Tag Archives: Abnormal Proteins (Prions)

Possible Future Treatment of CJD? (BBC News)

Summary University College London Hospitals NHS Foundation Trust (UCLH)’s National Prion Clinic has been granted the go-ahead to test the use of a man-made antibody treatment (PRN100), with a view to halting or slowing the progression of sporadic CJD. “We … Continue reading

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Structure of Tau Filaments in Alzheimer’s Disease Discovered (MRC / BBC News / Nature / NHS Choices)

Summary Research at the MRC Laboratory of Molecular Biology has taken advantage of a “resolution revolution” in microscopy to uncover the atomic structure of Tau filaments (one of the two types of the abnormal tangles associated with Alzheimer’s Disease). “Tau forms … Continue reading

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Urine Test for Creutzfeldt-Jakob Disease (CJD)? (BBC News / MRC / JAMA Neurology / NEJM)

Summary It may one day be possible to use a non-invasive diagnostic urine test to discover whether or not patients have sporadic Creutzfeldt-Jakob Disease (sCJD). Full Text Link Reference A urine test for Creutzfeldt-Jakob Disease may be possible. London: Medical … Continue reading

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Exploring Disease-Modifying Treatments for Lewy-Body Dementia (Frontiers in Neuroscience)

Summary The authors of this review remind readers that there are currently no disease-modifying therapies for Dementia with Lewy bodies (DLB). DLB accounts for perhaps 25% of all dementia cases. This review covers therapeutic directions which have been explored for … Continue reading

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Minimising CJD and vCJD Transmission Risks in Healthcare and Community Settings (Department of Health)

Summary The Advisory Committee on Dangerous Pathogens’ Transmissible Spongiform Encephalopathy (ACDP TSE) Risk Management Subgroup has released updated guidance which aims to minimise the risks of transmission of CJD and vCJD in healthcare and other public settings. Full Text Link … Continue reading

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Evolutionary Mutation of Human Prion Protein May Prevent Prion Diseases? (NHS Choices / BBC News / Nature)

Summary A natural human mutation (called V127) in the gene encoding prion protein may offer resistance to CJD. A study using mice with this genetic mutation appears to confirm resistance to prion diseases. This finding may in future help in … Continue reading

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Lancet Seminar on Parkinson’s Disease (Lancet / Advances in Integrative Medicine / Translational Proteomics / Parkinson’s UK / BBC News)

Summary Coinciding with Parkinson’s Awareness Week 2015 (April 20th – 26th 2015), the following Lancet review / seminar covers the clinical features, risk factors, pathology, genetics, pathogenesis, diagnosis and treatment of Parkinson’s Disease. Full Text Link (Note: This article requires … Continue reading

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Risks of Variant Creutzfeldt-Jakob Disease: UK Blood Safety (Department of Health)

Summary This document presents the Government’s response to the Science and Technology Select Committee’s “After the Storm?” report on blood safety. It sets out the government’s commitment to evidence-based and cost effective ways to reduce risks of infection from blood transfusions, … Continue reading

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Potential Transmission of vCJD (BBC News / House of Commons Science and Technology Committee / SaBTO)

Summary The House of Commons Science and Technology Committee has asserted that the government has a too casual approach to the human form of mad cow disease. Roughly one in 2,000 people in the UK could be a carrier of … Continue reading

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Blood Donation and Transmission of vCJD: Inquiry Required? (BBC News)

Summary The Commons Science and Technology Committee has called for an independent inquiry to check the safety of donor blood arising from the hidden risk of infection from variant CJD (the human form of “mad cow disease”). A recent study revealed one in 2,000 Britons … Continue reading

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