Unexpected Results From the Dementia and Physical Activity (DAPA) Trial? (Pharmacoeconomics Open / JAD)


Previous research has suggested that physical exercise has the potential to slow the progression of dementia in people with pre-existing mild cognitive impairment through to moderate dementia. Evidence for the cost-effectiveness of structured physical activity programmes has been lacking, so far, however.

The current study, conducted from the UK NHS and personal social services perspective with backing from the National Institute of Health Research’s Health Technology Assessment (NIHR HTA) programme, compared the cost-effectiveness of a “tailored, structured, moderate- to high-intensity exercise programme versus usual care in people with mild to moderate dementia”.

The particular structured exercise programme evaluated here did not slow rates of cognitive decline in people with mild cognitive impairment or moderate dementia. Accordingly the economic evaluation found that the programme was not cost-effective.

Full Text Link


Khan, I. Petrou, S. Khan, K. [et al]; DAPA Trial Group (2019). Does structured exercise improve cognitive impairment in people with mild to moderate dementia? A cost-effectiveness analysis from a confirmatory randomised controlled trial: the Dementia and Physical Activity (DAPA) Trial. Pharmacoeconomics Open. June 2019; 3(2): pp.215-227.


Similarly inconclusive results regarding the benefits of Exergaming (exercise and gaming), as yet:

Full Text Link


van Santen, J. Dröes, RM. [and] Holstege, M. [et al] (2019). Effects of Exergaming in people with dementia: results of a systematic literature review. Journal of Alzheimer’s Disease. 2018; 63(2): pp.741-760.

About Dementia and Elderly Care News

Dementia and Elderly Care News. Wolverhampton Medical Institute: WMI. (jh)
This entry was posted in Commissioning, Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), For Social Workers (mostly), Local Interest, Management of Condition, Models of Dementia Care, National, NHS, NIHR, Non-Pharmacological Treatments, Personalisation, Quick Insights, Statistics, UK, Universal Interest, Wolverhampton and tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , . Bookmark the permalink.

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