez, JI. Lopera, F. [and] Sepulveda-Falla, D. [et al] (2015). APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer’s disease. Molecular Psychiatry. December 1st 2015. [Epub ahead of print]. (Click here to view the PubMed abstract).