Tag Archives: Alzheimer’s Disease: Diagnosis

Blood Test Able to Predict Alzheimer’s Disease Decades Before Symptoms? (BBC News / Neurology)

Posted on August 3, 2019 by Dementia and Elderly Care News

Summary Research published in the Neurology journal claims a significant breakthrough in the development of a blood test (for plasma Aβ42/Aβ40) which may be able to predict Alzheimer’s Disease onset with 94% accuracy. Due caution: “But it’s important to note … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Quick Insights, Universal Interest | Tagged Alzheimer's Disease: Diagnosis, Alzheimer’s Early Screening, Amyloid, Amyloid and Tau PET, Amyloid Beta, Amyloid Beta (Aβ42 and Aβ40), Amyloid Beta Protein, Amyloid-β (Aβ), Amyloid-β Protein, BBC Health News, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Blood Proteins as Biomarkers of Disease Research, Blood Test for Brain Amyloidosis: Validated Using Amyloid PET and CSF p-tau181/Aβ42 as Reference Standards, Blood Tests, Blood-Based Biomarkers, Blood-Based Biomarkers of Pre-Symptomatic Alzheimer’s Disease, Brain Imaging, Brain Research, Case Finding, Conversion to Dementia From Prodromal Disease, Dementia Diagnosis, Dementia Innovation, Dementia Research, Dementia Screening, Department of Neurology: Washington University, Diagnosis, Diagnosis of Alzheimer's Disease, Diagnostic Imaging, Division of Biostatistics: Washington University, Drug Development for Alzheimer's Disease, Early Detection of Preclinical Disease, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Hope Center for Neurological Disorders: Washington University, Knight Alzheimer's Disease Research Center: Washington University, Mallinckrodt Institute of Radiology: Washington University, Neurology (Journal), Non-Invasive Biomarkers, Plasma Biomarkers, Plasma β-Amyloid 42/40, Plasma Protein Markers of MRI Measures in Asymptomatic Individuals, Preclinical Alzheimer's Disease, Preclinical Biomarkers in Alzheimer's Disease, Predictive Ability (of Tests), Prodromal Alzheimer's Disease, Protein-Based Biomarkers in Blood May Deliver Accurate Diagnoses, Rapid Screening, Recruitment Onto Dementia Clinical Trials, SAP (Protein), SAP: Serum Amyloid Protein, Screening, Screening for Dementia, Washington University School of Medicine | Leave a comment

Dementia Biomarkers Re-Explored? (General Psychiatry / JGCR)

Posted on June 17, 2019 by Dementia and Elderly Care News

Summary A recent systematic review examines biomarkers, as strictly defined, for neurodegenerative diseases. “Vast improvements in neuroimaging techniques have led to newly discovered biomarkers and diagnostics”. p.5 Behavioural biomarkers are mentioned hardly at all. Full Text Link Reference Maclin, JMA. … Continue reading →

Posted in Alzheimer’s Research UK, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Mental Health, Personalisation, Quick Insights, Systematic Reviews, UK, Universal Interest | Tagged 18F-florbetaben, 18F-flutemetamol, 18Fflorbetapir, Alzheimer's Disease: Diagnosis, Alzheimer’s Disease, Alzheimer’s Disease and Dementia, Alzheimer’s Disease Biomarkers, Alzheimer’s Research UK (ARUK), Amyloid and Tau PET, APOE e4 (Apolipoprotein E e4), Apolipoprotein E (APOE) e4 Allele, Behavioural Biomarkers, Beta-Amyloid PET Imaging, Biomarker Development, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Canonical Syndromes of Primary Progressive Aphasia: Non-Fluent / Agrammatic Variant (nfvPPA), Canonical Syndromes of Primary Progressive Aphasia: Semantic Variant (svPPA), Carbon-11 Pittsburgh Compound-B (C-PIB) Radioisotope Tracer, Cerebral Metabolic Rate for Glucose (CMRgl), Cerebrospinal Fluid (CSF) Biomarkers, Cerebrospinal Fluid and Serum MHPG, CMRgl Decline, Corticobasal Degeneration (CBD), CSF 3-methoxy-4-hydrox-yphenylglycol (MHPG), Dementia With Lewy Bodies (DLB), Differential Diagnosis, DLB: Dementia with Lewy Bodies, Docosahexaenoic Acid (DHA), Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Eicosapentaenoic Acid (EPA), Frontotemporal Dementia (FTD), α-Synuclein, Journal of Geriatric Care and Research (JGCR), Lewy Body Dementia (LBD), Magnetic Resonance Imaging (MRI), Medial Temporal Lobe Atrophy (MTA), Medial Temporal Lobes (MTL), Metabolic Syndrome (MetS), MRI Brain Imaging, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuroimaging, Neuroimaging in Dementia Diagnosis, Non-Invasive Biomarkers, Pick’s Disease (Frontotemporal Dementia), Positron Emission Tomography (PET), Preclinical Alzheimer's Disease, Primary Progressive Aphasia (PPA), Progressive Supranuclear Palsy (PSP), Rapid Screening, Screening for Dementia, Sea Hero Quest (SHQ) Game, Sea Hero Quest VR, Tau PET, Timely Diagnosis, VaD: Vascular Dementia, Variants of Primary Progressive Aphasia (PPA), Vascular Dementia, [18F]THK5351 | Leave a comment

Functional Memory Disorders: a Potential Reason for Dementia Misdiagnoses? (BJGP)

Posted on May 8, 2019 by Dementia and Elderly Care News

Summary The authors of this review speculate whether a proportion of persons receiving referrals to memory clinics may not have dementia (or perhaps not even pre-clinical neurodegenerative disease at all); this category of patients may instead have functional disorders of … Continue reading →

Posted in Community Care, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), NHS, Quick Insights, UK, Universal Interest | Tagged Ability to Answer Multi-Part Questions, Accounts and Metaphor, Alzheimer Phobia (Speculative Construct), Alzheimer's Disease: Diagnosis, Anosognosia, Assessment and Diagnosis, Assessment of Cognition During Natural Interaction, Attending Alone, Autobiographical Information, Awareness of Repetition, BJGP: British Journal of General Practice, British Journal of General Practice, Cognitive Assessments to Help Differentiate Between Dementia and Functional Disorders of Memory, Cognitive Decline and Dementia, Companion Involvement, Compensatory Strategies: Humour, Competent Identity, Conversation Analysis, Conversation Analysis in Differential Diagnosis of Memory Problems, Conversation Analytic (CA) Interventions, Conversational Assessment in Memory Clinic Encounters, Dementia Diagnosis, Dementia-Related Misdiagnosis, Depressive Pseudo-Dementia, Differential Diagnosis, Differential Diagnosis of Memory Problems, Dominant Humour, Early Differential Diagnosis, East London Foundation Trust, Face-Saving Behaviour, Features of Communication to Discriminate Between Neurodegenerative and Functional Memory Disorders, Forgetful Identity, Functional Memory Disorder (FMD), General Practitioner Assessment of Cognition, Head Turning Sign (HTS), Homerton Psychological Medicine (East London), I Don’t Know (IDK) Responses, Knowledge Reinforcing Tokens, Medically Unexplained Symptoms (MUS), Memory Clinics, Mild Cognitive Impairment (MCI), Neuropsychiatry Service: St George's Hospital (London), Patient Ability to Answer and Participate in Consultation, Prodromal Dementia, Quick Relevant Detailed and Unsolicited accounts of Memory Problems, Referral to Memory Clinics: Assessment, Requesting Companion Confirmation, Sheffield Institute for Translational Neuroscience (SITraN): University of Sheffield, South West London and St George’s Mental Health NHS Trust, St George's Hospital (London), Subjective Cognitive Complaints, University of Sheffield, Working Memory Within the Interaction (Refering to Things Said Earlier) | Leave a comment

Eye Tests for Early Detection of Alzheimer’s Disease? (NHS Digital / Ophthalmology Retina)

Posted on March 20, 2019 by Dementia and Elderly Care News

Summary Further discussion about the possibilities of using inexpensive eye tests to detect Alzheimer’s Disease, perhaps years before symptoms appear. This particular technique involves the examination of blood vessels and blood flow in the retina, as detected by Octa (Optical … Continue reading →

Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, NHS Digital (Previously NHS Choices), Quick Insights, Universal Interest | Tagged Alzheimer's Disease: Diagnosis, Alzheimer’s Disease, Alzheimer’s Disease and Dementia, Alzheimer’s Disease Biomarkers, Assessment and Diagnosis, Bazian, Behind the Headlines, Biomarkers, Biomarkers Predicting Cognitive Decline and Alzheimer's Disease, Central Subfield Thickness (CST), Cognitive Impairment, Critical Appraisals, Dementia Case Finding, Dementia Diagnosis, Dementia Screening, Diagnosis, Diagnosis of Alzheimer's Disease, Diagnostics, Duke University in North Carolina, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Early Treatment Diabetic Retinopathy Study, Eye Examinations, Foveal Avascular Zone (FAZ) Area, Karen L. Wrenn Alzheimer's Disease Award, Macular Ganglion Cell-Inner Plexiform Layer (GC-IPL), MCI: Mild Cognitive Impairment, Mild Cognitive Impairment, National Institutes of Health, National Institutes of Health (NIH), National Institutes of Health (US), Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, NHS Digital (Formerly NHS Choices), Non-Invasive Biomarkers, Octa: Optical Coherence Tomography Angiography, Ophthalmology Retina, Optical Coherence Tomography, Optical Coherence Tomography Angiography (OCTA), Preclinical Alzheimer's Disease, Rapid Screening, Research to Prevent Blindness Inc. (New York), Retina as Early Biomarker of Neurodegeneration, Retinal Biomarkers, Retinal Examination in Neurodegenerative Diseases, Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease, Retinal Microvascular and Neurodegenerative Changes in Mild Cognitive Impairment, Retinal Vessel Density (VD), Screening, Screening for Dementia, Timely Diagnosis, US National Institutes of Health (NIH), USA | Leave a comment

Limited Usefulness of MRI for Improving the Prediction of Dementia? (BMJ)

Posted on July 20, 2015 by Dementia and Elderly Care News

Summary Research indicates that MRI does not significantly improve the prediction of dementia. It does have some value in differential diagnosis. Full Text Link Reference Stephan, BC. Tzourio, C. [and] Auriacombe, S. [et al] (2015). Usefulness of data from magnetic … Continue reading →

Posted in Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), International, Quick Insights, UK | Tagged Alzheimer's Disease: Diagnosis, Assessment and Diagnosis, BMJ, Bordeaux University Hospital, Brain Imaging, Brain Volume, British Medical Journal (BMJ), Cerebral Brain Volume, Dementia Diagnosis, Dementia Screening, Diagnosis of Dementia, Differential Diagnosis, Dijon Magnetic Resonance Imaging Study Cohort, Early Diagnosis, Early Screening, France, France University of Bordeaux, French Three-City Study, Grey-Matter Volume, Hippocampal Volume, Imaging, Inserm Research Centre for Epidemiology and Biostatistics (U897), Inserm: Team Epidemiology and Neuropsychology of Brain Aging, Inserm: Team Neuroepidemiology, Institute of Health and Society: Newcastle University, MRI Brain Imaging, Neuroimaging, Neuroimaging in Dementia Diagnosis, Neuroimaging of Dementia, Neuroimaging Tools, Newcastle University, Screening for Dementia, Team Neuroepidemiology (Inserm), Three-City Study, Timely Diagnosis, White Matter Lesion (WML) | Leave a comment

Skin Cells: A New Non-Invasive Biomarker? (BBC News / American Academy of Neurology)

Posted on March 2, 2015 by Dementia and Elderly Care News

Summary Skin may be a good candidate biomarker for detecting hidden brain disorders earlier. Abnormal proteins which accumulate in the brain in neurodegenerative disorders such as Alzheimer’s Disease and Parkinson’s Disease can be found in the skin too. Research is … Continue reading →

Posted in BBC News, Diagnosis, For Doctors (mostly), For Nurses and Therapists (mostly), For Researchers (mostly), In the News, International, Parkinson's Disease, Quick Insights, Universal Interest | Tagged Abnormal Proteins, Abnormal Proteins (Alpha-Synuclein), Abnormal Proteins (Tau), Alzheimer's Disease: Diagnosis, American Academy of Neurology, American Academy of Neurology’s 67th Annual Meeting (Washington 2015), Assessment and Diagnosis, BBC Health News, Biomarkers, Central Hospital at the University of San Luis Potosi, Dementia Diagnosis, Diagnostic Markers, Diagnostic Testing, Differential Diagnosis, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Early Differential Diagnosis, α-Synuclein, α-Synuclein Aggregation, Mexico, National Council of Science and Technology of Mexico, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Non-Invasive Biomarkers, Parkinson’s Disease Diagnosis, Parkinsonism, Post-Mortem Studies, Skin Biopsies, Skin Cells, Skin Tests, Synucleinopathy, Tau, Tau Pathology, Tau Protein, Timely Diagnosis, University of San Luis Potosi (Mexico) | Leave a comment

Dementia Diagnosis and Prediction Using Eye Examinations? (BBC News)

Posted on October 27, 2014 by Dementia and Elderly Care News

Summary A £1.1m three year study involving researchers from Dundee University and Edinburgh will investigate whether eye tests can aid non-invasive diagnosis by providing an “early warning” of Alzheimer’s Disease and other conditions. It is thought that changes in the eye … Continue reading →

Posted in BBC News, Diagnosis, For Researchers (mostly), In the News, Quick Insights, Scotland, UK, Universal Interest | Tagged Alzheimer's Disease: Diagnosis, Assessment and Diagnosis, BBC Health News, BBC Tayside and Central Scotland, Dementia Diagnosis, Diagnostic Markers, Diagnostic Testing, Differential Diagnosis, Drusen (Spots on Retina), Dundee, Early Diagnosis, Early Diagnosis of Alzheimer's Disease, Edinburgh, Engineering and Physical Sciences Research Council (EPSRC), EPSRC: Engineering and Physical Sciences Research Council, Eye Cells, Eye Examinations, Neurodegeneration, Neurodegenerative Disease Research, Neurodegenerative Diseases, Neuronal Loss, Ninewells Hospital, Non-Invasive Biomarkers, Optomap Screening Test, Optos (Retinal Imaging Company), Retinal Ganglion Cell Layer, Retinal Inner Nuclear Layer, Retinal Neuronal Loss, Timely Diagnosis, University of Dundee | Leave a comment

Tag Archives: Alzheimer’s Disease: Diagnosis

Blood Test Able to Predict Alzheimer’s Disease Decades Before Symptoms? (BBC News / Neurology)

Dementia Biomarkers Re-Explored? (General Psychiatry / JGCR)

Eye Tests for Early Detection of Alzheimer’s Disease? (NHS Digital / Ophthalmology Retina)

Limited Usefulness of MRI for Improving the Prediction of Dementia? (BMJ)

Skin Cells: A New Non-Invasive Biomarker? (BBC News / American Academy of Neurology)

Dementia Diagnosis and Prediction Using Eye Examinations? (BBC News)

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