Tag Archives: Alzheimer’s Disease

Deep Brain Stimulation for Improving Cognitive Functioning in Alzheimer’s Dementia (Frontiers in Psychiatry)

Summary Deep brain stimulation (DBS) may be able to improve cognitive functioning in Alzheimer’s Disease (AD). This systematic review examines research into DBS and cognitive function in animal and human studies, and reviews the feasibility and efficacy of this type … Continue reading

Posted in Animal Studies, For Doctors (mostly), For Researchers (mostly), International, Management of Condition, Non-Pharmacological Treatments, Quick Insights, Systematic Reviews | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | 1 Comment

Extracellular Tau Proteins Can Spread Tau Pathology (NHS Choices / Journal of Biological Chemistry)

Summary A recent NHS Choices critical appraisal has covered research into the role and development of Tau protein and speculating whether traumatic brain injury might provide opportunities for Tau proteins to spread. This research found that short exposure to Tau … Continue reading

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Recent Systematic Reviews and Meta-Analyses on Pharmacological Treatments

Some of the following articles are available freely, but a suitable Athens password, a journal subscription or one-off payment may be needed for access to the full-text of the other articles. The Bibliographic Citations Irwin, R.W. [and] Brinton, R.D. (2013). … Continue reading

Posted in For Doctors (mostly), For Researchers (mostly), International, Management of Condition, Pharmacological Treatments, Systematic Reviews | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Giant Steps: Re-Tracing the Development of a Promising Research Approach

Summary Following the announcement earlier this week of a probable (if still early-stage) historic breakthrough in finding a potential approach to preventing neurodegeneration across Alzheimer’s, Parkinson’s and Huntington’s Diseases, readers may be interested in viewing the publication history of research … Continue reading

Posted in For Doctors (mostly), For Researchers (mostly), In the News, International, NIHR, Parkinson's Disease, Quick Insights, UK | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Breakthrough Discovery of Chemical to Prevent Neurodegeneration Across Alzheimer’s, Parkinson’s and Huntington’s Diseases (BBC News / NHS Choices / Science Translational Medicine)

Summary A chemical substance has been identified which shows signs of being able to halt a range of neurodegenerative diseases in mice. This may well be a historic event in research, although more research is required; the development of drug treatments … Continue reading

Posted in Animal Studies, BBC News, For Carers (mostly), For Doctors (mostly), For Researchers (mostly), In the News, NHS Digital (Previously NHS Choices), Parkinson's Disease, Quick Insights, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Treatment of Visual Hallucinations in Neurodegenerative Diseases (Future Neurology)

Summary Treatment of visual hallucinations in neurodegenerative disorders is at an early stage of development due to the underlying mechanisms being imperfectly understood. The authors consider various potential approaches to developing treatments, but caution readers that any single treatment is … Continue reading

Posted in Acute Hospitals, Antipsychotics, Community Care, For Carers (mostly), For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), Management of Condition, Mental Health, Models of Dementia Care, NHS, Non-Pharmacological Treatments, Patient Care Pathway, Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Alzheimer’s Disease-Related Gray Matter Atrophy Prevention Using B-Vitamin Treatment (NHS Choices / PNAS)

Summary Researchers explored the prevention of brain atrophy in areas related to cognitive decline and Alzheimer’s disease (AD) by lowering elevated plasma homocysteine using B vitamins. An earlier study on people with increased dementia risk had indicated that high-dose B-vitamin … Continue reading

Posted in For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Nutrition, Pharmacological Treatments, Quick Insights, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Exploring the Potential of Deep Brain Stimulation (TED Talk by Neurosurgeon Andres Lozano)

Summary Neurosurgeon Andres Lozano discusses recent developments in the potential uses of deep brain stimulation (DBS) for the alleviation of symptoms across many different neurological / neuropsychological conditions, including Parkinson’s Disease, dystonia, depression and other mental illnesses, and possibly even … Continue reading

Posted in Depression, International, Mental Health, Non-Pharmacological Treatments, Parkinson's Disease, Quick Insights, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Structure of Neurodegenerative Disease Molecule Mapped (NHS Choices / Nature / Mancunian Matters)

Summary Researchers from the University of Manchester, the University of Leicester and institutions in Portugal, France and Germany have performed early-stage research into the structure of an enzyme (Kynurenine 3-Monooxygenase, or KMO) which has been implicated in the development of … Continue reading

Posted in Animal Studies, For Doctors (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, UK, Universal Interest | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Neuroimaging for Early Diagnosis of Neurodegenerative Disease

Summary The roles of magnetic resonance and radionuclide imaging in the early diagnosis and pre-clinical detection of dementia and parkinsonism are reviewed. Structural imaging has traditionally been used to exclude alternate diagnoses, but recent advances in magnetic resonance and multimodal … Continue reading

Posted in Diagnosis, For Doctors (mostly), For Researchers (mostly), Parkinson's Disease | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | Leave a comment