Repurposing of Existing Drugs to Prevent Dementia? (BBC News / Science Advances /Alzheimer’s Research UK)


A number of drugs, already approved as safe for the treatment of other conditions, and which could help protect against Alzheimer’s Disease, are said to have been detected and short-listed for further investigation.

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Alzheimer’s preventative drug hope. London: BBC Health News, February 13th 2016.

Possibly of interest, about an approved anticancer drug thought to target selectively the first step in the molecular cascade resulting in Alzheimer’s Disease:

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Habchi, J. Arosio, P. [and] Perni, M. [et al] (2016). An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease. Science Advances. February 12th 2016, 2016; 2 : e1501244.

A pinch of context (critical appraisal):

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Alzheimer’s disease ‘wonder drug’ claims are premature. London: NHS Choices Behind the Headlines, February 15th 2016.

A recent USA trial involving humans:

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Cummings, JL. Zhong, K. [and] Kinney, JW. [et al] (2016). Double-blind, placebo-controlled, proof-of-concept trial of bexarotene X in moderate Alzheimer’s disease. Alzheimer’s Research and Therapy. January 29th 2016, Vol.8(1), 4. (Click here to view the PubMed abstract).

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
This entry was posted in Alzheimer's Society, Alzheimer’s Research UK, Animal Studies, BBC News, Charitable Bodies, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, UK, Universal Interest and tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , . Bookmark the permalink.

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