Patterns of gene activity (gene expression) in specific areas of the brain may help explain why Alzheimer’s Disease tends to start in certain regions before spreading further through the brain.
“ …those regions of the brain in which tissues were more susceptible to protein expression correlated well with the brain regions that first show signs of Alzheimer’s disease”.
If Alzheimer’s Disease-related problems first become apparent in areas most genetically primed for protein overgrowth then future research into potential treatments might focus on these brain regions.
Gene patterns may explain brain’s Alzheimer’s vulnerability. London: NHS Choices; Behind the Headlines, August 11th 2016.
This relates to:
Freer, R. Sormanni, P. [and] Vecchi, G. [et al] (2016). A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease. Science Advances. August 10th 2016; 2(8): e1600947.