A decline in the sense of smell could be an early warning sign of cognitive decline. The Percepts of Odor Episodic Memory (POEM) test appears to identify clinically normal persons at higher risk for developing progressive memory symptoms characteristic of Alzheimer’s Disease / dementia.
Testing sense of smell may give early warning of Alzheimer’s risk. London: NHS Choices; Behind the Headlines, November 15th 2016.
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Albers, AD. Asafu-Adjei, J. [and] Delaney, MK. [et al] (2016). Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly. Annals of Neurology. October 1st 2016. [Epub ahead of print].