More on the Possible Role of Neuroinflammation in Frontotemporal Dementia (Bazian / Brain)

Summary

Inflammation in the brain has been found to be present alongside (“co-localised” with) protein clusters in patients with frontotemporal dementia, suggesting that neuroinflammation may be involved as a potential cause of frontotemporal dementia.

“The researchers found that both the C-PK-11195 marker for inflammation, and F-AV-1451 marker for protein clusters, were more common in the front (frontal) and sides (temporal) of the brain in people with frontotemporal dementia than the healthy comparison group”.

The following NHS Digital Behind the Headlines critical appraisal interprets this research impartially.

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Reference

Brain inflammation linked to uncommon type of ‘early-onset’ dementia. London: NHS Digital; Behind the Headlines, March 18^th 2020.

This relates to:

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Reference

Bevan-Jones, WR. Cope, TE. [and] Jones, PS. [et al] (2020). Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum. Brain. March 17^th 2020. [Epub ahead of print].