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Tag Archives: Abnormal Proteins (Tau)
Structure of Tau Filaments in Alzheimer’s Disease Discovered (MRC / BBC News / Nature / NHS Choices)
Summary Research at the MRC Laboratory of Molecular Biology has taken advantage of a “resolution revolution” in microscopy to uncover the atomic structure of Tau filaments (one of the two types of the abnormal tangles associated with Alzheimer’s Disease). “Tau forms … Continue reading
Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, National, NHS Digital (Previously NHS Choices), Pharmacological Treatments, Quick Insights, UK, Universal Interest
Tagged Abnormal Proteins, Abnormal Proteins (Alpha-Synuclein), Abnormal Proteins (Prions), Abnormal Proteins (Tau), Alzheimer’s Disease, Amyloid and Tau Imaging, Atomic Structure of Tau Filaments, BBC Health News, Behind the Headlines, Cryo-Electron Microscopy (Cryo-EM), Cryo-EM Structures of PHFs and SFs, Cryo-EM Structures of Tau Filaments, Department of Pathology and Laboratory Medicine: Indiana University School of Medicine, Drug Trials Failure Rate, European Union, Indiana University, Indiana University School of Medicine, Laboratory of Molecular Biology (LMB) Neuroscience Division, Medical Research Council (MRC), Misfolded Proteins, MRC Laboratory of Molecular Biology, MRC Laboratory of Molecular Biology (LMB), MRC Laboratory of Molecular Biology: Cambridge, MRC: Medical Research Council, Nature, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neurodegenerative Research, Neurofibrillary Tangles, Neurofibrillary Tangles (NFTs), Neuropathologic Disorders, Neuropathology, Novel Targets in Neurodegeneration, Paired Helical Filaments (PHFs) and Straight Filaments (SFs), Protein Misfolding, Protofilament Interface in PHFs and SFs, Tau, Tau Aggregation, Tau Filaments, Tau Pathogenesis, Tau Pathology, Tau Protein, Tauopathy, Ultrastructural Polymorphs, United States, US National Institutes of Health, USA
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Another Recent Alzheimer’s Disease Drug Trial Disappointment (Lancet)
Summary Researchers aimed to discover whether LMTM [Leuco-methylthioninium bis(hydromethanesulfonate] might be safe and effective for slowing disease progression in patients with mild to moderate Alzheimer’s Disease. LMTM had previously been found to work as a selective inhibitor of tau protein … Continue reading
Posted in For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Pharmacological Treatments, Quick Insights
Tagged Aberdeen Biomedical Imaging Centre: University of Aberdeen, Abnormal Proteins (Tau), Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog), Alzheimer's Disease Co-operative Study-Activities of Daily Living Inventory (ADCS-ADL) Scale, Alzheimer's Disease Research Unit, BioClinica (Lyon France), Canada, Clinicaltrials No. NCT01689246, CSD Biostatistics (USA), Department of Chemistry: University of Aberdeen, Department of Neurology: University of Southern California, Department of Neurosciences: University of California, Department of Psychiatry and Behavioral Sciences: University of Southern California, Douglas Mental Health University Institute (Montreal), Drug Trials, Drug Trials Failure Rate, European Union Clinical Trials Registry No. 2012-002866-11, France, Institute for Complex Systems and Mathematical Biology: University of Aberdeen, Keck School of Medicine: University of Southern California, Lancet, Leonard Davis School of Gerontology: University of Southern California, Leuco-Methylthioninium (LMTM), Leuco-Methylthioninium Bis(Hydromethanesulfonate): LMTM, McGill Centre for Studies in Aging, Medical Sciences and Nutrition: University of Aberdeen, Methaemoglobinaemia, Methylthioninium Chloride, Mild Alzheimer’s Disease, Misfolded Proteins, Moebius-Consult (Baar Switzerland), Nuffield Department of Clinical Neurosciences: University of Oxford, RadMD (USA), Reasons for Termination of Trials, Salamandra LLC (USA), School of Medicine: University of Aberdeen, School of Medicine: University of California, Switzerland, Tau, Tau Aggregation, Tau Aggregation Inhibitors, Tau Pathology, Tau Protein, Tau Tangles, Tau-Targeting Drugs, TauRx Therapeutics (Aberdeen), United States, University Hospitals and University of Geneva, University of Aberdeen, University of California, University of Oxford, University of Southern California, USA
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Patterns in the Development of Alzheimer’s Disease? (NHS Choices / Science Advances)
Summary Patterns of gene activity (gene expression) in specific areas of the brain may help explain why Alzheimer’s Disease tends to start in certain regions before spreading further through the brain. “ …those regions of the brain in which tissues … Continue reading
Posted in For Doctors (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Quick Insights, UK, Universal Interest
Tagged Abnormal Proteins, Abnormal Proteins (Tau), Aβ Accumulation, Aβ Seeds, Aβ-Plaques, Allen Brain Atlas, Allen Brain Atlas: 3-D Digital Images of Gene Expression, Amyloid and Tau Imaging, Amyloid Beta Protein, Amyloid-β (Aβ), Amyloid-β (Aβ) Accumulation, Behind the Headlines, Braak Staging, Braak Staging of Alzheimer’s Disease, Department of Chemistry: University of Cambridge, Department of Molecular Biosciences: Northwestern University, Histopathological Staging of Alzheimer's Disease, Immune System, Immune System and Neurodegenerative Diseases, Levels of Genes Associated with Inflammation Mapped to Brain Areas, Mapping Brain Areas Affected in Early-Stage Alzheimer's Disease, Mapping Brain Areas Genetically Primed For Protein Overgrowth, Mapping Brain Areas Showing First Signs of Alzheimer's Disease, Mapping Brain Areas Susceptible to Protein Growth Due to Levels of Protein Expression, Mapping Brain Areas Vulnerable to Protein Overgrowth, Mapping Brain Areas: Allen Brain Atlas, Neurofibrillary Tangles, Northwestern University (USA), Pathological Staging, Patterns in the Development of Alzheimer’s Disease, Protein Aggregation, Protein Homeostasis, Protein Misfolding, Protein Overgrowth, Protein Plaques, Protein Seeds (Amyloid), Science Advances, Tau Aggregation, Tau Tangles, Tissue-Specific Progression of Alzheimer's Disease, University of Cambridge, USA, Vulnerability Patterns for Alzheimer's Disease
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Skin Cells: A New Non-Invasive Biomarker? (BBC News / American Academy of Neurology)
Summary Skin may be a good candidate biomarker for detecting hidden brain disorders earlier. Abnormal proteins which accumulate in the brain in neurodegenerative disorders such as Alzheimer’s Disease and Parkinson’s Disease can be found in the skin too. Research is … Continue reading
Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Quick Insights, Universal Interest
Tagged Abnormal Proteins, Abnormal Proteins (Alpha-Synuclein), Abnormal Proteins (Tau), Alzheimer's Disease: Diagnosis, American Academy of Neurology, American Academy of Neurology’s 67th Annual Meeting (Washington 2015), Assessment and Diagnosis, BBC Health News, Biomarkers, Central Hospital at the University of San Luis Potosi, Dementia Diagnosis, Diagnostic Markers, Diagnostic Testing, Differential Diagnosis, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Early Differential Diagnosis, α-Synuclein, α-Synuclein Aggregation, Mexico, National Council of Science and Technology of Mexico, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Non-Invasive Biomarkers, Parkinson’s Disease Diagnosis, Parkinsonism, Post-Mortem Studies, Skin Biopsies, Skin Cells, Skin Tests, Synucleinopathy, Tau, Tau Pathology, Tau Protein, Timely Diagnosis, University of San Luis Potosi (Mexico)
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