A systematic review and meta‐analysis of pharmaceutical treatments for alleviating agitation in dementia has been performed. Regarding the efficacy and treatment acceptability of these medications, it is reported that:
“Risperidone, SSRIs as a class and Dextromethorphan / Quinidine demonstrated evidence of efficacy for agitation in dementia, although findings for Dextromethorphan / Quinidine were based on a single RCT. Our findings do not support prescribing Haloperidol due to lack of efficacy, or Oxcarbazepine due to lack of acceptability. The decision to prescribe should be based on comprehensive consideration of the benefits and risks… ”.
Kongpakwattana, K. Swangjit, R. [and] Tawankanjanachot, I. [et al] (2018). Pharmacological treatments for alleviating agitation in dementia: a systematic review and network meta-analysis. British Journal of Clinical Pharmacology. April 10th 2018. [Epub ahead of print].