Another Recent Alzheimer’s Disease Drug Trial Disappointment (Lancet)

Summary

Researchers aimed to discover whether LMTM [Leuco-methylthioninium bis(hydromethanesulfonate] might be safe and effective for slowing disease progression in patients with mild to moderate Alzheimer’s Disease. LMTM had previously been found to work as a selective inhibitor of tau protein aggregation, in vitro and in transgenic mouse models.

Results from their 15-month randomised controlled double-blind trial, held at 115 centres in 16 countries, were negative; with no evident benefit of LMTM as an add-on treatment for patients with mild to moderate Alzheimer’s Disease.

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Reference

Gauthier, S. Feldman, HH. [and] Schneider, LS. [et al] (2016). Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer’s disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial. Lancet. November  15th 2016. [Epub ahead of print].

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Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
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