Tag Archives: β-amyloid

Alzheimer’s Disease: Solanezumab Drug Trial Flops (BBC News / Alzheimer’s and Dementia)

Summary The phase 3 EXPEDITION3 trial has been abandoned, as Solanezumab failed to slow cognitive decline in tests on around 2,000 patients with Alzheimer’s Disease. Several other amyloid-clearance drugs are going through trials apparently. Full Text Link Reference Walsh, F. … Continue reading

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New Hopes for Disease-Modifying Pharmacological Dementia Treatment (BBC News / AAIC / ARUK)

Summary Trials of the drug Solanezumab were abandoned in apparent failure in 2012. More detailed examination of the data has since revealed evidence that this medication may have a role in slowing the pace of progression in Alzheimer’s Disease slightly, … Continue reading

Posted in Alzheimer’s Research UK, BBC News, Charitable Bodies, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Models of Dementia Care, Patient Care Pathway, Pharmacological Treatments, Quick Insights, Statistics, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

More on the Cognitive Reserve Hypothesis (BBC News / Nature Neuroscience)

Summary A small study based at the University of California suggests some people’s brains may have the ability to resist early damage arising in the initial stages of Alzheimer’s Disease. In elderly subjects asked to memorise a series of pictures … Continue reading

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Concerning the Diagnostic Accuracy of Plasma and CSF Biomarkers (Cochrane Database)

Summary This systematic review investigates the diagnostic accuracy of blood plasma and CSF Aß levels for detecting patients with mild cognitive impairment (MCI) and who are likely to progress to Alzheimer’s Disease or other types of dementia. The accuracy of … Continue reading

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Use of Anti-Depressants to Slow Alzheimer’s Disease Onset? (BBC News / Science Translational Medicine / PNAS)

Summary Recent research into transgenic mice (and early, small-scale investigations with people) suggests that the anti-depressant citalopram could be used to slow the onset of Alzheimer’s Disease. This work in the United States appears to show that citalopram may counteract … Continue reading

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Alzheimer’s Disease Biomarkers: Updated Hypothetical Model (Lancet Neurology)

Summary A hypothetical model of the major biomarkers of Alzheimer’s Disease, published by the same authors in 2010, has been updated in the light of new evidence. Full Text Link Reference Jack, CR. Jr. Knopman, DS. [and] Jagust, WJ. [et … Continue reading

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Curcumin For Dementia? (ScientificWorldJournal)

Summary Curcumin is a polyphenolic compound which features in traditional Indian medicine. Earlier experimental and animal studies had indicated a protective effect of curcumin in Alzheimer’s Disease. This systematic review evaluates recent clinical trials into the use of curcumin for … Continue reading

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Metal Protein Attenuating Compounds for Alzheimer’s Disease (Cochrane Database)

Summary This systematic review evaluates the efficacy of metal protein attenuating compounds (MPACs) for the treatment of cognitive impairment in Alzheimer’s dementia. Earlier experimentation and mouse model studies had indicated that MPACs might promote the dissolution and clearance of beta-amyloid … Continue reading

Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Pharmacological Treatments, Systematic Reviews, UK | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Biomarker Assessments in Alzheimer’s Disease Clinical Trials (Quintiles / Frontiers in Aging Neuroscience)

Summary Accurate and sensitive tools are required for the early detection / diagnosis of Alzheimer’s Disease, particularly to assist research. Alzheimer’s Disease clinical trials make increasing use of biomarkers, particularly neuroimaging markers and cerebrospinal fluid (CSF) biomarkers obtained via invasive … Continue reading

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Dementia Risk From Cooked Meats? (BBC News / NHS Choices / PNAS)

Summary Research at the Icahn School of Medicine at Mount Sinai (New York), investigating the effect of Advanced Glycation End (AGEs) on mice and people, suggests that browning meat produces chemicals which may increase the risk of developing dementia. Mice … Continue reading

Posted in Animal Studies, BBC News, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment