Tag Archives: Aβ-Plaques

Biogen’s Aducanumab: Possibly the First Viable Drug Treatment of Alzheimer’s Disease? (BBC News)

Summary There were early hopes that the drug Aducanumab (from Biogen) might be able to slow down the build-up of amyloid protein in the brain, but trials were halted in March 2019 due to “disappointing” trial results. Subsequent re-analysis of … Continue reading

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Transcranial Electromagnetic Treatment in Alzheimer’s Disease: Early Promising Results? (JAD / Bazian)

Summary Transcranial Electromagnetic Treatment (TEMT) for persons with mild / moderate Alzheimer’s Disease, delivered ia a bathing cap-style head device called the MemorEM, appears to bring about various statistically significant improvements without any observable adverse effects. Benefits are said to include: “ …cognitive enhancement, changes to CSF / … Continue reading

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Potential Relationship Between Vitamin A Deficiency and Alzheimer’s Disease Risk? (NHS Choices / Acta Neuropathologica)

Summary NHS Choices’ Behind the Headlines covers Chinese and Canadian research, based on both humans and animals, indicating potential associations between Vitamin A deficiency and later development of Alzheimer’s Disease. “ …vitamin A deficiency is a problem in the developing … Continue reading

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Early Signs of a Historic Breakthrough in the Treatment of Alzheimer’s Disease? (BBC News / Nature)

Summary Early results, based on small numbers of patients in a Phase I trial, indicate unprecedented progress in the development of a pharmacological treatment of Alzheimer’s Disease. The drug Aducanumab appears to combat (and reverse) the build-up of amyloid protein … Continue reading

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Patterns in the Development of Alzheimer’s Disease? (NHS Choices / Science Advances)

Summary Patterns of gene activity (gene expression) in specific areas of the brain may help explain why Alzheimer’s Disease tends to start in certain regions before spreading further through the brain. “ …those regions of the brain in which tissues … Continue reading

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EPPS Clears Amyloid Plaques in Mice: Alzheimer’s Disease Potentially Reversible? (BBC News / NHS Choices / Nature Communications)

Summary Korean researchers have identified a chemical (EPPS) which appears to be capable of clearing amyloid plaques from the brains of transgenic mice. The amount of plaques present in these animals’ brains was reduced in treated mice, and the treated … Continue reading

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Alzheimer’s Brain Plaques Cleared Rapidly by Cancer Drug in Mice (BBC News / NHS Choices)

Summary Clumps of a protein called beta-amyloid are a feature of Alzheimer’s Disease. The clearance of these plaques is widely thought to be a promising target for Alzheimer’s research. It has now been found that the destructive plaques found in the … Continue reading

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