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Tag Archives: Abnormal Prion Protein
Possible Future Treatment of CJD? (BBC News)
Summary University College London Hospitals NHS Foundation Trust (UCLH)’s National Prion Clinic has been granted the go-ahead to test the use of a man-made antibody treatment (PRN100), with a view to halting or slowing the progression of sporadic CJD. “We … Continue reading
Posted in Acute Hospitals, BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, Management of Condition, Pharmacological Treatments, Quick Insights, Universal Interest
Tagged Abnormal Prion Protein, Abnormal Proteins (Prions), BBC Health News, Creutzfeldt-Jakob Disease, Creutzfeldt-Jakob Disease (CJD), Medical Research Council Prion Unit, Misfolded Prion Protein (PrP), MRC Prion Unit, National Care Team (CJD), National Hospital for Neurology and Neurosurgery: University College London Hospitals NHS Foundation Trust, National Prion Clinic, National Prion Clinic: University College London Hospitals NHS Foundation Trust, Neurodegenerative Disease Research, Neurodegenerative Diseases, NHS National Prion Clinic (NPC) in London, Prion Diseases, Prion Protein, PRN100, Rare Prion Diseases, Sporadic CJD, sporadic Creutzfeldt-Jakob Disease (sCJD), UCLH: University College London Hospitals NHS Foundation Trust, University College London Hospitals NHS Foundation Trust, University College London Hospitals NHS Foundation Trust (UCLH): National Prion Clinic
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Alzheimer’s Disease Contractable Via Brain Surgery? (NHS Choices / Swiss Medical Weekly)
Summary Further evidence points to a theoretical risk of Alzheimer’s Disease being potentially transmissible during surgical procedures, in the manner of Creutzfeldt-Jakob disease (CJD). Full Text Link Reference New clues that Alzheimer’s may have been spread during surgery. London: NHS … Continue reading
Posted in Acute Hospitals, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest
Tagged Abnormal Prion Protein, Aβ Deposition in Grey Matter, Aβ in Blood Vessel Walls, Aβ Seeds, Aβ Seeds: Transmitted Iatrogenically with iCJD, Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis, Alzheimer-Type Neuropathology in Iatrogenic Creutzfeldt-Jakob Disease After Dural Grafting, Alzheimer’s Disease Contracted Via Brain Surgery, Alzheimer’s Disease Transmission (Hypothesis), Amyloid, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β Protein, Austria, Behind the Headlines, Brain Parenchymal Aβ Plaques, Cleaning and Decontamination, Congophilic Amyloid Angiopathy, Contaminated Surgical Instruments, Decontamination of Surgical Instruments, Dural Grafting, Human Transmission of Aβ, Human Transmission of Amyloid-β Pathology, Human-Derived Growth Hormones, Iatrogenic CJD, Iatrogenic Creutzfeldt-Jakob Disease, Iatrogenic Creutzfeldt-Jakob Disease After Dural Grafting, Iatrogenic Routes of Prion Transmission Generalisable to Aβ (Hypothesis), Iatrogenic Routes of Prion Transmission Generalisable to Proteopathic Seeds of Neurodegenerative Disease (Hypothesis), Induction of Cerebral β-Amyloidosis: Intracerebral Versus Systemic Aβ Inoculation, Institute of Neurology: Medical University Vienna, Institute of Neuropathology: University Hospital Zurich, Medical University Vienna, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroepidemiology, Prion Diseases, Protein Seeds (Amyloid), Protein Seeds of Alzheimer’s Disease (Hypothesis), Proteopathic Seeds of Neurodegenerative Disease, Risk Factors and Preventive Interventions for Alzheimer Disease, Risk of Prion-Like Disease Transmission by Alzheimer- or Parkinson-Associated Protein Particles, Surgical Transmission of Prions, Swiss Medical Weekly, Switzerland, Transmissible Alzheimer's Disease (Theoretical Risk), Transmissible Spongiform Encephalopathy Agents: General Principles of Decontamination and Waste Disposal, University Hospital Zurich
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Potential Risk of Alzheimer’s Disease Transmission (BBC News / NHS Choices / Nature / MRC)
Summary There may be a theoretical risk of Alzheimer’s Disease being transmissible during surgical procedures, in the manner of Creutzfeldt-Jakob disease (CJD). This hypothesis has arisen as a result of the examination of the brains of eight patients who had … Continue reading
Posted in BBC News, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Quick Insights, UK, Universal Interest
Tagged Abnormal Prion Protein, Aβ Deposition in Grey Matter, Aβ in Blood Vessel Walls, Aβ Seeds, Aβ Seeds: Transmitted Iatrogenically with iCJD, Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis, Alzheimer-Type Neuropathology in Iatrogenic Creutzfeldt-Jakob Disease After Dural Grafting, Alzheimer’s Disease and Blood Transfusion, Alzheimer’s Disease Transmission (Hypothesis), Amyloid, Amyloid Beta Protein, Amyloid Proteins, Amyloid-Beta Deposition in APP Transgenic Mice, Amyloid-β (Aβ), Amyloid-β Protein, BBC Health News, Behind the Headlines, Brain Deposition of Amyloid, Brain-Derived Human Growth Hormone (HGH), Cadaver-Derived Growth Hormone, Cerebral Amyloid Angiopathy, Coexistence of Alzheimer-Type Neuropathology in Creutzfeldt-Jakob Disease, Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), Contaminated Surgical Instruments, Contamination of Injections, Creutzfeldt Jacob Disease (CJD), Creutzfeldt-Jakob Disease (CJD), Creutzfeldt-Jakob Disease in United Kingdom Patients Treated With Human Pituitary Growth Hormone, Decontamination of Surgical Instruments, Department of Neurodegenerative Disease: UCL Institute of Neurology, Exogenous Induction of Cerebral β-Amyloidogenesis, Grey Matter and Vascular Amyloid-β (Aβ) Pathology, Human Pituitary-Derived Growth Hormone, Human Transmission of Amyloid-β Pathology, Human-Derived Growth Hormones, Iatrogenic CJD, Iatrogenic Creutzfeldt-Jakob Disease, Iatrogenic Routes of Prion Transmission Generalisable to Aβ (Hypothesis), Iatrogenic Routes of Prion Transmission Generalisable to Proteopathic Seeds of Neurodegenerative Disease (Hypothesis), Induction of Cerebral β-Amyloidosis: Intracerebral Versus Systemic Aβ Inoculation, Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract, Medical Research Council, Medical Research Council (MRC), Medical Research Council Prion Unit, Misfolded Proteins, MRC Clinical Trials Unit at University College London, National Institute of Health Research (NIHR), National Prion Clinic: National Hospital for Neurology and Neurosurgery, National Prion Monitoring Cohort Study, Nature, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Disorders, Neuroepidemiology, Neuropathologic Assessment of Alzheimer’s Disease, NHS National Prion Clinic (NPC) in London, Peripheral Administration of Tau Aggregates Triggers Intracerebral Tauopathy in Transgenic Mice, Potential Infectivity of Alzheimer and Parkinson Disease Proteins in Recipients of Cadaver-Derived Human Growth Hormone, Prion Diseases, Protein Seeds (Amyloid), Protein Seeds of Alzheimer’s Disease (Hypothesis), Proteopathic Seeds of Neurodegenerative Disease, Risk Factors and Preventive Interventions for Alzheimer Disease, Risk of Prion-Like Disease Transmission by Alzheimer- or Parkinson-Associated Protein Particles, Seeded β-Amyloid in APP Transgenic Mice, Surgical Transmission of Prions, Transmissible Alzheimer's Disease (Theoretical Risk), Transmissible and Non-Transmissible Amyloidoses, UCLH / UCL Biomedical Research Centre, UCLH / UCL Dementia Biomedical Research Unit, University College London (UCL)
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Evolutionary Mutation of Human Prion Protein May Prevent Prion Diseases? (NHS Choices / BBC News / Nature)
Summary A natural human mutation (called V127) in the gene encoding prion protein may offer resistance to CJD. A study using mice with this genetic mutation appears to confirm resistance to prion diseases. This finding may in future help in … Continue reading
Posted in Animal Studies, BBC News, For Doctors (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest
Tagged Abnormal Prion Protein, Abnormal Proteins (Prions), BBC Health News, Behind the Headlines, Bovine Spongiform Encephalopathy (BSE), Brain-Eating Cannibals (Mortuary Feasts), CJD, Colorado State University, Creutzfeldt Jacob Disease (CJD), Creutzfeldt-Jakob Disease (CJD), Department of Neurodegenerative Disease: UCL Institute of Neurology, Evolved Protection Against Human Prions, Familial or Inherited CJD, Fore People (Tribe in Papua New Guinea), Kuru, M129V, Mad Cow Disease, Medical Research Council (MRC), Mice With Prion Disease Similar to Cruetzfeldt-Jakob Disease (CJD), Misfolded Prion Protein (PrP), Misfolded Proteins, MRC Prion Unit, MRC Prion Unit: UCL Institute of Neurology, Nature, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuroprotection, Neuroprotection Research, Papua New Guinea, Papua New Guinea Institute of Medical Research, Prion Diseases, Prion Protein, Prion Protein (PrP) Variant G127V, Prion Protein Gene, Prion Research Center: Colorado State University, Prion-Infected Mice, Prof John Collinge: Medical Research Council's Prion Unit at University College London, Protective Prion Protein Variant, Sporadic CJD, Transgenic Mice, UCL Institute of Neurology, United States, University College London (UCL), USA, V127 Gene: Resistance to Prion Diseases, Variant CJD, vCJD Infection
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Lancet Seminar on Parkinson’s Disease (Lancet / Advances in Integrative Medicine / Translational Proteomics / Parkinson’s UK / BBC News)
Summary Coinciding with Parkinson’s Awareness Week 2015 (April 20th – 26th 2015), the following Lancet review / seminar covers the clinical features, risk factors, pathology, genetics, pathogenesis, diagnosis and treatment of Parkinson’s Disease. Full Text Link (Note: This article requires … Continue reading
Posted in Acute Hospitals, BBC News, Charitable Bodies, Community Care, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Management of Condition, Non-Pharmacological Treatments, Parkinson's Disease, Pharmacological Treatments, Quick Insights, Scotland, Systematic Reviews, UK, Universal Interest
Tagged Abnormal Prion Protein, Abnormal Proteins (Alpha-Synuclein), Abnormal Proteins (Prions), Acting Out Dreams: Rapid Eye Movement (REM) Sleep Behaviour Disorder, Advances in Integrative Medicine, Association of RBD with Synucleinopathies, BBC Health News, Biomarkers, Braak Model, Braak Staging of Lewy Pathology in Parkinson’s Disease, Canada, CHCHD2, CIND-PD: Cognitive Impairment in Parkinson's Disease, Clinical Symptoms and Time Course of Parkinson’s Disease Progression, Complications of Dopaminergic Therapies for Parkinson’s Disease, Deep Brain Stimulation (DBS), Dementia in Parkinson's Disease, Department of Human Protein Sciences: Geneva University Hospitals, Department of Neurology: Geneva University Hospitals, DNAJC13, Dopamine, Dopamine Replacement Therapy (DRT), Dreaming in Dementia: REM Sleep Behaviour Disorder and Synucleinopathy, Drug Treatments for Parkinson’s Disease, Early Parkinson Disease, Edmond J Safra Program in Parkinson’s Disease: Toronto Western Hospital, EIF4G1, Faculty of Medicine: Geneva University Hospitals, Falls in Parkinson's Disease, Genetics of Parkinson's Disease, Geneva University Hospitals, Institute of Neurological Sciences in Glasgow, α-Synuclein, α-Synuclein Aggregation, Lancet, Lewy Body Parkinson Disease, LRRK2, LRRK2: Leucine-Rich Repeat Kinase 2 Gene, Monogenic Forms of Parkinson’s Disease (By Gene), Morton and Gloria Shulman Movement Disorders Clinic: Toronto Western Hospital, National Deep Brain Stimulation Service for Scotland, National Service in Scotland: NHS DBS Centres in Scotland, National Specialist Services Committee (Scotland), Neuroproteomics Group: Geneva University Hospitals, NHS DBS Centres in England, Non-Motor Fluctuations in Parkinson's Disease, Parkin (PARK2), Parkinson's Awareness Week, Parkinson’s Awareness Week (2015), Parkinson’s Disease Awareness Week (2015), Parkinson’s Disease Dementia, Parkinson’s Disease Diagnosis, Parkinson’s Disease Pathogenesis, Parkinson’s UK, Parkinson’s UK (Parkinsons Disease Society), Parkinson’s-Like Symptoms, Parkinsonian Symptoms, Parkinsonism, PDD: Parkinson's Disease with Dementia, Prion Diseases, Prion Protein, Proteomic Profiling of Parkinson's Disease-Relevant Brain Regions, Proteomics, Rapid Eye Movement (REM) Sleep Behaviour Disorder, Rapid Eye Movement (REM) Sleep Disorder, Rapid Eye Movement Sleep Behaviour Disorder (RBD), RBD: Rapid Eye Movement Sleep Behaviour Disorder, SNCA, SNCA: α-Synuclein Gene, Switzerland, Synucleinopathies, Synucleinopathy, Toronto Western Hospital, Translational Proteomics, UK Parkinson’s Disease Society Brain Bank Clinical Diagnostic Criteria, University Medical Center: Geneva University Hospitals, University of Toronto, VPS35
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Giant Steps: Re-Tracing the Development of a Promising Research Approach
Summary Following the announcement earlier this week of a probable (if still early-stage) historic breakthrough in finding a potential approach to preventing neurodegeneration across Alzheimer’s, Parkinson’s and Huntington’s Diseases, readers may be interested in viewing the publication history of research … Continue reading
Posted in For Doctors (mostly), For Researchers (mostly), In the News, International, NIHR, Parkinson's Disease, Quick Insights, UK
Tagged Abnormal Prion Protein, Alzheimer's Disease, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Autoimmune Attacks, Autoimmune Cell Defences, Bovine Spongiform Encephalopathy (BSE), Centre for Neuroscience Research and Centre for Integrative Physiology: University of Edinburgh, Centre for Neuroscience Research: University of Edinburgh, CJD, Creutzfeldt-Jakob Disease, Creuzfeldt Jacob Disease (CJD), Department of Neurodegenerative Disease: University College London, eIF2α-P Dephosphorylation, eIF2α-P Levels, Eukaryotic Translation Initiation Factor (eIF2), GADD34, GlaxoSmithKline, Hodgkin Building, Huntingtin Protein, Huntington’s Disease, Institut National de la Recherche Agronomique, α-Synuclein, α-Synuclein Aggregation, Lentivirally Mediated RNA Interference (RNAi), Medical Research Council (MRC), Medical Research Council (UK), Medical Research Council Toxicology Unit: University of Leicester, Medical Research Council: University College London, Misfolded Prion Protein (PrP), Misfolded Proteins, Motor Neurone Disease (MND), MRC Toxicology Unit: University of Leicester, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuronal Loss, Neuroprotection, Neurotoxic Effect of Scrapie Prions, Neurotoxicity, Partially-Protease Resistant Isoform (PrP(Sc)), PERK (Protein Kinase RNA–Like Endoplasmic Reticulum Kinase), Prion Diseases, Prion Protein (PrP(C)), Prion Unit Institute of Neurology: University College London, Prion-Infected Mice, Prof. Giovanna Mallucci, Protein Misfolding, Rare Prion Diseases, Science Translational Medicine, Scrapie, Spongiosis and Neuronal Loss, Synaptic Dysfunction, Synaptic Failure, Synucleinopathy, Tau, Tau Protein, Tauopathy, Translational Research, Transmissible Spongiform Encephalopathies, Transmissible Spongiform Encephalopathies (TSEs), Unfolded Protein Response (UPR), University College London, University of Edinburgh, University of Leicester, University of Nottingham, UPR Activation, Virologie Immunologie Moléculaires
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Breakthrough Discovery of Chemical to Prevent Neurodegeneration Across Alzheimer’s, Parkinson’s and Huntington’s Diseases (BBC News / NHS Choices / Science Translational Medicine)
Summary A chemical substance has been identified which shows signs of being able to halt a range of neurodegenerative diseases in mice. This may well be a historic event in research, although more research is required; the development of drug treatments … Continue reading
Posted in Animal Studies, BBC News, For Carers (mostly), For Doctors (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Parkinson's Disease, Quick Insights, UK, Universal Interest
Tagged Abnormal Prion Protein, Alzheimer's Disease, Amyloid Beta, Amyloid Beta Protein, Amyloid Proteins, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Autoimmune Attacks, Autoimmune Cell Defences, Bazian, BBC Health News, Behind the Headlines, Bovine Spongiform Encephalopathy (BSE), CJD, Creutzfeldt-Jakob Disease, Creuzfeldt Jacob Disease (CJD), eIF2α-P Dephosphorylation, eIF2α-P Levels, Eukaryotic Translation Initiation Factor (eIF2), GADD34, GlaxoSmithKline, Huntingtin Protein, Huntington’s Disease, α-Synuclein, α-Synuclein Aggregation, Medical Research Council (MRC), Medical Research Council (UK), Medical Research Council Toxicology Unit: University of Leicester, Misfolded Prion Protein (PrP), Misfolded Proteins, Motor Neurone Disease (MND), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuronal Loss, Neuroprotection, PERK (Protein Kinase RNA–Like Endoplasmic Reticulum Kinase), Prion Diseases, Prion-Infected Mice, Prof. Giovanna Mallucci, Protein Misfolding, Science Translational Medicine, Scrapie, Synaptic Failure, Synucleinopathy, Tau, Tau Protein, Tauopathy, Translational Research, Transmissible Spongiform Encephalopathies (TSEs), Unfolded Protein Response (UPR), University of Leicester, University of Nottingham
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