The Prevention of Alzheimer’s Disease by Vitamin E and Selenium (PREADViSE) trial investigated the potential use of antioxidant supplementation (whether Vitamin E and / or selenium) for the prevention of dementia in asymptomatic older men. This study has now concluded that neither Vitamin E or selenium, nor the combination of these supplements, prevents dementia.
Kryscio, RJ. Abner, EL. [and] Caban-Holt, A. [et al] (201). Association of antioxidant supplement use and dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE). JAMA Neurology. March 20th 2017. [Epub ahead of print].