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Tag Archives: α-Synuclein Aggregation
Further Research Supports Speculation of Link Between Gut and Parkinson’s Disease (BBC News / Science Translational Medicine)
Summary Further evidence implying that the gut may be involved in the development of Parkinson’s Disease has emerged. Toxic (alpha-synuclein) proteins associated with Parkinson’s Disease tend to accumulate in the appendix, and it seems that people who have had their … Continue reading
Posted in BBC News, For Doctors (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Quick Insights, Universal Interest
Tagged Abnormal Proteins (Alpha-Synuclein), Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Appendectomy Associated With Delayed Age of Parkinson’s Disease, Appendectomy Associated With Lower Risk of Parkinson’s Disease, Appendix Contains Truncated α-synuclein Proteoforms, Appendix Lysates, BBC Health News, Benefits of Missing Appendix, Canada, Center for Neurodegenerative Science: Van Andel Research Institute, Centre for Addiction and Mental Health (Toronto), Centre National de la Recherche Scientifique Gif sur Yvette, College of Human Medicine: Michigan State University, Department of Clinical Sciences Psychiatry: Lund University, Department of Epidemiology and Biostatistics: Michigan State University, Epidemiology, Epidemiology and Statistics, Faculty of Medicine: Lund University, France, Healthy Human Appendix Contains α-synuclein, Human Gut (Appendix): a Potential Risk Factor for Parkinson's Disease, α-Synuclein, α-Synuclein Aggregation, Lund University, Michigan State University, Northwestern University (Evanston), Paris-Saclay Institute of Neuroscience: Centre National de la Recherche Scientifique, Parkinson’s Disease Pathogenesis, Parkinson’s Disease Risk and Appendix (Gut), Parkinson’s Progression Markers Initiative (PPMI), Prodromal Parkinson's Disease, Proteomics Center of Excellence: Northwestern University, Psychiatric Clinic (Lund), Risk Factors, Risk Factors for Parkinson's Disease, Science Translational Medicine, Statistics Sweden, Sweden, Swedish National Patient Registry (SNPR), Synucleinopathy Progression, United States, USA, Van Andel Research Institute, Vermiform Appendix, Vermiform Appendix and Risk of Parkinson’s Disease
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The Most Significant Breakthrough in the Treatment of Neurodegenerative Diseases in Fifty Years? (BBC News / UCL)
Summary An experimental drug for the treatment of Huntington’s Disease shows early signs of being able to lower the level of misfolded proteins (safely) in the brains of patients, thereby having the potential to slow or halt the progression of … Continue reading
Posted in BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Parkinson's Disease, Quick Insights, UK, Universal Interest
Tagged Alzheimer's Disease, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Antisense Oligonucleotides (ASO), Biomedical Research Centres (NIHR), Canada, Clinical Trial NCT02519036, Gene Silencing to Suppress Transcription and Translation of Huntingtin, Gene-Silencing, Genetic Research, Genetics, Germany, Huntingtin Protein, Huntingtin Protein (HTT), Huntington Disease, Huntington's Disease (HD): an Autosomal-Dominant Inherited Neurodegenerative Disorder, Huntington's Disease Centre: UCL Institute of Neurology, Huntington’s Disease, Ionis Pharmaceuticals, IONIS-HTTRx: Huntingtin-Lowering Drug, α-Synuclein, α-Synuclein Aggregation, Leonard Wolfson Experimental Neurology Centre (LWENC), Leonard Wolfson Experimental Neurology Centre: University College London, Misfolded Proteins, Mutant HTT (mHTT) Protein, Mutant Huntingtin (mHTT), National Institute for Health Research (NIHR), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuronal Loss, Neuroprotection, Prof. Giovanna Mallucci, Professor Sarah Tabrizi: IONIS-HTTRx Global Chief Investigator, Professor Sarah Tabrizi: UCL Institute of Neurology, Protein Misfolding, Roche, Synucleinopathy, Tau, Tau Protein, Tauopathy, University College London (UCL), University College London Hospitals Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, University College London Hospitals NHS Foundation Trust / University College London (NIHR) Biomedical Research Centre
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Further Research Backs Speculation Linking the Immune System and Parkinson’s Disease (BBC News / Nature)
Summary Further evidence has emerged suggesting that malfunctioning in the body’s immune system may contribute to the development and progression of Parkinson’s Disease. T-cells appear to attack alpha-synuclein – a protein which accumulates in Parkinson’s Disease – after confusing this … Continue reading
Posted in BBC News, For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Quick Insights, Universal Interest
Tagged Abnormal Proteins (Alpha-Synuclein), Adrienne Helis Malvin Medical Research Foundation (New Orleans), Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Australia, Autoimmune Attacks, BBC Health News, Brain and Immune System, Columbia University, Cytotoxic T Cell Responses, Department of Microbiology and Immunology: University of Oklahoma, Department of Neurology: Columbia University, Department of Pharmacology and Molecular Sciences: Johns Hopkins University School of Medicine, Department of Pharmacology: Columbia University, Department of Physiology: Johns Hopkins University School of Medicine, Departments of Psychiatry: Columbia University, Division of Molcular Therapeutics: New York State Psychiatric Institute, Division of Vaccine Discovery: La Jolla Institute for Allergy and Immunology, Histocompatibility Complex Alleles, Immune System, Immune System and Parkinson's Disease, Inflammation, Inflammation and Neurodegenerative Diseases, Institute for Cell Engineering and the Department of Neurology: Johns Hopkins University School of Medicine, Institute for Immunology and Infectious Diseases: Murdoch University, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, α-Synuclein Peptides, Johns Hopkins University School of Medicine, La Jolla Institute for Allergy and Immunology, Murdoch University (Perth; Western Australia), Nature, Nervous System and Immune System, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neuroregeneration and Stem Cell Program: Johns Hopkins University School of Medicine, New York State Psychiatric Institute, Novel Targets in Neurodegeneration, Solomon H. Snyder Department of Neuroscience: Johns Hopkins University School of Medicine, T-Cells, United States, University of Oklahoma, USA
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Possibly a Paradigm Shift in the Understanding of Parkinson’s Disease? (BBC News / Cell / NHS Choices)
Summary Animal research in the United States and Sweden suggests that Parkinson’s Disease may be caused by bacteria living in the gut. It appears likely that the certain gut bacteria (the “gut microbiome”) could be responsible for releasing chemicals (SCFAs) … Continue reading
Posted in Animal Studies, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Parkinson's Disease, Quick Insights, Universal Interest
Tagged Abnormal Proteins (Alpha-Synuclein), Alpha-Synucleinopathies, Arizona State University, BBC Health News, Behind the Headlines, Biodesign Institute: Arizona State University, Biology and Biological Engineering Department: Chalmers University of Technology, California Institute of Technology, Cell (Journal), Chalmers University of Technology (Gothenburg), Chalmers University of Technology (Sweden), David Geffen School of Medicine at UCLA, Department of Computer Science and Engineering: University of California, Department of Internal Medicine: Rush University Medical Center, Department of Neurological Sciences: Rush University Medical Center, Department of Neurology: The David Geffen School of Medicine at UCLA, Department of Pediatrics: University of California, Division of Biology and Biological Engineering: California Institute of Technology, Division of Gastroenterology: Rush University Medical Center, Early Parkinson Disease, Genetically Engineered Mice, Gut Bacteria, Gut Microbes, Gut Microbiome, Gut Microbiota, Human Gut Microbiome: a Potential Risk Factor for Parkinson's Disease, Immune Cells (Microglia), Inflammation, Inflammation and Neurodegenerative Diseases, Intestinal Microbiota, α-Syn-Overexpressing Mice, α-Synuclein, α-Synuclein Aggregation, Knut and Alice Wallenberg Foundation, Mice, Microbiota Transplants, Microglia, Motor Deficits, Neuroinflammation, Parkinson’s Disease Pathogenesis, Risk Factors, Risk Factors for Parkinson's Disease, Rush University Medical Center, Rush University Medical Center: Chicago, Section of Movement Disorders: Rush University Medical Center, Short-Chain Fatty Acids (SFCAs), Sweden, Swedish Research Council, Swette Center for Environmental Biotechnology: Biodesign Institute, Synucleinopathies, United States, University of California, USA
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Lancet Seminar on Parkinson’s Disease (Lancet / Advances in Integrative Medicine / Translational Proteomics / Parkinson’s UK / BBC News)
Summary Coinciding with Parkinson’s Awareness Week 2015 (April 20th – 26th 2015), the following Lancet review / seminar covers the clinical features, risk factors, pathology, genetics, pathogenesis, diagnosis and treatment of Parkinson’s Disease. Full Text Link (Note: This article requires … Continue reading
Posted in Acute Hospitals, BBC News, Charitable Bodies, Community Care, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Non-Pharmacological Treatments, Parkinson's Disease, Pharmacological Treatments, Quick Insights, Scotland, Systematic Reviews, UK, Universal Interest
Tagged Abnormal Prion Protein, Abnormal Proteins (Alpha-Synuclein), Abnormal Proteins (Prions), Acting Out Dreams: Rapid Eye Movement (REM) Sleep Behaviour Disorder, Advances in Integrative Medicine, Association of RBD with Synucleinopathies, BBC Health News, Biomarkers, Braak Model, Braak Staging of Lewy Pathology in Parkinson’s Disease, Canada, CHCHD2, CIND-PD: Cognitive Impairment in Parkinson's Disease, Clinical Symptoms and Time Course of Parkinson’s Disease Progression, Complications of Dopaminergic Therapies for Parkinson’s Disease, Deep Brain Stimulation (DBS), Dementia in Parkinson's Disease, Department of Human Protein Sciences: Geneva University Hospitals, Department of Neurology: Geneva University Hospitals, DNAJC13, Dopamine, Dopamine Replacement Therapy (DRT), Dreaming in Dementia: REM Sleep Behaviour Disorder and Synucleinopathy, Drug Treatments for Parkinson’s Disease, Early Parkinson Disease, Edmond J Safra Program in Parkinson’s Disease: Toronto Western Hospital, EIF4G1, Faculty of Medicine: Geneva University Hospitals, Falls in Parkinson's Disease, Genetics of Parkinson's Disease, Geneva University Hospitals, Institute of Neurological Sciences in Glasgow, α-Synuclein, α-Synuclein Aggregation, Lancet, Lewy Body Parkinson Disease, LRRK2, LRRK2: Leucine-Rich Repeat Kinase 2 Gene, Monogenic Forms of Parkinson’s Disease (By Gene), Morton and Gloria Shulman Movement Disorders Clinic: Toronto Western Hospital, National Deep Brain Stimulation Service for Scotland, National Service in Scotland: NHS DBS Centres in Scotland, National Specialist Services Committee (Scotland), Neuroproteomics Group: Geneva University Hospitals, NHS DBS Centres in England, Non-Motor Fluctuations in Parkinson's Disease, Parkin (PARK2), Parkinson's Awareness Week, Parkinson’s Awareness Week (2015), Parkinson’s Disease Awareness Week (2015), Parkinson’s Disease Dementia, Parkinson’s Disease Diagnosis, Parkinson’s Disease Pathogenesis, Parkinson’s UK, Parkinson’s UK (Parkinsons Disease Society), Parkinson’s-Like Symptoms, Parkinsonian Symptoms, Parkinsonism, PDD: Parkinson's Disease with Dementia, Prion Diseases, Prion Protein, Proteomic Profiling of Parkinson's Disease-Relevant Brain Regions, Proteomics, Rapid Eye Movement (REM) Sleep Behaviour Disorder, Rapid Eye Movement (REM) Sleep Disorder, Rapid Eye Movement Sleep Behaviour Disorder (RBD), RBD: Rapid Eye Movement Sleep Behaviour Disorder, SNCA, SNCA: α-Synuclein Gene, Switzerland, Synucleinopathies, Synucleinopathy, Toronto Western Hospital, Translational Proteomics, UK Parkinson’s Disease Society Brain Bank Clinical Diagnostic Criteria, University Medical Center: Geneva University Hospitals, University of Toronto, VPS35
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Skin Cells: A New Non-Invasive Biomarker? (BBC News / American Academy of Neurology)
Summary Skin may be a good candidate biomarker for detecting hidden brain disorders earlier. Abnormal proteins which accumulate in the brain in neurodegenerative disorders such as Alzheimer’s Disease and Parkinson’s Disease can be found in the skin too. Research is … Continue reading
Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Quick Insights, Universal Interest
Tagged Abnormal Proteins, Abnormal Proteins (Alpha-Synuclein), Abnormal Proteins (Tau), Alzheimer's Disease: Diagnosis, American Academy of Neurology, American Academy of Neurology’s 67th Annual Meeting (Washington 2015), Assessment and Diagnosis, BBC Health News, Biomarkers, Central Hospital at the University of San Luis Potosi, Dementia Diagnosis, Diagnostic Markers, Diagnostic Testing, Differential Diagnosis, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Early Differential Diagnosis, α-Synuclein, α-Synuclein Aggregation, Mexico, National Council of Science and Technology of Mexico, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Non-Invasive Biomarkers, Parkinson’s Disease Diagnosis, Parkinsonism, Post-Mortem Studies, Skin Biopsies, Skin Cells, Skin Tests, Synucleinopathy, Tau, Tau Pathology, Tau Protein, Timely Diagnosis, University of San Luis Potosi (Mexico)
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