Monthly Archives: August 2016

Re-Evaluating the Effectiveness of Joint Reminiscence Groups: the REMCARE Trial (PLoS One)

Posted on August 31, 2016 by Dementia and Elderly Care News

Summary The REMCARE Trial investigated the relative benefits and effectiveness of joint reminiscence groups, i.e. reminiscence therapy interventions involving people with dementia and their family carers together. The researchers did not find evidence supporting the clinical effectiveness or cost-effectiveness of … Continue reading →

Posted in Commissioning, Community Care, For Carers (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), Management of Condition, Mental Health, Models of Dementia Care, Non-Pharmacological Treatments, Person-Centred Care, Quick Insights, UK, Universal Interest, Wales | Tagged Activities of Daily Living, Aneurin Bevan Health Board: Ystrad Mynach Hospital, Autobiographical Memory, Autobiographical Memory Interview (AMI), Bangor, Bangor University, Bradford, Bradford Dementia Group: University of Bradford, Carer Patient Dyad Relationship Quality, Carer Stress, Centre for Economics and Policy in Health: Bangor University, Centre for Health Information Research and Evaluation: Swansea University, Clinical Psychology, Community Mental Health, Consort Checklist for REMCARE Study, Cornell Scale for Depression in Dementia (CSDD), Cost-Effectiveness, Cost-Effectiveness Analyses, Cost-Effectiveness in Health Care, Cost-Utility Analyses, Dementia Care Research Faculty of Health and Social Care: University of Hull, Dementia Services Development Centre Wales: Bangor University, Division of Psychiatry: University College London, Family Carers, General Health Questionnaire (GHQ-28), Group Reminiscence Therapy, Hospital Anxiety and Depression Scale (HADS), Hull, Institute of Mental Health: University of Nottingham, ISRCTN Registry No. ISRCTN42430123, Joint Interventions, Joint Reminiscence Groups, Manchester, NHS Community Mental Health, NHS Memory Clinics, North Wales Organisation for Randomised Trials in Health and Social Care: Bangor University, Nottingham, ORCID, People With Dementia and Family Carers, PLoS One, Professor Martin Orrell, Psychological Distress in Carers, Quality of Life and Relationship Quality for People With Dementia, Quality of the Carer–Patient Relationship (QCPR), Rating Anxiety In Dementia (RAID), Relative's Stress Scale, REMCARE Trial, REMCARE: Pragmatic Multi-Centre Randomised Trial of Reminiscence Groups for People with Dementia and their Family Carers, REMCARE: Reminiscence Groups for People With Dementia and Their Family Caregivers, Reminiscence, Reminiscence and Sensory Stimulation, Reminiscence Groups for People with Dementia, Reminiscence Services, Reminiscence Therapy, School of Nursing Midwifery and Social Work: University of Manchester, Self-Reported Quality of Life For Persons With Dementia (QoL-AD), Swansea, Swansea University, University College London, University of Bradford, University of Hull, University of Manchester, University of Nottingham, West Wales Organisation for Rigorous Trials in Health: Swansea University, Ystrad Mynach Hospital (Caerphilly) | Leave a comment

Early Diagnosis of Parkinson’s Disease and DLB Using CSF Biomarker? (BBC News / Annals of Clinical and Translational Neurology)

Posted on August 30, 2016 by Dementia and Elderly Care News

Summary Research at the University of Edinburgh indicates that test for synuclein, which measures how sticky this protein molecule has become (i.e. alpha-synuclein aggregation), might be the key to diagnosing accurately the early stages of both Parkinson’s Disease and Dementia … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Parkinson's Disease, Scotland, UK, Universal Interest | Tagged Abnormal Proteins (Alpha-Synuclein), Alpha-Synuclein Aggregation, Alpha-Synuclein RT-QuIC, Alpha-Synucleinopathies, Annals of Clinical and Translational Neurology, BBC Health News, Biomarker Development, Biomarkers, Biomarkers Research Programmes, Brain Bank Network (MRC), Brains for Dementia Research (BDR), Centre for Clinical Brain Sciences: Western General Hospital, Cerebrospinal Fluid Biomarkers for Parkinson's Disease Diagnosis, Creutzfeldt Jacob Disease (CJD), Creutzfeldt-Jakob Disease (CJD), Creutzfeldt-Jakob Disease in United Kingdom Patients Treated With Human Pituitary Growth Hormone, CSF Biomarkers, Dementia With Lewy Bodies (DLB), Department of Physiology Anatomy and Genetics: University of Oxford, Diagnosis, Diagnosis and Screening: Dementia with Lewy Bodies, Differential Diagnosis, DLB: Dementia with Lewy Bodies, Early Diagnosis, Early Diagnosis of Lewy Body Dementia (LBD), Early Diagnosis of Parkinson’s Disease, Early Diagnosis of Parkinson’s Disease and DLB, Edinburgh Brain Bank, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, John Radcliffe Hospital, Lewy Body Degeneration, Lewy Body Dementia, Lewy Body Dementia (LBD), Medical Research Council (MRC), Michael J Fox Foundation, Misfolded Proteins, Monument Trust Discovery Award (Parkinson's UK), MRC Brain Bank, National CJD Research and Surveillance Unit (NCJDRSU), National CJD Surveillance Unit: Western General Hospital: Data Release (HSCIC), National Institute for Health Research (NIHR), National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, NCJDRSU: National CJD Research and Surveillance Unit, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Nuffield Department of Clinical Neurosciences: University of Oxford, OPDC Discovery Cohort, OPTIMA Cohort, OPTIMA Cohort (Oxford Project to Investigate Memory and Ageing), Oxford Brain Bank, Oxford Parkinson's Disease Centre, Oxford Parkinson's Disease Centre (OPDC) Discovery Study, Oxford Parkinson's Disease Centre: University of Oxford, Preclinical Biomarkers and Dementia, Prion-Like Mechanisms, Real-Time Quaking-Induced Conversion (RT-QuIC) Based Assay, Scottish Government's Chief Scientists Office, Sporadic Creutzfeldt-Jakob Disease, Synucleinopathies, Synucleinopathy, Synucleinopathy Progression, UK Brain Banks Network, UK Parkinson’s Disease Society Brain Bank Clinical Diagnostic Criteria, Underlying Mechanisms of DLB Pathogenesis, University of Edinburgh, University of Oxford, Western General Hospital: Edinburgh | Leave a comment

New Drugs for Dementia (POST Note PN 535)

Posted on August 29, 2016 by Dementia and Elderly Care News

Summary The Parliamentary Office of Science and Technology (POST) has produced a briefing outlining some of the challenges in developing new drugs for dementia, explained in the context of ongoing UK and international research programmes. There is an extensive bibliography, … Continue reading →

Posted in Alzheimer's Society, Alzheimer’s Research UK, Antipsychotics, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Models of Dementia Care, National, Pharmacological Treatments, Quick Insights, Statistics, UK, Universal Interest | Tagged Academic Institutes in the UK, Academy of Social Sciences, Aducanumab (Biogen), Alzheimer’s Association, Alzheimer’s Research UK’s Drug Discovery Alliance, Behavioural and Psychological Symptoms of Dementia (BPSD), Big Data, Big Data Funding and Research, Big Pharma, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, BPSD: Behavioral and Psychological Symptoms of Dementia, British Psychological Society (BPS), Co-ordination and Data Analytics, Cognitive Health in Ageing Register for Investigations, Collaborative Projects, Collaborative Research, Dementia Consortium, Dementia Risk Prevention, Dementias Platform UK, Dementias Platform UK (DPUK), Dementias Platform UK: MRC, Disease Modifying Treatment by 2025 (Aim), Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU), DPUK: Dementias Platform UK, Drug Discovery Alliance, Drug Licensing Approval, Drugs for BPSD, Drugs for Cognitive Symptoms of Cognitive Decline and Dementia, EAMS: Early Access to Medicines Scheme, Early Access to Medicines Scheme, Effective Non-Drug Interventions, Etanercept, European Prevention of Alzheimer's Dementia Consortium (EPAD), European Prevention of Alzheimer’s Dementia Consortium, Identification of People At Risk of Dementia, International Collaborations, International Programmes, International Research, Join Dementia Research, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, New Drugs for Dementia (POST Note PN 535), NIHR Clinical Research Network, Observations & Trials in Dementia Research, Parliament, Parliamentary Office of Science & Technology, Parliamentary Office of Science & Technology (POST), Participation in Research, Patient Access to New Drugs, Pharmaceutical Industry, Pioglitazone, POST: Parliamentary Office of Science & Technology, Pre-Symptomatic Diagnosis of Dementia, Preclinical Biomarkers and Dementia, Preclinical Indicators and Dementia, Prevention, Public Participation in Research, Research and Development, Research and Innovation, Research Commitment, Research Culture, Research Mapping, Research Networks, Solanezumab (Eli Lilly), Symptom-Modifying Drugs for Dementia, UK Dementia Research Institute, UK Parliament, UK Patient Recruitment Initiatives, Verubecestat (Merck), Well-Being and Health for People With Dementia (WHELD) Program | Leave a comment

NHS Reconfiguration + STPs = Cut-Backs?: Two Sides of Same Equation? (NHS England / King’s Fund / Nuffield Trust / BBC News)

Posted on August 28, 2016 by Dementia and Elderly Care News

Summary The “Keep calm and carry on”-style narrative from officialdom. Full Text Link Reference NHS England statement on Sustainability and Transformation Plans. [Online]: NHS England, August 26th 2016. Theoretical clarification concerning STPs, from the King’s Fund Full Text Link Reference … Continue reading →

Patterns in the Development of Alzheimer’s Disease? (NHS Choices / Science Advances)

Posted on August 26, 2016 by Dementia and Elderly Care News

Summary Patterns of gene activity (gene expression) in specific areas of the brain may help explain why Alzheimer’s Disease tends to start in certain regions before spreading further through the brain. “ …those regions of the brain in which tissues … Continue reading →

Posted in For Doctors (mostly), For Researchers (mostly), In the News, NHS Choices, Quick Insights, UK, Universal Interest | Tagged Abnormal Proteins, Abnormal Proteins (Tau), Aβ Accumulation, Aβ Seeds, Aβ-Plaques, Allen Brain Atlas, Allen Brain Atlas: 3-D Digital Images of Gene Expression, Amyloid and Tau Imaging, Amyloid Beta Protein, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Behind the Headlines, Braak Staging, Braak Staging of Alzheimer’s Disease, Department of Chemistry: University of Cambridge, Department of Molecular Biosciences: Northwestern University, Histopathological Staging of Alzheimer's Disease, Immune System, Immune System and Neurodegenerative Diseases, Levels of Genes Associated with Inflammation Mapped to Brain Areas, Mapping Brain Areas Affected in Early-Stage Alzheimer's Disease, Mapping Brain Areas Genetically Primed For Protein Overgrowth, Mapping Brain Areas Showing First Signs of Alzheimer's Disease, Mapping Brain Areas Susceptible to Protein Growth Due to Levels of Protein Expression, Mapping Brain Areas Vulnerable to Protein Overgrowth, Mapping Brain Areas: Allen Brain Atlas, Neurofibrillary Tangles, Northwestern University (USA), Pathological Staging, Patterns in the Development of Alzheimer’s Disease, Protein Aggregation, Protein Homeostasis, Protein Misfolding, Protein Overgrowth, Protein Plaques, Protein Seeds (Amyloid), Science Advances, Tau Aggregation, Tau Tangles, Tissue-Specific Progression of Alzheimer's Disease, University of Cambridge, USA, Vulnerability Patterns for Alzheimer's Disease | Leave a comment

Developments in Dementia Research: From the Horses’ Mouths (NHS England / NIHR)

Posted on August 25, 2016 by Dementia and Elderly Care News

Summary Professor Alistair Burns (NHS England’s National Clinical Director for Dementia and Older Peoples’ Mental Health), and Professor Martin Rossor (NIHR National Director for Dementia Research), discuss current issues and new approaches in dementia research, touching briefly upon some of … Continue reading →

Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Models of Dementia Care, National, NHS England, NIHR, Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged 100000 Genomes Project, A4 Study, Alistair Burns: Honorary Consultant Old Age Psychiatrist in the Manchester Mental Health and Social Care Trust (MMHSCT), Alistair Burns: NHS England’s National Clinical Director for Older People’s Mental Health, Alistair Burns: Professor of Old Age Psychiatry at University of Manchester, Alzheimer's Prevention Initiative, Alzheimer’s Disease Biomarkers, Alzheimer’s Prevention Initiative Study, Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study), APP and Presenilin, Asymptomatic Alzheimer’s Disease, Banner Alzheimer's Institute, Biomarkers, Chance Genetic Mutations, Colombia, Colombian Alzheimer's Prevention Initiative Registry in Medellín Antioquia, DIAN-TU Study, DIAN-TU Trial, Disease Modifying Treatment by 2025 (Aim), Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU), Early Detection of Alzheimer’s Disease, Early Detection of Preclinical Disease, Genentech, Genomics, Genomics England, Genomics in the NHS, Genomics-Based Medicine, Global Outlook, Identification of People At Risk of Dementia, International Collaborations, International Programmes, International Research, Medellin (Colombia), Monoclonal Antibodies, MRC Neurochemical Pharmacology Unit, Mutational Signatures, National Clinical Director for Dementia, National Institute for Health Research (NIHR), National Institutes of Health (NIH), National Institutes of Health (US), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, NIHR Clinical Research Network, NIHR Dementia Translational Research Collaboration, NIHR National Director for Dementia Research, NIHR Translational Research Collaboration, Overcoming Barriers, Participation in Research, Participation in Research Studies, Preclinical Alzheimer's Disease, Presenilin, Prodromal Alzheimer's Disease, Professor Alistair Burns, Professor Martin Rossor: Director of the NIHR Queen Square Dementia Biomedical Research Unit, Professor Martin Rossor: Former Director of the NIHR Dementia and Neurodegenerative Disease Research Network (DeNDRoN), Professor Martin Rossor: Former President of the Association of British Neurologists (2011-2013), Professor Martin Rossor: Honorary Consultant Neurologist at National Hospital for Neurology and Neurosurgery, Professor Martin Rossor: National Hospital (Queen Square), Professor Martin Rossor: NIHR National Director for Dementia Research, Professor Martin Rossor: UCL Institute of Neurology, Promisary Science, Reducing Downstream Effects of Disease, Research and Development, Research and Innovation, Research Commitment, Research Culture, Research Mapping, Research Networks, Research Promotion, Sharing Knowledge and Information, Slowing Progression of Disease (Stabilisation), Solanezumab (Sola or Solab), Solanezumab: Humanised Monoclonal Antibody, Therapeutic Nihilism (Avoiding), Translational Research, UK Genomes Project: Genomics England, University of Southern California’s Alzheimer’s Therapeutic Research Institute, Washington University School of Medicine | Leave a comment

Challenges in the Creation of a Seven-Day NHS: Leaked Update (BBC News)

Posted on August 23, 2016 by Dementia and Elderly Care News

Summary A confidential Department of Health review of government plans for a seven-day NHS in England, “leaked” to the Guardian newspaper and Channel 4 News, identifies 13 potential risks; including concerns over staff-shortages, workforce overload and the general lack of … Continue reading →

Monthly Archives: August 2016

Early Diagnosis of Parkinson’s Disease and DLB Using CSF Biomarker? (BBC News / Annals of Clinical and Translational Neurology)

Patterns in the Development of Alzheimer’s Disease? (NHS Choices / Science Advances)

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