Tag Archives: Abnormal Prion Protein

Possible Future Treatment of CJD? (BBC News)

Posted on October 10, 2018 by Dementia and Elderly Care News

Summary University College London Hospitals NHS Foundation Trust (UCLH)’s National Prion Clinic has been granted the go-ahead to test the use of a man-made antibody treatment (PRN100), with a view to halting or slowing the progression of sporadic CJD. “We … Continue reading →

Grounds for Cautious Optimism Regarding Two Drugs Re-Purposed for Neurodegenerative Diseases? (BBC News / MRC / NHS Choices / Brain)

Posted on April 20, 2017 by Dementia and Elderly Care News

Summary Animal research, involving mice, has indicated promising results for the potential of two re-purposed drugs in helping to slow or halt the progression of a number of neurodegenerative brain diseases, including dementia. “The best known drug of the pair … Continue reading →

Posted in Animal Studies, BBC News, For Researchers (mostly), In the News, National, NHS Digital (Previously NHS Choices), Parkinson's Disease, Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged Abnormal Prion Protein, Alzheimer's Disease, Alzheimer's Research UK, Alzheimer’s Drug Discovery Foundation, Alzheimer’s Research UK (ARUK), Alzheimer’s Research UK Drug Discovery Institute, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Autoimmune Attacks, Autoimmune Cell Defences, BBC Health News, Behind the Headlines, Brain (Journal), Centre for Analytical Bioscience: University of Nottingham, CJD, Creutzfeldt-Jakob Disease, Creuzfeldt Jacob Disease (CJD), Department of Clinical Neurosciences: University of Cambridge, Dibenzoylmethane, Dibenzoylmethane (DBM): Potential Anti-Cancer Drug, Disease-Modifying Therapies, Disease-Modifying Therapies for Dementia, Dr David Dexter: Parkinson's UK, Dr Doug Brown: Director of Research and Development at Alzheimer's Society, Drug Discovery Programmes, eIF2a-P-Mediated Translational Repression (Pathway of Neurodegeneration), Frontotemporal Dementia (FTD), Huntingtin Protein, Huntington’s Disease, α-Synuclein, α-Synuclein Aggregation, Lentivirally Mediated RNA Interference (RNAi), Medical Research Council (MRC), Medical Research Council (UK), Medical Research Council Toxicology Unit: University of Leicester, Medical Research Council’s (MRC) Toxicology Unit, Microscopic Worms, Misfolded Prion Protein (PrP), Misfolded Proteins, Motor Neurone Disease (MND), MRC Toxicology Unit: University of Leicester, MRC: Medical Research Council, Multiple Sclerosis, National Institute for Neurological Disorders and Stroke, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuronal Loss, Neuroprotection, Parkinson's, Potential Repurposing of Drugs to Slow Progression of Alzheimer’s Disease, Prion Diseases, Prion Protein (PrP(C)), Prion-Infected Mice, Prof. Giovanna Mallucci, Professor Giovanna Mallucci: Associate Drector of UK Dementia Research Institute, Protein Misfolding, Rare Prion Diseases, Repurposing of Drugs, Synucleinopathy, Tau, Tau Protein, Tauopathy, Translational Research, Transmissible Spongiform Encephalopathies, Trazodone, Trazodone Hydrochloride (Antidepressant), UK Dementia Research Institute, UK Dementia Research Institute (UK DRI), Unfolded Protein Response (UPR), University of Cambridge, University of Leicester, University of Nottingham, Worms: C. elegans | Leave a comment

Urine Test for Creutzfeldt-Jakob Disease (CJD)? (BBC News / MRC / JAMA Neurology / NEJM)

Posted on October 4, 2016 by Dementia and Elderly Care News

Summary It may one day be possible to use a non-invasive diagnostic urine test to discover whether or not patients have sporadic Creutzfeldt-Jakob Disease (sCJD). Full Text Link Reference A urine test for Creutzfeldt-Jakob Disease may be possible. London: Medical … Continue reading →

Alzheimer’s Disease Contractable Via Brain Surgery? (NHS Choices / Swiss Medical Weekly)

Posted on February 22, 2016 by Dementia and Elderly Care News

Summary Further evidence points to a theoretical risk of Alzheimer’s Disease being potentially transmissible during surgical procedures, in the manner of Creutzfeldt-Jakob disease (CJD). Full Text Link Reference New clues that Alzheimer’s may have been spread during surgery. London: NHS … Continue reading →

Posted in Acute Hospitals, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest | Tagged Abnormal Prion Protein, Aβ Deposition in Grey Matter, Aβ in Blood Vessel Walls, Aβ Seeds, Aβ Seeds: Transmitted Iatrogenically with iCJD, Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis, Alzheimer-Type Neuropathology in Iatrogenic Creutzfeldt-Jakob Disease After Dural Grafting, Alzheimer’s Disease Contracted Via Brain Surgery, Alzheimer’s Disease Transmission (Hypothesis), Amyloid, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β Protein, Austria, Behind the Headlines, Brain Parenchymal Aβ Plaques, Cleaning and Decontamination, Congophilic Amyloid Angiopathy, Contaminated Surgical Instruments, Decontamination of Surgical Instruments, Dural Grafting, Human Transmission of Aβ, Human Transmission of Amyloid-β Pathology, Human-Derived Growth Hormones, Iatrogenic CJD, Iatrogenic Creutzfeldt-Jakob Disease, Iatrogenic Creutzfeldt-Jakob Disease After Dural Grafting, Iatrogenic Routes of Prion Transmission Generalisable to Aβ (Hypothesis), Iatrogenic Routes of Prion Transmission Generalisable to Proteopathic Seeds of Neurodegenerative Disease (Hypothesis), Induction of Cerebral β-Amyloidosis: Intracerebral Versus Systemic Aβ Inoculation, Institute of Neurology: Medical University Vienna, Institute of Neuropathology: University Hospital Zurich, Medical University Vienna, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroepidemiology, Prion Diseases, Protein Seeds (Amyloid), Protein Seeds of Alzheimer’s Disease (Hypothesis), Proteopathic Seeds of Neurodegenerative Disease, Risk Factors and Preventive Interventions for Alzheimer Disease, Risk of Prion-Like Disease Transmission by Alzheimer- or Parkinson-Associated Protein Particles, Surgical Transmission of Prions, Swiss Medical Weekly, Switzerland, Transmissible Alzheimer's Disease (Theoretical Risk), Transmissible Spongiform Encephalopathy Agents: General Principles of Decontamination and Waste Disposal, University Hospital Zurich | Leave a comment

Potential Risk of Alzheimer’s Disease Transmission (BBC News / NHS Choices / Nature / MRC)

Posted on September 10, 2015 by Dementia and Elderly Care News

Summary There may be a theoretical risk of Alzheimer’s Disease being transmissible during surgical procedures, in the manner of Creutzfeldt-Jakob disease (CJD). This hypothesis has arisen as a result of the examination of the brains of eight patients who had … Continue reading →

Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Quick Insights, UK, Universal Interest | Tagged Abnormal Prion Protein, Aβ Deposition in Grey Matter, Aβ in Blood Vessel Walls, Aβ Seeds, Aβ Seeds: Transmitted Iatrogenically with iCJD, Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis, Alzheimer-Type Neuropathology in Iatrogenic Creutzfeldt-Jakob Disease After Dural Grafting, Alzheimer’s Disease and Blood Transfusion, Alzheimer’s Disease Transmission (Hypothesis), Amyloid, Amyloid Beta Protein, Amyloid Proteins, Amyloid-Beta Deposition in APP Transgenic Mice, Amyloid-β (Aβ), Amyloid-β Protein, BBC Health News, Behind the Headlines, Brain Deposition of Amyloid, Brain-Derived Human Growth Hormone (HGH), Cadaver-Derived Growth Hormone, Cerebral Amyloid Angiopathy, Coexistence of Alzheimer-Type Neuropathology in Creutzfeldt-Jakob Disease, Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), Contaminated Surgical Instruments, Contamination of Injections, Creutzfeldt Jacob Disease (CJD), Creutzfeldt-Jakob Disease (CJD), Creutzfeldt-Jakob Disease in United Kingdom Patients Treated With Human Pituitary Growth Hormone, Decontamination of Surgical Instruments, Department of Neurodegenerative Disease: UCL Institute of Neurology, Exogenous Induction of Cerebral β-Amyloidogenesis, Grey Matter and Vascular Amyloid-β (Aβ) Pathology, Human Pituitary-Derived Growth Hormone, Human Transmission of Amyloid-β Pathology, Human-Derived Growth Hormones, Iatrogenic CJD, Iatrogenic Creutzfeldt-Jakob Disease, Iatrogenic Routes of Prion Transmission Generalisable to Aβ (Hypothesis), Iatrogenic Routes of Prion Transmission Generalisable to Proteopathic Seeds of Neurodegenerative Disease (Hypothesis), Induction of Cerebral β-Amyloidosis: Intracerebral Versus Systemic Aβ Inoculation, Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract, Medical Research Council, Medical Research Council (MRC), Medical Research Council Prion Unit, Misfolded Proteins, MRC Clinical Trials Unit at University College London, National Institute of Health Research (NIHR), National Prion Clinic: National Hospital for Neurology and Neurosurgery, National Prion Monitoring Cohort Study, Nature, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroepidemiology, Neuropathologic Assessment of Alzheimer’s Disease, NHS National Prion Clinic (NPC) in London, Peripheral Administration of Tau Aggregates Triggers Intracerebral Tauopathy in Transgenic Mice, Potential Infectivity of Alzheimer and Parkinson Disease Proteins in Recipients of Cadaver-Derived Human Growth Hormone, Prion Diseases, Protein Seeds (Amyloid), Protein Seeds of Alzheimer’s Disease (Hypothesis), Proteopathic Seeds of Neurodegenerative Disease, Risk Factors and Preventive Interventions for Alzheimer Disease, Risk of Prion-Like Disease Transmission by Alzheimer- or Parkinson-Associated Protein Particles, Seeded β-Amyloid in APP Transgenic Mice, Surgical Transmission of Prions, Transmissible Alzheimer's Disease (Theoretical Risk), Transmissible and Non-Transmissible Amyloidoses, UCLH / UCL Biomedical Research Centre, UCLH / UCL Dementia Biomedical Research Unit, University College London (UCL) | Leave a comment

Evolutionary Mutation of Human Prion Protein May Prevent Prion Diseases? (NHS Choices / BBC News / Nature)

Posted on June 20, 2015 by Dementia and Elderly Care News

Summary A natural human mutation (called V127) in the gene encoding prion protein may offer resistance to CJD. A study using mice with this genetic mutation appears to confirm resistance to prion diseases. This finding may in future help in … Continue reading →

Posted in Animal Studies, BBC News, For Doctors (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest | Tagged Abnormal Prion Protein, Abnormal Proteins (Prions), BBC Health News, Behind the Headlines, Bovine Spongiform Encephalopathy (BSE), Brain-Eating Cannibals (Mortuary Feasts), CJD, Colorado State University, Creutzfeldt Jacob Disease (CJD), Creutzfeldt-Jakob Disease (CJD), Department of Neurodegenerative Disease: UCL Institute of Neurology, Evolved Protection Against Human Prions, Familial or Inherited CJD, Fore People (Tribe in Papua New Guinea), Kuru, M129V, Mad Cow Disease, Medical Research Council (MRC), Mice With Prion Disease Similar to Cruetzfeldt-Jakob Disease (CJD), Misfolded Prion Protein (PrP), Misfolded Proteins, MRC Prion Unit, MRC Prion Unit: UCL Institute of Neurology, Nature, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuroprotection, Neuroprotection Research, Papua New Guinea, Papua New Guinea Institute of Medical Research, Prion Diseases, Prion Protein, Prion Protein (PrP) Variant G127V, Prion Protein Gene, Prion Research Center: Colorado State University, Prion-Infected Mice, Prof John Collinge: Medical Research Council's Prion Unit at University College London, Protective Prion Protein Variant, Sporadic CJD, Transgenic Mice, UCL Institute of Neurology, United States, University College London (UCL), USA, V127 Gene: Resistance to Prion Diseases, Variant CJD, vCJD Infection | Leave a comment

Lancet Seminar on Parkinson’s Disease (Lancet / Advances in Integrative Medicine / Translational Proteomics / Parkinson’s UK / BBC News)

Posted on April 22, 2015 by Dementia and Elderly Care News

Summary Coinciding with Parkinson’s Awareness Week 2015 (April 20th – 26th 2015), the following Lancet review / seminar covers the clinical features, risk factors, pathology, genetics, pathogenesis, diagnosis and treatment of Parkinson’s Disease. Full Text Link (Note: This article requires … Continue reading →

Tag Archives: Abnormal Prion Protein

Possible Future Treatment of CJD? (BBC News)

Grounds for Cautious Optimism Regarding Two Drugs Re-Purposed for Neurodegenerative Diseases? (BBC News / MRC / NHS Choices / Brain)

Alzheimer’s Disease Contractable Via Brain Surgery? (NHS Choices / Swiss Medical Weekly)

Potential Risk of Alzheimer’s Disease Transmission (BBC News / NHS Choices / Nature / MRC)

Evolutionary Mutation of Human Prion Protein May Prevent Prion Diseases? (NHS Choices / BBC News / Nature)

Lancet Seminar on Parkinson’s Disease (Lancet / Advances in Integrative Medicine / Translational Proteomics / Parkinson’s UK / BBC News)

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