Lower Cognitive Impairment / Dementia With Oral Anticoagulants For Atrial Fibrillation (European Heart Journal / NHS Choices / Neurology)

Summary

Swedish researchers have discovered that anticoagulant treatment for atrial fibrillation is associated with a 29% lower risk of dementia.

“The risk of dementia is higher without oral anticoagulant treatment in patients with AF. This suggests that early initiation of anticoagulant treatment in patients with AF could be of value in order to preserve cognitive function”.

There was apparently no difference between use of NOACs and warfarin.

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Reference

Friberg, L. [and] Rosenqvist, M. (2017). Less dementia with oral anticoagulation in atrial fibrillation. European Heart Journal. October 24^th 2017, ehx579. [Epub ahead of print].

The following NHS Choices Behind the Headlines critical appraisal offers more light on the subject:

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Reference

Blood-thinning drugs may reduce dementia risk in people with irregular heartbeats. London: NHS Choices; Behind the Headlines, October 25^th 2017.

October 2018 Update

A Swedish study appears to confirm that while atrial fibrillation is associated with faster cognitive decline and an increased risk of dementia in older people, the use of anticoagulant drugs (but not antiplatelets) may help reduce dementia risk.

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Reference

Ding, M. Fratiglioni, L. [and] Johnell, K. [et al]. (2018). Atrial fibrillation, antithrombotic treatment, and cognitive aging: a population-based study. Neurology. October 10^th 2018. [Epub ahead of print].

May 2019 Update: Lower Dementia and Stroke Risk

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Reference

Friberg, L. Andersson, T. Rosenqvist, M. (2019). Less dementia and stroke in low-risk patients with atrial fibrillation taking oralanticoagulation. European Heart Journal. May 16^th 2019. [Epub ahead of print].