Tag Archives: β-Amyloid 1-42 (Aβ42)

Repurposing of Existing Drugs to Prevent Dementia? (BBC News / Science Advances /Alzheimer’s Research UK)

Summary A number of drugs, already approved as safe for the treatment of other conditions, and which could help protect against Alzheimer’s Disease, are said to have been detected and short-listed for further investigation. Full Text Link Reference Alzheimer’s preventative … Continue reading

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Concerning the Diagnostic Accuracy of Plasma and CSF Biomarkers (Cochrane Database)

Summary This systematic review investigates the diagnostic accuracy of blood plasma and CSF Aß levels for detecting patients with mild cognitive impairment (MCI) and who are likely to progress to Alzheimer’s Disease or other types of dementia. The accuracy of … Continue reading

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Alzheimer’s Disease Biomarkers: Updated Hypothetical Model (Lancet Neurology)

Summary A hypothetical model of the major biomarkers of Alzheimer’s Disease, published by the same authors in 2010, has been updated in the light of new evidence. Full Text Link Reference Jack, CR. Jr. Knopman, DS. [and] Jagust, WJ. [et … Continue reading

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Metal Protein Attenuating Compounds for Alzheimer’s Disease (Cochrane Database)

Summary This systematic review evaluates the efficacy of metal protein attenuating compounds (MPACs) for the treatment of cognitive impairment in Alzheimer’s dementia. Earlier experimentation and mouse model studies had indicated that MPACs might promote the dissolution and clearance of beta-amyloid … Continue reading

Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Pharmacological Treatments, Systematic Reviews, UK | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Biomarker Assessments in Alzheimer’s Disease Clinical Trials (Quintiles / Frontiers in Aging Neuroscience)

Summary Accurate and sensitive tools are required for the early detection / diagnosis of Alzheimer’s Disease, particularly to assist research. Alzheimer’s Disease clinical trials make increasing use of biomarkers, particularly neuroimaging markers and cerebrospinal fluid (CSF) biomarkers obtained via invasive … Continue reading

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People Likely to Develop Alzheimer’s Disease are Potentially Identifiable Ten Years Earlier (Department of Health, Dementia)

[A version of this item appears in: Dementia: the Latest Evidence Newsletter (RWHT), Volume 2 Issue 7, February 2012]. Summary People at risk of developing Alzheimer’s Disease (AD) could be pre-diagnosed ten years before the disease becomes manifest, according to a … Continue reading

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