Targeting Brain Inflammation May Help Protect Against Alzheimer’s Disease? (BBC News / MRC / NHS Choices / Brain)

Summary

Animal research at the University of Southampton, funded by the Medical Research Council (MRC) and Alzheimer’s Research UK indicates that blocking a receptor (CSF1R), which is responsible for regulating the production of new immune cells (microglia) in the brain, might help protect against progression of Alzheimer’s Disease in mice.

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Reference

Blocking brain inflammation ‘halts Alzheimer’s disease’. London: BBC Health News, January 8^th 2016.

See also:

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Study shows beneficial effects of blocking brain inflammation in an experimental model of Alzheimer’s. London: Medical Research Council (MRC), January 8^th 2016.

Further detail:

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Targeting inflammation ‘could help treat Alzheimer’s disease’. London: NHS Choices Behind the Headlines, January 8^th 2015.

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Reference

Olmos-Alonso, A. Schetters, ST. [and] Sri, S. [et al] (2016). Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology. Brain: a Journal of Neurology. January 8^th 2016. [Epub ahead of print]. (Click here to view the PubMed abstract).