One of NHS Choices, Behind the Headlines‘ “Top News Stories of 2016”. It appears that people using proton pump inhibitors (PPIs) may have a 44% higher risk of developing dementia over a seven-year period.
“This finding is supported by recent pharmacoepidemiological analyses on primary data and is in line with mouse models in which the use of PPIs increased the levels of β-amyloid in the brains of mice”.
However, people taking PPIs had poorer health, were more likely to take other medicines and to have conditions associated with a higher risk of dementia. Avoidance of PPIs may help prevent the development of dementia, but more research is needed to be certain.
Link between indigestion drugs and dementia ‘inconclusive’. London: NHS Choices; Behind the Headlines, February 16th 2016.
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Gomm, W. von Holt, K. [and] Thomé, F. [et al] (2016). Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis. JAMA Neurology. April 2016; 73(4): 410-6.