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Category Archives: Parkinson’s Disease
Further Research Backs Speculation Linking the Immune System and Parkinson’s Disease (BBC News / Nature)
Summary Further evidence has emerged suggesting that malfunctioning in the body’s immune system may contribute to the development and progression of Parkinson’s Disease. T-cells appear to attack alpha-synuclein – a protein which accumulates in Parkinson’s Disease – after confusing this … Continue reading
Posted in BBC News, For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Quick Insights, Universal Interest
Tagged Abnormal Proteins (Alpha-Synuclein), Adrienne Helis Malvin Medical Research Foundation (New Orleans), Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Australia, Autoimmune Attacks, BBC Health News, Brain and Immune System, Columbia University, Cytotoxic T Cell Responses, Department of Microbiology and Immunology: University of Oklahoma, Department of Neurology: Columbia University, Department of Pharmacology and Molecular Sciences: Johns Hopkins University School of Medicine, Department of Pharmacology: Columbia University, Department of Physiology: Johns Hopkins University School of Medicine, Departments of Psychiatry: Columbia University, Division of Molcular Therapeutics: New York State Psychiatric Institute, Division of Vaccine Discovery: La Jolla Institute for Allergy and Immunology, Histocompatibility Complex Alleles, Immune System, Immune System and Parkinson's Disease, Inflammation, Inflammation and Neurodegenerative Diseases, Institute for Cell Engineering and the Department of Neurology: Johns Hopkins University School of Medicine, Institute for Immunology and Infectious Diseases: Murdoch University, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, α-Synuclein Peptides, Johns Hopkins University School of Medicine, La Jolla Institute for Allergy and Immunology, Murdoch University (Perth; Western Australia), Nature, Nervous System and Immune System, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neuroregeneration and Stem Cell Program: Johns Hopkins University School of Medicine, New York State Psychiatric Institute, Novel Targets in Neurodegeneration, Solomon H. Snyder Department of Neuroscience: Johns Hopkins University School of Medicine, T-Cells, United States, University of Oklahoma, USA
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Updated Compendium of Patient Information on Parkinson’s Disease (Michael J. Fox Foundation / Parkinson’s UK)
Summary It is two years since the previous version of this collection, and some significant new patient guides have come to light, from both the USA and the UK. The Michael J. Fox Foundation for Parkinson’s Research offers an interesting … Continue reading
Posted in Charitable Bodies, Diagnosis, For Carers (mostly), For Nurses and Therapists (mostly), International, Management of Condition, Non-Pharmacological Treatments, Parkinson's Disease, Patient Information, Person-Centred Care, Personalisation, Pharmacological Treatments, Practical Advice, Quick Insights, UK, Universal Interest
Tagged Advice and Information, Amantadine, Anticholinergic Drugs, Anticholinergics, Carbidopa, Caregiving (Carers), Carer's Allowance, Complementary and Alternative Therapies for Parkinson’s Disease, Decarboxylase Inhibitor, Deep Brain Stimulation, Deep Brain Stimulation (DBS), Deep Brain Stimulation in Parkinson's Disease, Diet and Parkinson's Disease, Dopamine Agonists, Dopamine Releaser / Antiglutamatergic Medication, Drug Treatments for Parkinson's: Parkinson’s UK, Incontinence, Information and Advice Services, Information and Signposting Services, Information Needs of Carers, Information Needs of Patients, Living Well With Parkinson's Disease, Local Group Finance Guide: Parkinson’s UK, MAO-B Inhibitors, Michael J. Fox Foundation for Parkinson’s Research, Navigating Parkinson's Disease, NHS Evidence, Nocturia, Orthostatic Hypotension, Parkinson's Disease Psychosis, Parkinson’s 360º: Michael J. Fox Foundation, Parkinson’s Disease Dementia, Parkinson’s Disease Medications, Parkinson’s Disease: Complementary and Alternative Therapies, Parkinson’s Disease: Motor Medications and Associated Complications in Early - Middle Years, Parkinson’s Disease: Motor Medications and Associated Complications in Middle - Advancing Years, Parkinson’s Disease: Non-Motor Medications, Parkinson’s UK, Parkinson’s UK (Parkinsons Disease Society), Parkinsonian Symptoms, Participation in Research, Patient Involvement in Research, Public Participation in Research, Real Talk for Patients and Families (Michael J. Fox Foundation), Signposting, Signposting Patient Information, Signposting Services and Knowledge, Signposting to Sources of Practical Help, Tremor and Parkinson's Disease, Tremor and Parkinson's: Parkinson’s UK Fact Sheet No.94, Urinary Incontinence in Neurological Disease, USA, Using Computers and the Internet : Parkinson’s UK Fact Sheet No. FS60, Voices of People Living With Parkinson's Disease
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Earlier Diagnosis of Glaucoma – and Possibly Many Neurodegenerative Diseases – By Retinal Examination? (BBC News / NHS Choices / Brain)
Summary A fluorescent dye injected into the bloodstream may, in future, provide a convenient method of detecting glaucoma earlier – perhaps a decade before more overt symptoms and damage have had the opportunity to develop – by identifying changes in … Continue reading
Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, NHS Choices, Parkinson's Disease, Quick Insights, UK, Universal Interest
Tagged Annexin 5 Labelled With Fluorescent Dye DY-776 (ANX776), ANX776 Pharmacokinetics and Pharmacodynamics, ANX776-Positive Fluorescent Cells, Apoptosis, Apoptotic Cells in Neurodegenerative Diseases, Apoptotic Neural Cell Death, Assessment and Diagnosis, BBC Health News, Behind the Headlines, Bethan Hughes: Wellcome Trust, Brain (Journal), Centre for Medical Image Computing: University College London, DARC: Detection of Apoptosing Retinal Cells, Dementia Diagnosis, Department of Visual Neuroscience: UCL Institute of Ophthalmology, Detection of Apoptosing Retinal Cells (DARC), Diagnostic Imaging, Diagnostic Markers, Diagnostic Testing, Drusen (Spots on Retina), Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Early Diagnosis of Parkinson’s Disease, Eye Cells, Eye Examinations, Glaucoma, Glaucoma and Retinal Neurodegeneration Group: UCL Institute of Ophthalmology, Glaucomatous Neurodegeneration, Imperial College London, Imperial College Ophthalmic Research Group (ICORG), Intravenous ANX776, Levels of Apoptosis (DARC Count), London, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuronal Cell Apoptosis in Patients With Glaucoma, Neuronal Loss, Ocular Neurodegenerative Conditions, Potential of DARC as Surrogate Biomarker. Retinal Ganglion Cell Apoptosis, Retinal Assessments Using DARC (Detection of Apoptosing Retinal Cells), Retinal Cell Apoptosis, Retinal Ganglion Cell Layer, Retinal Nerve Fibre Layer (RNFL), Timely Diagnosis, Translational Imaging Group: University College London, UCL Institute of Ophthalmology, University College London, Western Eye Hospital, Western Eye Hospital: Imperial College Healthcare NHS Trust, Western Eye Hospital: Imperial College Healthcare NHS Trust (ICHNT)
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On the Road to Dementia? (BBC / Lancet / NHS Choices)
Summary Researchers following nearly 2 million Canadians in Ontario over 11 years have discovered that living close to busy roads appears to be associated with a higher incidence of dementia. It is suggested that possibly 10% of dementia cases amongst … Continue reading
Posted in BBC News, Community Care, For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Choices, Parkinson's Disease, Quick Insights, Statistics, Universal Interest
Tagged Air Pollution, Air Pollution and Public Health, Air Pollution and Risk of Dementia, Air Pollution From Motor Exhaust Fumes, Air Quality, Airborne Particulate Matter, BBC Health News, Behind the Headlines, Canada, Canadian Health Databases, Carleton University (Ottawa), Cognitive Impairment (Potential Risk Factors), College of Public Health and Human Sciences: Oregon State University, Combustion-Derived Nanoparticles, Dalhousie University, Dalla Lana School of Public Health: University of Toronto, Department of Family and Community Medicine: University of Toronto, Department of Health Sciences: Carleton University (Ottawa), Department of Medicine: University of Toronto, Department of Physics and Atmospheric Science: Dalhousie University, Division of Neurology: University of Toronto, Environmental Risk Factors, Epidemiology, Epidemiology and Statistics, Evidence for Risk Factors of Dementia, Exposure to Air Pollution and Cognitive Functioning, Exposure to Fine Particulate Matter, Exposure to Traffic, Harvard-Smithsonian Centre for Astrophysics, Health Canada, Heavy Traffic, Institute for Clinical Evaluative Sciences (Toronto), Lancet, Life Expectancy: Variations Between Rural and Urban Areas in England, Living Close To Busy Roads, Living Within 50 Metres of a Major Road, Long-Term Exposure to Ambient Air Pollution, Modifiable Risk Factors, Multiple Sclerosis, Near-Road Exposure and Risk of Dementia, Neurodegeneration, Neurodegenerative Diseases, Neurodegenerative Disorders, Nitrogen Oxides (NOx), Noise Pollution, Ontario (Canada), Oregon State University, Population Studies Division: Health Canada, Potentially Modifiable Socio-Environmental Risk Factors for Dementia, Prof. Andy Jones: Professor of Public Health at University of East Anglia, Prof. David Newby: British Heart Foundation Professor of Cardiology at University of Edinburgh, Prof. Tom Dening: Centre for Dementia at University of Nottingham, Professor Martin Rossor: NIHR National Director for Dementia Research, Public Health, Public Health Ontario, Residence Near to Busy Roads, Residential Proximity To Major Roadways, Rurality, Small Particulate Matter (PM2.5), Statistical Digest of Rural England (2012), Sunnybrook Health Sciences Centre: University of Toronto, Ultrafine Particles, University of Toronto, Urban Environment, USA
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Possibly a Paradigm Shift in the Understanding of Parkinson’s Disease? (BBC News / Cell / NHS Choices)
Summary Animal research in the United States and Sweden suggests that Parkinson’s Disease may be caused by bacteria living in the gut. It appears likely that the certain gut bacteria (the “gut microbiome”) could be responsible for releasing chemicals (SCFAs) … Continue reading
Posted in Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Choices, Parkinson's Disease, Quick Insights, Universal Interest
Tagged Abnormal Proteins (Alpha-Synuclein), Alpha-Synucleinopathies, Arizona State University, BBC Health News, Behind the Headlines, Biodesign Institute: Arizona State University, Biology and Biological Engineering Department: Chalmers University of Technology, California Institute of Technology, Cell (Journal), Chalmers University of Technology (Gothenburg), Chalmers University of Technology (Sweden), David Geffen School of Medicine at UCLA, Department of Computer Science and Engineering: University of California, Department of Internal Medicine: Rush University Medical Center, Department of Neurological Sciences: Rush University Medical Center, Department of Neurology: The David Geffen School of Medicine at UCLA, Department of Pediatrics: University of California, Division of Biology and Biological Engineering: California Institute of Technology, Division of Gastroenterology: Rush University Medical Center, Early Parkinson Disease, Genetically Engineered Mice, Gut Bacteria, Gut Microbes, Gut Microbiome, Gut Microbiota, Human Gut Microbiome: a Potential Risk Factor for Parkinson's Disease, Immune Cells (Microglia), Inflammation, Inflammation and Neurodegenerative Diseases, Intestinal Microbiota, α-Syn-Overexpressing Mice, α-Synuclein, α-Synuclein Aggregation, Knut and Alice Wallenberg Foundation, Mice, Microbiota Transplants, Microglia, Motor Deficits, Neuroinflammation, Parkinson’s Disease Pathogenesis, Risk Factors, Risk Factors for Parkinson's Disease, Rush University Medical Center, Rush University Medical Center: Chicago, Section of Movement Disorders: Rush University Medical Center, Short-Chain Fatty Acids (SFCAs), Sweden, Swedish Research Council, Swette Center for Environmental Biotechnology: Biodesign Institute, Synucleinopathies, United States, University of California, USA
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