The “Goal-oriented cognitive Rehabilitation in Early-stage Alzheimer’s and related dementias: multicentre single-blind randomised controlled Trial (GREAT)” was designed to discover whether individual goal-oriented cognitive rehabilitation might improve everyday functioning in people living with mild-to-moderate dementia. It found a significant large positive effect in terms of participant-rated goal attainment (at least).
Clare, L. Kudlicka, A. [and] Oyebode, JR. [et al] (2019). Goal-oriented cognitive rehabilitation for early-stage Alzheimer’s and related dementias: the GREAT RCT. Health Technology Assessment. March 2019; 23(10): 1-242.
Note: There were no significant benefits detectable from the more objective / directly measurable secondary outcome measures:
“Secondary outcomes at 3 and 9 months included informant-reported goal attainment, quality of life, mood, self-efficacy, and cognition and study partner stress and quality of life”.
Clare, L. Kudlicka, A. [and] Oyebode, JR. [et al] (2019). Individual goal-oriented cognitive rehabilitation to improve everyday functioning for people with early-stage dementia: A multicentre randomised controlled trial (the GREAT trial). International Journal of Geriatric Psychiatry. February 6th 2019. [Epub ahead of print].