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Tag Archives: β-Secretase 1 (BACE1)
Early Promising Signs in Verubecestat Human Drug Trial – Since Dashed (NHS Choices / Science Translational Medicine / Translational Neurodegeneration / Biospace Inc)
Summary Early results from a Phase I trial indicate that the BACE1 inhibitor Verubecestat may effectively reduce β-amyloid formation in human patients with Alzheimer’s Disease. This appears to confirm previous trials with rats, monkeys and healthy young human adults. As … Continue reading →
Posted in Animal Studies, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, Universal Interest
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Tagged Aducanumab, Aducanumab (Biogen), Aβ40, Aβ42, Amyloid, Amyloid Beta, Amyloid Hypothesis, Amyloid Precursor Protein (APP), Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Amyloidopathy, Anti-Amyloid Therapies, APECS Phase 3 Trial (ClinicalTrials.gov Identifier: NCT01953601), Aspartyl Proteases β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1 or β-Secretase), ß-amyloid, BACE1, BACE1 Inhibitors, Behind the Headlines, Beta-Amyloid, Beta-Amyloid Plaques, Biomarkers, Cerebrospinal Fluid (CSF), Cerebrospinal Fluid (CSF) Biomarkers, Cleveland Clinic Foundation, Department of Biostatistics: Merck Research Laboratories, Department of Clinical Research: Merck Research Laboratories, Department of Global Chemistry: Merck Research Laboratories, Department of Neuroscience: Merck Research Laboratories, Department of Pharmacokinetics Pharmacodynamics and Drug Metabolism: Merck Research Laboratories, Department of Safety Assessment: Merck Research Laboratories, Department of Translational Medicine: Merck Research Laboratories, EPOCH Phase 2/3 Trial (ClinicalTrials.gov Identifier: NCT01739348), β-Secretase 1 (BACE1), Lerner Research Institute, Merck Research Laboratories, PAREXEL (Glendale USA), Phase III APECS Study, sAPPβ, Science Translational Medicine, Translational Biomarkers Department: Merck Research Laboratories, Translational Neurodegeneration, United States, USA, Verubecestat, Verubecestat: Reduction of CSF Aβ and sAPPβ in Healthy Adults and AD Patients
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More on the Underlying Relationships Between Alzheimer’s Disease and Diabetes? (NHS Choices / Diabetologia)
Summary Further evidence has emerged concerning shared genetic linkages and biological processes underlying potential links between Alzheimer’s Disease and Type 2 Diabetes. Full Text Link Reference Diabetes drugs may be useful for Alzheimer’s, mice research finds. London: NHS Choices Behind … Continue reading →
Posted in Animal Studies, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Scotland, UK, Universal Interest
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Tagged Aberdeen, Alzheimer's Disease Pathogenesis, Alzheimer’s Disease and Diabetes, Amyloid Precursor Protein (APP), BACE1, Bace1 Deletion, Behind the Headlines, British Heart Foundation, Centre for Health Science: University of the Highlands and Islands, College of Life Sciences and Medicine: University of Aberdeen, Dementia and Diabetes, Department of Diabetes and Cardiovascular Science: University of the Highlands and Islands, Diabetes, Diabetes Mellitus, Diabetes UK, Diabetologia, Glucose Homeostasis, Glycogen, Increased Neuronal BACE1 Alters Systemic Glucose Metabolism, Institute of Medical Sciences: University of Aberdeen, β-Secretase 1 (BACE1), Leptin, Neuron-Specific Human BACE1 Knockin Mouse Model (PLB4), Neuronal BACE1 Regulates Metabolic Homeostasis, Romex Oilfield Chemicals, School of Medical Sciences: University of Aberdeen, Scottish Alzheimer's Research UK, Study of Diabetes (Lilly), Transgenic Mice, Type 2 Diabetes, Type 2 Diabetes and Alzheimer's Disease, University of Aberdeen, University of the Highlands and Islands (Inverness)
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