Proton Pump Inhibitors Increase the Risk of Dementia? (NHS Choices / JAMA Neurology)


One of NHS Choices, Behind the Headlines‘ “Top News Stories of 2016”. It appears that people using proton pump inhibitors (PPIs) may have a 44% higher risk of developing dementia over a seven-year period.

“This finding is supported by recent pharmacoepidemiological analyses on primary data and is in line with mouse models in which the use of PPIs increased the levels of β-amyloid in the brains of mice”.

However, people taking PPIs had poorer health, were more likely to take other medicines and to have conditions associated with a higher risk of dementia. Avoidance of PPIs may help prevent the development of dementia, but more research is needed to be certain.

Full Text Link


Link between indigestion drugs and dementia ‘inconclusive’. London: NHS Choices; Behind the Headlines, February 16th 2016.

This relates to:

Full Text Link (Note: This article requires a suitable Athens password, a journal subscription or payment for access).


Gomm, W. von Holt, K. [and] Thomé, F. [et al] (2016). Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis. JAMA Neurology. April 2016; 73(4): 410-6.

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
This entry was posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, Statistics, Universal Interest and tagged , , , , , , , , , , , , , , , , , , , , , , , , , . Bookmark the permalink.

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