Category Archives: Pharmacological Treatments

Elderly Major Trauma Patients: Guidelines (London Major Trauma System / Emergency Medicine Journal)

Summary The 11.5 million people aged 65 and older is the fastest growing age group in the UK They comprise 18% of the population today, and this figure is projected to rise to 25% of the population by 2040. According … Continue reading

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Proton Pump Inhibitors Increase the Risk of Dementia? (NHS Choices / JAMA Neurology)

Summary One of NHS Choices, Behind the Headlines‘ “Top News Stories of 2016”. It appears that people using proton pump inhibitors (PPIs) may have a 44% higher risk of developing dementia over a seven-year period. “This finding is supported by … Continue reading

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BBC iWonder Guide: How Close Are We to Stopping Alzheimer’s Disease? (BBC News)

Summary The BBC’s iWonder Guides provide “thought-provoking answers to the questions sparked by everyday life”. This particular collection of brief digestible articles, animations and videos covers: A frightening prospect (epidemiological statistics). How the disease affects your brain cells (an interactive … Continue reading

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Another Recent Alzheimer’s Disease Drug Trial Disappointment (Lancet)

Summary Researchers aimed to discover whether LMTM [Leuco-methylthioninium bis(hydromethanesulfonate] might be safe and effective for slowing disease progression in patients with mild to moderate Alzheimer’s Disease. LMTM had previously been found to work as a selective inhibitor of tau protein … Continue reading

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Alzheimer’s Disease: Solanezumab Drug Trial Flops (BBC News / Alzheimer’s and Dementia)

Summary The phase 3 EXPEDITION3 trial has been abandoned, as Solanezumab failed to slow cognitive decline in tests on around 2,000 patients with Alzheimer’s Disease. Several other amyloid-clearance drugs are going through trials apparently. Full Text Link Reference Walsh, F. … Continue reading

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Missed Opportunities in Stroke Prevention (University of Birmingham / PLoS Medicine / European Journal of Neurology)

Summary Analysis of the records of UK patients who suffered a stroke indicates that over half of people who should have received drugs to prevent strokes had not been prescribed such medicines. Full Text Link Reference Research suggests ‘missed opportunities’ … Continue reading

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Early Promising Signs in Verubecestat Human Drug Trial (NHS Choices / Science Translational Medicine / Translational Neurodegeneration)

Summary Early results from a Phase I trial indicate that the BACE1 inhibitor Verubecestat may effectively reduce β-amyloid formation in human patients with Alzheimer’s Disease. This appears to confirm previous trials with rats, monkeys and healthy young human adults. As … Continue reading

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