Tag Archives: α-Synuclein Aggregation

Further Research Supports Speculation of Link Between Gut and Parkinson’s Disease (BBC News / Science Translational Medicine)

Posted on November 2, 2018 by Dementia and Elderly Care News

Summary Further evidence implying that the gut may be involved in the development of Parkinson’s Disease has emerged. Toxic (alpha-synuclein) proteins associated with Parkinson’s Disease tend to accumulate in the appendix, and it seems that people who have had their … Continue reading →

Posted in BBC News, For Doctors (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Quick Insights, Universal Interest | Tagged Abnormal Proteins (Alpha-Synuclein), Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Appendectomy Associated With Delayed Age of Parkinson’s Disease, Appendectomy Associated With Lower Risk of Parkinson’s Disease, Appendix Contains Truncated α-synuclein Proteoforms, Appendix Lysates, BBC Health News, Benefits of Missing Appendix, Canada, Center for Neurodegenerative Science: Van Andel Research Institute, Centre for Addiction and Mental Health (Toronto), Centre National de la Recherche Scientifique Gif sur Yvette, College of Human Medicine: Michigan State University, Department of Clinical Sciences Psychiatry: Lund University, Department of Epidemiology and Biostatistics: Michigan State University, Epidemiology, Epidemiology and Statistics, Faculty of Medicine: Lund University, France, Healthy Human Appendix Contains α-synuclein, Human Gut (Appendix): a Potential Risk Factor for Parkinson's Disease, α-Synuclein, α-Synuclein Aggregation, Lund University, Michigan State University, Northwestern University (Evanston), Paris-Saclay Institute of Neuroscience: Centre National de la Recherche Scientifique, Parkinson’s Disease Pathogenesis, Parkinson’s Disease Risk and Appendix (Gut), Parkinson’s Progression Markers Initiative (PPMI), Prodromal Parkinson's Disease, Proteomics Center of Excellence: Northwestern University, Psychiatric Clinic (Lund), Risk Factors, Risk Factors for Parkinson's Disease, Science Translational Medicine, Statistics Sweden, Sweden, Swedish National Patient Registry (SNPR), Synucleinopathy Progression, United States, USA, Van Andel Research Institute, Vermiform Appendix, Vermiform Appendix and Risk of Parkinson’s Disease | Leave a comment

The Most Significant Breakthrough in the Treatment of Neurodegenerative Diseases in Fifty Years? (BBC News / UCL)

Posted on December 15, 2017 by Dementia and Elderly Care News

Summary An experimental drug for the treatment of Huntington’s Disease shows early signs of being able to lower the level of misfolded proteins (safely) in the brains of patients, thereby having the potential to slow or halt the progression of … Continue reading →

Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Parkinson's Disease, Quick Insights, UK, Universal Interest | Tagged Alzheimer's Disease, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Antisense Oligonucleotides (ASO), Biomedical Research Centres (NIHR), Canada, Clinical Trial NCT02519036, Gene Silencing to Suppress Transcription and Translation of Huntingtin, Gene-Silencing, Genetic Research, Genetics, Germany, Huntingtin Protein, Huntingtin Protein (HTT), Huntington Disease, Huntington's Disease (HD): an Autosomal-Dominant Inherited Neurodegenerative Disorder, Huntington's Disease Centre: UCL Institute of Neurology, Huntington’s Disease, Ionis Pharmaceuticals, IONIS-HTTRx: Huntingtin-Lowering Drug, α-Synuclein, α-Synuclein Aggregation, Leonard Wolfson Experimental Neurology Centre (LWENC), Leonard Wolfson Experimental Neurology Centre: University College London, Misfolded Proteins, Mutant HTT (mHTT) Protein, Mutant Huntingtin (mHTT), National Institute for Health Research (NIHR), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuronal Loss, Neuroprotection, Prof. Giovanna Mallucci, Professor Sarah Tabrizi: IONIS-HTTRx Global Chief Investigator, Professor Sarah Tabrizi: UCL Institute of Neurology, Protein Misfolding, Roche, Synucleinopathy, Tau, Tau Protein, Tauopathy, University College London (UCL), University College London Hospitals Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, University College London Hospitals NHS Foundation Trust / University College London (NIHR) Biomedical Research Centre | Leave a comment

Dementia with Lewy Bodies: Updated DLB Consortium Diagnosis and Management Consensus Report (Neurology)

Posted on July 13, 2017 by Dementia and Elderly Care News

Summary The Dementia with Lewy Bodies (DLB) Consortium has published an updated set of recommendations on diagnosis and management of DLB. Clinical features and diagnostic biomarkers are covered, with guidance on their interpretation. Previously omitted aspects of Lewy-related pathology are … Continue reading →

Posted in Antipsychotics, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Management of Condition, Mental Health, Models of Dementia Care, Non-Pharmacological Treatments, Person-Centred Care, Quick Insights, UK | Tagged Abnormal Proteins (Alpha-Synuclein), Acting Out Dreams: Rapid Eye Movement (REM) Sleep Behaviour Disorder, Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Alternatives to Antipsychotics, Antipsychotics Limitation in Dementia, Antipsychotics: Neuroleptic Sensitivity, Assessment and Diagnosis, Australia, Autonomic System Dysfunction, Banner Sun Health Research Institute, Behavior and Mood Changes, Behavioral and Psychological Symptoms of Dementia (BPSD), Behavioural and Psychological Symptoms of Dementia (BPSD), Biomarker Development, Biomarkers, Biomarkers Research Programmes, Blackouts, Brain and Mind Centre: University of Sydney, Brain Stimulation, Center for Neurodegenerative Disease Research: University of Pennsylvania, Centre for Age-Related Diseases: Stavanger University Hospital, Cognitive Decline (DLB vs. Alzheimer's), Cognitive Symptoms, Comparison of Cognitive Decline (DLB vs. AD), Deep Brain Stimulation for the Treatment of Dementia, Delusions, Dementia With Lewy Bodies (DLB), Dementia With Lewy Bodies (DLB) Consortium, Department of Laboratory Medicine and Pathology: Mayo Clinic, Department of Neurology: Mayo Clinic, Department of Neurology: Mayo Clinic (Rochester), Department of Neurology: University of Pennsylvania, Department of Neuroscience and Neuropathology Laboratory: Mayo Clinic, Department of Neuroscience Imaging and Clinical Sciences: University G. d'Annunzio of Chieti-Pescara, Department of Neuroscience: Mayo Clinic, Department of Psychiatry and Psychology: Mayo Clinic, Department of Veterans Affairs, Departments of Radiology and Neurology: University of Michigan, Diagnosis and Management of Dementia with Lewy Bodies, Diagnosis and Screening: Dementia with Lewy Bodies, Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-V), Differential Diagnosis, Dizziness, DLB, DLB Management, DLB: Dementia with Lewy Bodies, Drooling, DSM-5, Early Diagnosis, Early Diagnosis of Lewy Body Dementia (LBD), Early Diagnosis of Parkinson’s Disease and DLB, Fainting, Florida Atlantic University, Fluctuating Cognition, Fluctuations, Fourth Consensus Report of DLB Consortium, Hallucinations, Handwriting, ICube Laboratory, Institute for Healthy Aging and Lifespan Studies (I-HeAL): Florida Atlantic University, Institute of Neuroscience: Newcastle University, Institute of Psychiatry Psychology and Neuroscience: King’s College London, Italy, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, Kings College London, Lewy Body Degeneration, Lewy Body Dementia, Lewy Body Dementia (LBD), Lewy Body Dementia Symptoms Checklists, Lewy Body Society, Medical School: University of Exeter; University of Exeter, Misdiagnosis, Mood Changes, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroleptic Sensitivity, Neurology (Journal), Norway, Parkinson's Disease and Mental Illness Research Education and Clinical Centers (PADRECC and MIRECC): Philadelphia Veterans Affairs Medical Center, Parkinson’s-Like Symptoms, Perelman School of Medicine: University of Pennsylvania, Philadelphia Veterans Affairs Medical Center, Postural Instability, Preclinical Biomarkers and Dementia, Prion-Like Mechanisms, Repeated Falls, Severe Neuroleptic Sensitivity, Severe Sensitivity to Antipsychotic Agents, Shuffling Walk, Sleep Disorders Center: Mayo Clinic, Stavanger University Hospital, Stavanger University Hospital; Norway, Synucleinopathies, Synucleinopathy, Synucleinopathy Progression, Transient Loss of Consciousness, Underlying Mechanisms of DLB Pathogenesis, United States, University G. d'Annunzio of Chieti-Pescara, University Hospital of Strasbourg, University of Michigan, University of Pennsylvania, University of Strasbourg, University of Sydney | Leave a comment

Further Research Backs Speculation Linking the Immune System and Parkinson’s Disease (BBC News / Nature)

Posted on June 23, 2017 by Dementia and Elderly Care News

Summary Further evidence has emerged suggesting that malfunctioning in the body’s immune system may contribute to the development and progression of Parkinson’s Disease. T-cells appear to attack alpha-synuclein – a protein which accumulates in Parkinson’s Disease – after confusing this … Continue reading →

Posted in BBC News, For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Quick Insights, Universal Interest | Tagged Abnormal Proteins (Alpha-Synuclein), Adrienne Helis Malvin Medical Research Foundation (New Orleans), Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Australia, Autoimmune Attacks, BBC Health News, Brain and Immune System, Columbia University, Cytotoxic T Cell Responses, Department of Microbiology and Immunology: University of Oklahoma, Department of Neurology: Columbia University, Department of Pharmacology and Molecular Sciences: Johns Hopkins University School of Medicine, Department of Pharmacology: Columbia University, Department of Physiology: Johns Hopkins University School of Medicine, Departments of Psychiatry: Columbia University, Division of Molcular Therapeutics: New York State Psychiatric Institute, Division of Vaccine Discovery: La Jolla Institute for Allergy and Immunology, Histocompatibility Complex Alleles, Immune System, Immune System and Parkinson's Disease, Inflammation, Inflammation and Neurodegenerative Diseases, Institute for Cell Engineering and the Department of Neurology: Johns Hopkins University School of Medicine, Institute for Immunology and Infectious Diseases: Murdoch University, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, α-Synuclein Peptides, Johns Hopkins University School of Medicine, La Jolla Institute for Allergy and Immunology, Murdoch University (Perth; Western Australia), Nature, Nervous System and Immune System, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neuroregeneration and Stem Cell Program: Johns Hopkins University School of Medicine, New York State Psychiatric Institute, Novel Targets in Neurodegeneration, Solomon H. Snyder Department of Neuroscience: Johns Hopkins University School of Medicine, T-Cells, United States, University of Oklahoma, USA | Leave a comment

Grounds for Cautious Optimism Regarding Two Drugs Re-Purposed for Neurodegenerative Diseases? (BBC News / MRC / NHS Choices / Brain)

Posted on April 20, 2017 by Dementia and Elderly Care News

Summary Animal research, involving mice, has indicated promising results for the potential of two re-purposed drugs in helping to slow or halt the progression of a number of neurodegenerative brain diseases, including dementia. “The best known drug of the pair … Continue reading →

Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, National, NHS Digital (Previously NHS Choices), Parkinson's Disease, Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged Abnormal Prion Protein, Alzheimer's Disease, Alzheimer's Research UK, Alzheimer’s Drug Discovery Foundation, Alzheimer’s Research UK (ARUK), Alzheimer’s Research UK Drug Discovery Institute, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Autoimmune Attacks, Autoimmune Cell Defences, BBC Health News, Behind the Headlines, Brain (Journal), Centre for Analytical Bioscience: University of Nottingham, CJD, Creutzfeldt-Jakob Disease, Creuzfeldt Jacob Disease (CJD), Department of Clinical Neurosciences: University of Cambridge, Dibenzoylmethane, Dibenzoylmethane (DBM): Potential Anti-Cancer Drug, Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Dr David Dexter: Parkinson's UK, Dr Doug Brown: Director of Research and Development at Alzheimer's Society, Drug Discovery Programmes, eIF2a-P-Mediated Translational Repression (Pathway of Neurodegeneration), Frontotemporal Dementia (FTD), Huntingtin Protein, Huntington’s Disease, α-Synuclein, α-Synuclein Aggregation, Lentivirally Mediated RNA Interference (RNAi), Medical Research Council (MRC), Medical Research Council (UK), Medical Research Council Toxicology Unit: University of Leicester, Medical Research Council’s (MRC) Toxicology Unit, Microscopic Worms, Misfolded Prion Protein (PrP), Misfolded Proteins, Motor Neurone Disease (MND), MRC Toxicology Unit: University of Leicester, MRC: Medical Research Council, Multiple Sclerosis, National Institute for Neurological Disorders and Stroke, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuronal Loss, Neuroprotection, Parkinson's, Potential Repurposing of Drugs to Slow Progression of Alzheimer’s Disease, Prion Diseases, Prion Protein (PrP(C)), Prion-Infected Mice, Prof. Giovanna Mallucci, Professor Giovanna Mallucci: Associate Drector of UK Dementia Research Institute, Protein Misfolding, Rare Prion Diseases, Repurposing of Drugs, Synucleinopathy, Tau, Tau Protein, Tauopathy, Translational Research, Transmissible Spongiform Encephalopathies, Trazodone, Trazodone Hydrochloride (Antidepressant), UK Dementia Research Institute, UK Dementia Research Institute (UK DRI), Unfolded Protein Response (UPR), University of Cambridge, University of Leicester, University of Nottingham, Worms: C. elegans | Leave a comment

Possibly a Paradigm Shift in the Understanding of Parkinson’s Disease? (BBC News / Cell / NHS Choices)

Posted on December 5, 2016 by Dementia and Elderly Care News

Summary Animal research in the United States and Sweden suggests that Parkinson’s Disease may be caused by bacteria living in the gut. It appears likely that the certain gut bacteria (the “gut microbiome”) could be responsible for releasing chemicals (SCFAs) … Continue reading →

Posted in Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Parkinson's Disease, Quick Insights, Universal Interest | Tagged Abnormal Proteins (Alpha-Synuclein), Alpha-Synucleinopathies, Arizona State University, BBC Health News, Behind the Headlines, Biodesign Institute: Arizona State University, Biology and Biological Engineering Department: Chalmers University of Technology, California Institute of Technology, Cell (Journal), Chalmers University of Technology (Gothenburg), Chalmers University of Technology (Sweden), David Geffen School of Medicine at UCLA, Department of Computer Science and Engineering: University of California, Department of Internal Medicine: Rush University Medical Center, Department of Neurological Sciences: Rush University Medical Center, Department of Neurology: The David Geffen School of Medicine at UCLA, Department of Pediatrics: University of California, Division of Biology and Biological Engineering: California Institute of Technology, Division of Gastroenterology: Rush University Medical Center, Early Parkinson Disease, Genetically Engineered Mice, Gut Bacteria, Gut Microbes, Gut Microbiome, Gut Microbiota, Human Gut Microbiome: a Potential Risk Factor for Parkinson's Disease, Immune Cells (Microglia), Inflammation, Inflammation and Neurodegenerative Diseases, Intestinal Microbiota, α-Syn-Overexpressing Mice, α-Synuclein, α-Synuclein Aggregation, Knut and Alice Wallenberg Foundation, Mice, Microbiota Transplants, Microglia, Motor Deficits, Neuroinflammation, Parkinson’s Disease Pathogenesis, Risk Factors, Risk Factors for Parkinson's Disease, Rush University Medical Center, Rush University Medical Center: Chicago, Section of Movement Disorders: Rush University Medical Center, Short-Chain Fatty Acids (SFCAs), Sweden, Swedish Research Council, Swette Center for Environmental Biotechnology: Biodesign Institute, Synucleinopathies, United States, University of California, USA | Leave a comment

Early Diagnosis of Parkinson’s Disease and DLB Using CSF Biomarker? (BBC News / Annals of Clinical and Translational Neurology)

Posted on August 30, 2016 by Dementia and Elderly Care News

Summary Research at the University of Edinburgh indicates that test for synuclein, which measures how sticky this protein molecule has become (i.e. alpha-synuclein aggregation), might be the key to diagnosing accurately the early stages of both Parkinson’s Disease and Dementia … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Parkinson's Disease, Scotland, UK, Universal Interest | Tagged Abnormal Proteins (Alpha-Synuclein), Alpha-Synuclein Aggregation, Alpha-Synuclein RT-QuIC, Alpha-Synucleinopathies, Annals of Clinical and Translational Neurology, BBC Health News, Biomarker Development, Biomarkers, Biomarkers Research Programmes, Brain Bank Network (MRC), Brains for Dementia Research (BDR), Centre for Clinical Brain Sciences: Western General Hospital, Cerebrospinal Fluid Biomarkers for Parkinson's Disease Diagnosis, Creutzfeldt Jacob Disease (CJD), Creutzfeldt-Jakob Disease (CJD), Creutzfeldt-Jakob Disease in United Kingdom Patients Treated With Human Pituitary Growth Hormone, CSF Biomarkers, Dementia With Lewy Bodies (DLB), Department of Physiology Anatomy and Genetics: University of Oxford, Diagnosis, Diagnosis and Screening: Dementia with Lewy Bodies, Differential Diagnosis, DLB: Dementia with Lewy Bodies, Early Diagnosis, Early Diagnosis of Lewy Body Dementia (LBD), Early Diagnosis of Parkinson’s Disease, Early Diagnosis of Parkinson’s Disease and DLB, Edinburgh Brain Bank, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, John Radcliffe Hospital, Lewy Body Degeneration, Lewy Body Dementia, Lewy Body Dementia (LBD), Medical Research Council (MRC), Michael J Fox Foundation, Misfolded Proteins, Monument Trust Discovery Award (Parkinson's UK), MRC Brain Bank, National CJD Research and Surveillance Unit (NCJDRSU), National CJD Surveillance Unit: Western General Hospital: Data Release (HSCIC), National Institute for Health Research (NIHR), National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, NCJDRSU: National CJD Research and Surveillance Unit, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Nuffield Department of Clinical Neurosciences: University of Oxford, OPDC Discovery Cohort, OPTIMA Cohort, OPTIMA Cohort (Oxford Project to Investigate Memory and Ageing), Oxford Brain Bank, Oxford Parkinson's Disease Centre, Oxford Parkinson's Disease Centre (OPDC) Discovery Study, Oxford Parkinson's Disease Centre: University of Oxford, Preclinical Biomarkers and Dementia, Prion-Like Mechanisms, Real-Time Quaking-Induced Conversion (RT-QuIC) Based Assay, Scottish Government's Chief Scientists Office, Sporadic Creutzfeldt-Jakob Disease, Synucleinopathies, Synucleinopathy, Synucleinopathy Progression, UK Brain Banks Network, UK Parkinson’s Disease Society Brain Bank Clinical Diagnostic Criteria, Underlying Mechanisms of DLB Pathogenesis, University of Edinburgh, University of Oxford, Western General Hospital: Edinburgh | Leave a comment

Tag Archives: α-Synuclein Aggregation

Further Research Supports Speculation of Link Between Gut and Parkinson’s Disease (BBC News / Science Translational Medicine)

The Most Significant Breakthrough in the Treatment of Neurodegenerative Diseases in Fifty Years? (BBC News / UCL)

Further Research Backs Speculation Linking the Immune System and Parkinson’s Disease (BBC News / Nature)

Grounds for Cautious Optimism Regarding Two Drugs Re-Purposed for Neurodegenerative Diseases? (BBC News / MRC / NHS Choices / Brain)

Possibly a Paradigm Shift in the Understanding of Parkinson’s Disease? (BBC News / Cell / NHS Choices)

Early Diagnosis of Parkinson’s Disease and DLB Using CSF Biomarker? (BBC News / Annals of Clinical and Translational Neurology)

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