Tag Archives: α-Synuclein Misfolds

Further Brief Insights Into the Potentially Neuroprotective Benefits of Certain Foods (BBC News / Scientific Reports / ARUK / AAIC)

Posted on April 28, 2018 by Dementia and Elderly Care News

Summary There is evidence to suggest that the protein β-parvalbumin found in fish inhibits the formation of α-synuclein (the protein present in Parkinson’s Disease). The cross-reaction of β-parvalbumin and human amyloidogenic proteins may explain at least some of the health … Continue reading →

Posted in Alzheimer’s Research UK, Charitable Bodies, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Nutrition, Parkinson's Disease, Quick Insights, Statistics, UK, Universal Interest | Tagged 2017 Alzheimer’s Association International Conference (AAIC®2017), Abnormal Proteins (Alpha-Synuclein), Alpha-Synucleinopathies, Alzheimer's and Dementia: The Journal of the Alzheimer's Association, Alzheimer’s Association, Alzheimer’s Association AAIC Press Office, Alzheimer’s Association International Conference (AAIC®2017), Alzheimer’s Research UK (ARUK), Amyloidogenic Proteins, Anti-Inflammatory (Foods), Antioxidants, ARUK: Alzheimer’s Research UK, Baltic Sea Diet, Berries, Beta-Carotene, Beta-Parvalbumin, Blueberries, BSD (Baltic Sea Diet), Chalmers University of Technology, Cognitive Performance in Older US Adults: Health and Retirement Study, Columbia University, CoSTREAM Project: EU's Horizon 2020 Research and Innovation Programme, DASH (Dietary Approaches to Stop Hypertension), Dementia Prevention, Dementia Risk Factors, Dementia Risk Prevention, Dementia Risk Reduction, Dementia Risk Reduction and Prevention, Department of Biology and Biological Engineering: Chalmers University of Technology, Diet, Diet and Dementia, Dietary Approaches to Stop Hypertension (DASH) Diets, Dietary Behaviour, Dietary Factors, Dietetic Input, Dr David Reynolds: Alzheimer's Research UK, Eating Leafy Greens, Environmental Risk Factors, Epidemiology, Epidemiology and Statistics, Fish, Fish Consumption, Flavonoids, Health and Retirement Study (HRS), Health and Retirement Study (US), Healthy Behaviours, Healthy Eating, Healthy Lifestyles, Healthy Living, Healthy Nordic Diet, HRS: Health and Retirement Study, Inflammation-Related Nutrient Pattern (INP), Inflammatory Nutrient Pattern Associated With Cognitive Brain Ageing, α-Synuclein, α-Synuclein Misfolds, β-Parvalbumin, Karolinska Institute, Karolinska Institutet, Leafy Greens, Lifestyle Risk Factors, Mediterranean and DASH (Dietary Approaches to Stop Hypertension) Diets, Mediterranean Diet, Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND Diets), Modifiable Risk Factors, National Institutes of Health / National Institutes on Aging, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroprotection, Neuroprotection Research, Neuroprotective Agents, Neuroprotective Dietary Patterns Associated With Better Cognitive Performance, Neuroprotective Diets, Neuroprotective Lifestyles, Nordic Prudent Diet Reduces Risk of Cognitive Decline, Nordic Prudent Dietary Pattern (NPDP), Parkinson’s Disease Pathogenesis, Poor Diet Linked to Inflammation, Prevention, Prevention Agenda, Prevention of Dementia, Prevention of Parkinson’s Disease, Sweden, Synucleinopathy, The Health and Retirement Study, US National Institute on Aging, Wake Forest School of Medicine in Winston-Salem (North Carolina), Women Who Eat Well Less Likely to Develop Dementia, Women’s Health Initiative Memory Study (WHIMS) | Leave a comment

Dementia with Lewy Bodies: Updated DLB Consortium Diagnosis and Management Consensus Report (Neurology)

Posted on July 13, 2017 by Dementia and Elderly Care News

Summary The Dementia with Lewy Bodies (DLB) Consortium has published an updated set of recommendations on diagnosis and management of DLB. Clinical features and diagnostic biomarkers are covered, with guidance on their interpretation. Previously omitted aspects of Lewy-related pathology are … Continue reading →

Posted in Antipsychotics, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Management of Condition, Mental Health, Models of Dementia Care, Non-Pharmacological Treatments, Person-Centred Care, Quick Insights, UK | Tagged Abnormal Proteins (Alpha-Synuclein), Acting Out Dreams: Rapid Eye Movement (REM) Sleep Behaviour Disorder, Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Alternatives to Antipsychotics, Antipsychotics Limitation in Dementia, Antipsychotics: Neuroleptic Sensitivity, Assessment and Diagnosis, Australia, Autonomic System Dysfunction, Banner Sun Health Research Institute, Behavior and Mood Changes, Behavioral and Psychological Symptoms of Dementia (BPSD), Behavioural and Psychological Symptoms of Dementia (BPSD), Biomarker Development, Biomarkers, Biomarkers Research Programmes, Blackouts, Brain and Mind Centre: University of Sydney, Brain Stimulation, Center for Neurodegenerative Disease Research: University of Pennsylvania, Centre for Age-Related Diseases: Stavanger University Hospital, Cognitive Decline (DLB vs. Alzheimer's), Cognitive Symptoms, Comparison of Cognitive Decline (DLB vs. AD), Deep Brain Stimulation for the Treatment of Dementia, Delusions, Dementia With Lewy Bodies (DLB), Dementia With Lewy Bodies (DLB) Consortium, Department of Laboratory Medicine and Pathology: Mayo Clinic, Department of Neurology: Mayo Clinic, Department of Neurology: Mayo Clinic (Rochester), Department of Neurology: University of Pennsylvania, Department of Neuroscience and Neuropathology Laboratory: Mayo Clinic, Department of Neuroscience Imaging and Clinical Sciences: University G. d'Annunzio of Chieti-Pescara, Department of Neuroscience: Mayo Clinic, Department of Psychiatry and Psychology: Mayo Clinic, Department of Veterans Affairs, Departments of Radiology and Neurology: University of Michigan, Diagnosis and Management of Dementia with Lewy Bodies, Diagnosis and Screening: Dementia with Lewy Bodies, Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-V), Differential Diagnosis, Dizziness, DLB, DLB Management, DLB: Dementia with Lewy Bodies, Drooling, DSM-5, Early Diagnosis, Early Diagnosis of Lewy Body Dementia (LBD), Early Diagnosis of Parkinson’s Disease and DLB, Fainting, Florida Atlantic University, Fluctuating Cognition, Fluctuations, Fourth Consensus Report of DLB Consortium, Hallucinations, Handwriting, ICube Laboratory, Institute for Healthy Aging and Lifespan Studies (I-HeAL): Florida Atlantic University, Institute of Neuroscience: Newcastle University, Institute of Psychiatry Psychology and Neuroscience: King’s College London, Italy, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, Kings College London, Lewy Body Degeneration, Lewy Body Dementia, Lewy Body Dementia (LBD), Lewy Body Dementia Symptoms Checklists, Lewy Body Society, Medical School: University of Exeter; University of Exeter, Misdiagnosis, Mood Changes, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroleptic Sensitivity, Neurology (Journal), Norway, Parkinson's Disease and Mental Illness Research Education and Clinical Centers (PADRECC and MIRECC): Philadelphia Veterans Affairs Medical Center, Parkinson’s-Like Symptoms, Perelman School of Medicine: University of Pennsylvania, Philadelphia Veterans Affairs Medical Center, Postural Instability, Preclinical Biomarkers and Dementia, Prion-Like Mechanisms, Repeated Falls, Severe Neuroleptic Sensitivity, Severe Sensitivity to Antipsychotic Agents, Shuffling Walk, Sleep Disorders Center: Mayo Clinic, Stavanger University Hospital, Stavanger University Hospital; Norway, Synucleinopathies, Synucleinopathy, Synucleinopathy Progression, Transient Loss of Consciousness, Underlying Mechanisms of DLB Pathogenesis, United States, University G. d'Annunzio of Chieti-Pescara, University Hospital of Strasbourg, University of Michigan, University of Pennsylvania, University of Strasbourg, University of Sydney | Leave a comment

Further Research Backs Speculation Linking the Immune System and Parkinson’s Disease (BBC News / Nature)

Posted on June 23, 2017 by Dementia and Elderly Care News

Summary Further evidence has emerged suggesting that malfunctioning in the body’s immune system may contribute to the development and progression of Parkinson’s Disease. T-cells appear to attack alpha-synuclein – a protein which accumulates in Parkinson’s Disease – after confusing this … Continue reading →

Posted in BBC News, For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Quick Insights, Universal Interest | Tagged Abnormal Proteins (Alpha-Synuclein), Adrienne Helis Malvin Medical Research Foundation (New Orleans), Alpha-Synuclein Aggregation, Alpha-Synucleinopathies, Australia, Autoimmune Attacks, BBC Health News, Brain and Immune System, Columbia University, Cytotoxic T Cell Responses, Department of Microbiology and Immunology: University of Oklahoma, Department of Neurology: Columbia University, Department of Pharmacology and Molecular Sciences: Johns Hopkins University School of Medicine, Department of Pharmacology: Columbia University, Department of Physiology: Johns Hopkins University School of Medicine, Departments of Psychiatry: Columbia University, Division of Molcular Therapeutics: New York State Psychiatric Institute, Division of Vaccine Discovery: La Jolla Institute for Allergy and Immunology, Histocompatibility Complex Alleles, Immune System, Immune System and Parkinson's Disease, Inflammation, Inflammation and Neurodegenerative Diseases, Institute for Cell Engineering and the Department of Neurology: Johns Hopkins University School of Medicine, Institute for Immunology and Infectious Diseases: Murdoch University, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, α-Synuclein Peptides, Johns Hopkins University School of Medicine, La Jolla Institute for Allergy and Immunology, Murdoch University (Perth; Western Australia), Nature, Nervous System and Immune System, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurodegenerative Research, Neuroregeneration and Stem Cell Program: Johns Hopkins University School of Medicine, New York State Psychiatric Institute, Novel Targets in Neurodegeneration, Solomon H. Snyder Department of Neuroscience: Johns Hopkins University School of Medicine, T-Cells, United States, University of Oklahoma, USA | Leave a comment

Early Diagnosis of Parkinson’s Disease and DLB Using CSF Biomarker? (BBC News / Annals of Clinical and Translational Neurology)

Posted on August 30, 2016 by Dementia and Elderly Care News

Summary Research at the University of Edinburgh indicates that test for synuclein, which measures how sticky this protein molecule has become (i.e. alpha-synuclein aggregation), might be the key to diagnosing accurately the early stages of both Parkinson’s Disease and Dementia … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Parkinson's Disease, Scotland, UK, Universal Interest | Tagged Abnormal Proteins (Alpha-Synuclein), Alpha-Synuclein Aggregation, Alpha-Synuclein RT-QuIC, Alpha-Synucleinopathies, Annals of Clinical and Translational Neurology, BBC Health News, Biomarker Development, Biomarkers, Biomarkers Research Programmes, Brain Bank Network (MRC), Brains for Dementia Research (BDR), Centre for Clinical Brain Sciences: Western General Hospital, Cerebrospinal Fluid Biomarkers for Parkinson's Disease Diagnosis, Creutzfeldt Jacob Disease (CJD), Creutzfeldt-Jakob Disease (CJD), Creutzfeldt-Jakob Disease in United Kingdom Patients Treated With Human Pituitary Growth Hormone, CSF Biomarkers, Dementia With Lewy Bodies (DLB), Department of Physiology Anatomy and Genetics: University of Oxford, Diagnosis, Diagnosis and Screening: Dementia with Lewy Bodies, Differential Diagnosis, DLB: Dementia with Lewy Bodies, Early Diagnosis, Early Diagnosis of Lewy Body Dementia (LBD), Early Diagnosis of Parkinson’s Disease, Early Diagnosis of Parkinson’s Disease and DLB, Edinburgh Brain Bank, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, John Radcliffe Hospital, Lewy Body Degeneration, Lewy Body Dementia, Lewy Body Dementia (LBD), Medical Research Council (MRC), Michael J Fox Foundation, Misfolded Proteins, Monument Trust Discovery Award (Parkinson's UK), MRC Brain Bank, National CJD Research and Surveillance Unit (NCJDRSU), National CJD Surveillance Unit: Western General Hospital: Data Release (HSCIC), National Institute for Health Research (NIHR), National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, NCJDRSU: National CJD Research and Surveillance Unit, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Nuffield Department of Clinical Neurosciences: University of Oxford, OPDC Discovery Cohort, OPTIMA Cohort, OPTIMA Cohort (Oxford Project to Investigate Memory and Ageing), Oxford Brain Bank, Oxford Parkinson's Disease Centre, Oxford Parkinson's Disease Centre (OPDC) Discovery Study, Oxford Parkinson's Disease Centre: University of Oxford, Preclinical Biomarkers and Dementia, Prion-Like Mechanisms, Real-Time Quaking-Induced Conversion (RT-QuIC) Based Assay, Scottish Government's Chief Scientists Office, Sporadic Creutzfeldt-Jakob Disease, Synucleinopathies, Synucleinopathy, Synucleinopathy Progression, UK Brain Banks Network, UK Parkinson’s Disease Society Brain Bank Clinical Diagnostic Criteria, Underlying Mechanisms of DLB Pathogenesis, University of Edinburgh, University of Oxford, Western General Hospital: Edinburgh | Leave a comment

Exploring Disease-Modifying Treatments for Lewy-Body Dementia (Frontiers in Neuroscience)

Posted on September 16, 2015 by Dementia and Elderly Care News

Summary The authors of this review remind readers that there are currently no disease-modifying therapies for Dementia with Lewy bodies (DLB). DLB accounts for perhaps 25% of all dementia cases. This review covers therapeutic directions which have been explored for … Continue reading →

Posted in Acute Hospitals, Community Care, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Models of Dementia Care, Quick Insights, Systematic Reviews | Tagged Abnormal Proteins (Alpha-Synuclein), Abnormal Proteins (Prions), Aging Mind and Brain Initiative: University of Iowa Iowa City, Basal Forebrain Cholinergic Neurons (BFCN), Behavioral and Psychological Symptoms of Dementia (BPSD), Behavioural and Psychological Symptoms of Dementia (BPSD), Brain Stimulation, Carver College of Medicine: University of Iowa Iowa City, DBS Targeting the Nucleus Basalis of Meynert (NBM), Deep Brain Stimulation, Deep Brain Stimulation (DBS), Deep Brain Stimulation (DBS) of Nucleus Basalis of Meynert (NBM) in Dementia with Lewy Bodies (DLB), Deep Brain Stimulation for the Treatment of Dementia, Dementia With Lewy Bodies (DLB), Department of Neurology: University of Iowa Iowa City, Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Disease-Modifying Treatments for Lewy-Body Dementia, DLB, DLB Management, DLB: Dementia with Lewy Bodies, Fibrils, Fluctuating Cognition, Fluctuations, Fornix DBS, Frontiers in Neuroscience, α-Synuclein, α-Synuclein Aggregation, α-Synuclein Misfolds, Lewy Body Degeneration, Lewy Body Dementia, Lewy Body Dementia (LBD), Misfolded Proteins, NBM DBS, Nerve Growth Factor (NGF) Secretion, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neurofibrillary Tangles, NFT+/Aβ- Brains (Neurofibrillary Tangles Without Amyloid [Aβ] Plaques), Non-Motor Fluctuations in Parkinson's Disease, Physician Scientist Training Program: University of Iowa Iowa City, Prion-Like Mechanisms, Synucleinopathy, Synucleinopathy Progression, Underlying Mechanisms of DLB Pathogenesis, United States, University of Iowa, USA | Leave a comment

Tag Archives: α-Synuclein Misfolds

Further Research Backs Speculation Linking the Immune System and Parkinson’s Disease (BBC News / Nature)

Early Diagnosis of Parkinson’s Disease and DLB Using CSF Biomarker? (BBC News / Annals of Clinical and Translational Neurology)

Exploring Disease-Modifying Treatments for Lewy-Body Dementia (Frontiers in Neuroscience)

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