Persons in the UK Biobank study were followed over time to discover whether pursuing a healthy lifestyle (not smoking, regular physical activity, healthy diet and moderate alcohol consumption) might be associated with lower risk of developing dementia regardless of predisposing genetic risk factors. Statistically, favourable (“healthy”) lifestyles were found to be associated with lower dementia incidence even among persons at high genetic risk.
Gallagher, J. (2019). Dementia: Lifestyle changes that could lower your risk. London: BBC Health News, July 14th 2019.
This relates to:
Lourida, I. Hannon, E. [and] Littlejohns, TJ. [et al] (2019). Association of lifestyle and genetic risk with incidence of dementia. Journal of the American Medical Association (JAMA). July 14th 2019. [Epub ahead of print].
A readable critical appraisal exists:
“About 1.1% of those with a high genetic risk but a healthy lifestyle developed dementia, compared to about 1.8% of those with high genetic risk and an unhealthy lifestyle. This represented about a 32% reduction in risk of developing dementia”.
Healthy lifestyle reduces dementia risk even in those with genetic risk factors. London: NHS Digital (previously NHS Choices); Behind the Headlines, July 15th 2019.